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Second- and Third-Line Salvage Chemotherapy Followed by Allogeneic Stem Cell Transplantation Leads to High Survival Rates in Primary Refractory AML—A Population-Based Study

Refractory acute myeloblastic leukemia (AML) is poorly studied. In this study, we characterized primary refractory AML and investigated treatment and outcome in a population-based setting. Based on all AML patients receiving intensive induction therapy at 12 Swedish hospitals from 2011 to 2018 (N = 1221), we identified 306 patients that failed to achieve composite complete remission (CRc) after fi

Validation of Guidelines for Genetic Investigation of Myeloid Neoplasms with Germline Predisposition : Results from a Prospective Cohort Study

Purpose: In a multicenter prospective cohort study, we assessed the diagnostic yield of the Nordic guidelines for germline investigation in myeloid neoplasms and mapped the spectrum of inherited and somatic variants. Experimental Design: Eighty-five patients (acute myeloid leukemia, n = 38; myelodysplastic syndromes, n = 26; thrombocytopenia, n = 14; and other, n = 7) fulfilling the Nordic criteri

Overcoming Energy Transfer for the Metallophotoredox Catalyzed Decarboxylative Alkenylation between Alkylcarboxylic Acids and Enol Triflates

Abstract Herein we report on the decarboxylative alkenylation between alkyl carboxylic acids and enol triflates. The reaction is mediated by a dual catalytic nickel and iridium system, operating under visible light irradiation. Two competing catalytic pathways, from the excited state iridium photocatalyst, are identified. One is energy transfer from the excited state, resulting in formation of an

Phase field crystal modeling of grain boundary migration : Mobility, energy and structural variability

Phase field crystal (PFC) modeling is employed to investigate the migration dynamics of FCC and BCC symmetric tilt grain boundaries (GBs) under an applied artificial driving pressure. The evolution of GB position, velocity, mobility, structure and energy is tracked to explore the interdependencies of these quantities. The use of PFC permits simulations with atom scale spatial resolution over exten

Erythrina Alkaloid Analogues as nAChR Antagonists-A Flexible Platform for Leads in Drug Discovery

Erythrina alkaloids and their central nervous system effects have been studied for over a century, mainly due to their potent antagonistic actions at β2-containing nicotinic acetylcholine receptors (nAChRs). In the present work, we report a synthetic approach giving access to a diverse set of Erythrina natural product analogues and present the enantioselective total synthesis of (+)-Cocculine and

Synthesis of Siphonazole B Through Domino Cycloisomerization-Oxazolonium Ion Rearrangements

Abstract 4-Alkenyl- and 4-acyloxazoles represent important substructures across a diverse array of bioactive molecules. Practical methods to synthesize these motifs are, therefore, of considerable interest. Here, we develop a novel domino process wherein a cycloisomerization is followed by a 1,2-rearrangement via an oxazolonium ion to yield 4-alkenyloxazoles from an abundant β-chloro-N-benzyl prop4-Alkenyl- and 4-acyloxazoles represent important substructures across a diverse array of bioactive molecules. Practical methods to synthesize these motifs are, therefore, of considerable interest. Here, we develop a novel domino process wherein a cycloisomerization is followed by a 1,2-rearrangement via an oxazolonium ion to yield 4-alkenyloxazoles from an abundant β-chloro-N-benzyl propargylamin

Development of a Divergent Route to Erythrina Alkaloids

Erythrina alkaloids were identified at the end of the 19th century and today, more than 100 members of the erythrinane family have been isolated. They are characterized by a unique tetracyclic, α-tertiary spiroamine scaffold. Herein we detail our efforts towards the development of a divergent enantioselective synthesis of (+)-dihydro-β-erythroidine (DHβE) - one of the most prominent members of thi

Linking daylighting practice and education : a focus group-based study on motivations driving practitioners

This article describes practitioners’ motivations to work with daylighting and their educational needs, explored through the Goal Framing Theory (GFT) lens. The study is based on the results of 14 focus groups with 64 daylight experts from Denmark, Italy, Poland, and Sweden. The results, analysed through the GFT, revealed that experts’ motivations were driven by normative, hedonic, and gain goals

Health promotion in elite Para sport : bridging knowledge gaps and addressing individual needs-a qualitative evaluation of the Safe and Healthy Para sport (SHAPE) intervention

OBJECTIVE: To qualitatively explore the perceptions of Para athletes, coaches and stakeholders of the implementation, use and effects of the health promotion intervention 'Safe and Healthy Para sport' (SHAPE). A secondary aim was to explore participants' perceptions of how safety and health in Para sport could be further developed.METHODS: As part of a process evaluation, this qualitative, descrip

Structures and Dynamics of Low-income Work in Sweden : A Geographical Inquiry

Framväxten och övergången till en alltmer kunskapsbaserad ekonomi har de senaste decennierna omformat grunderna för arbete, möjligheter och politiska attityder i de flesta avancerade ekonomier. Mycket av den offentliga och akademiska debatten har i detta sammanhang betonat ökande regionala klyftor, växande ojämlikheter, ökad osäkerhet, minskad social rörlighet och i kölvattnet av detta också ett vThe transformation to the knowledge economy has reshaped the foundations of work, opportunity, and political sentiment across advanced democracies. Much of the public and academic debate has emphasized deepening regional divides, increasing inequalities, growing precarity, the erosion of upward mobility, and growing social discontent.This PhD thesis explores the geographies of low-income work in S

Scholar-activism as an object of study in a diverse literature: preconditions, forms, and implications

Scholar-activism—academic scholars engaging in some form of activism—has recently become a prominent phenomenon as we witness calls for scholars to engage in political, social, and environmental causes that go beyond their traditional academic duties. An emerging literature focuses on scholar-activism as an object of study. However, the literature is scattered across rather disconnected discipline

Parenting in screen times : Negotiations, practices and experiences in everyday family life

Avhandlingen handlar om samtida föräldraskap och skärmtid. Skärmtid används ofta i vardagligt språkbruk för att beteckna aktiviteter på och kring skärmteknologier, men det har även blivit ett fenomen som ofta beskrivs i termer av konfrontation, osäkerhet och frustration i hemmet (Livingstone & Blum-Ross 2020; Sandberg et al. 2024a). Föräldrar förväntas hantera och kontrollera deras barns skärmThe dissertation is about modern-day parenting in relation to what is commonlyknown as screen time. While screen time in everyday language is used to connoteactivities on screen technologies, it has become a phenomenon which oftendescribes a site of struggle, uncertainty and frustration in the domestic space(Livingstone & Blum-Ross 2020; Sandberg et al. 2024a). Parents are expected tomanage an

4D-ONIX for reconstructing 3D movies from sparse X-ray projections via deep learning

The X-ray flux from X-ray free-electron lasers and storage rings enables new spatiotemporal opportunities for studying in-situ and operando dynamics, even with single pulses. X-ray multi-projection imaging is a technique that provides volumetric information using single pulses while avoiding the centrifugal forces induced by conventional time-resolved 3D methods like time-resolved tomography, and

Confined and unconfined articular cartilage mechanics : Effect of creep duration on estimations of mechanical properties

Recent findings suggest that cartilage mechanical function may be a biomarker for early osteoarthritis (OA) pathology. Thus, the development of methodologies for in-vivo applications has expanded. However, when creep tests are performed, inconsistency in applied stress and testing duration impede meaningful comparisons. Therefore, this study investigates the impact of creep duration on cartilage m

A real effort vs. standard public goods experiment : Asking for effort does make a difference

This paper reports results from an exploratory experimental study (N = 181) comparing an effort based public good game to a standard public good game — each presented in a gain and a loss frame. The data show lower average contributions and more free-riders in the effort treatments, with the most notable effect showing for men in the loss frame (comparing standard vs. effort, contributions drop fr

Sociodemographic and clinical characteristics of 1,234 individuals diagnosed with trichotillomania in the Swedish National Patient Register

Trichotillomania is an understudied, underrecognized, and difficult-to-treat psychiatric disorder that affects about 1–2% of the population, predominantly women. This study aimed to characterize the sociodemographic and clinical characteristics of a Swedish cohort of individuals with a diagnosis of trichotillomania assigned in specialist services across the country. Through the Swedish National Pa