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Negative-Ion/Positive-Ion Coincidence Yields of Core-Excited Water

We report yields of mass-resolved negative ions and positive ions measured in coincidence after core-excitation of water molecules. The analysis of negative-ion/positive-ion and negative-ion/positive-ion/positive-ion coincidence events provides new information on pathways leading to negative ion production, enhancing the present understanding of the dissociation processes of the water molecule. Di

Brood size constrains the development of endothermy in blue tits

Altricial birds are unable to maintain body temperature when exposed to low ambient temperatures during the first days after hatching. Thermoregulatory capacity begins to form as postnatal development progresses, and eventually nestlings become homeothermic. Several factors may influence this development at both the level of the individual and the level of the whole brood, but to our knowledge no

Calculation of Borehole Thermal Resistance

The borehole thermal resistance – that is, the thermal resistance between the fluid in the U-tube and the borehole wall – is a key performance characteristic of a closed-loop borehole ground heat exchanger. Lower borehole thermal resistance leads to better system performance. Since the original identification of the concept borehole thermal resistance by Mogensen (1983), there have been numerous m

Transferring Ownership of Public Housing to Existing Tenants : A Market Design Approach

This paper explores a housing market with an existing tenant in each house and where the existing tenants initially rent their houses. The idea is to identify equilibrium prices for the housing market given the prerequisite that a tenant can buy any house on the housing market, including the one that he is currently possessing, or continue renting the house he is currently occupying. The main cont

Outcome after percutaneous coronary intervention for different indications : Long-term results from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR)

Aims: The aim of this study was to evaluate clinical outcome for different indications for PCI in an unselected, nationwide PCI population at short-and long-term follow-up. Methods and results: We evaluated clinical outcome up to six years after PCI in all patients undergoing a PCI procedure for different indications in Sweden between 2006 and 2010. A total of 70,479 patients were treated for stab

Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalised Nutrition : Part 1 - Fields of Precision Nutrition

Diversity in the genetic profile between individuals and specific ethnic groups affects nutrient requirements, metabolism and response to nutritional and dietary interventions. Indeed, individuals respond differently to lifestyle interventions (diet, physical activity, smoking, etc.). The sequencing of the human genome and subsequent increased knowledge regarding human genetic variation is contrib

Rosuvastatin treatment affects both basal and glucose-induced insulin secretion in INS-1 832/13 cells

Rosuvastatin is a member of the statin family. Like the other statins it is prescribed to lower cholesterol levels and thereby reduce the risk of cardiovascular events. Rosuvastatin lowers the cholesterol levels by inhibiting the key enzyme 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase) in the cholesterol producing mevalonate pathway. It has been recognized that apart from their ben

Carpal tunnel syndrome treated with guided brain plasticity : a randomised, controlled study

Introduction: Guided plasticity, induced by cutaneous forearm anaesthesia, improves hand sensibility in patients with nerve injury and vibration-induced neuropathy. This study investigated whether patients with carpal tunnel syndrome (CTS) would benefit from cutaneous forearm anaesthesia. Methods: Seventy patients with clinical and electroneurography-verified CTS were randomised to sensory trainin

Breast density assessment using breast tomosynthesis images

In this work we evaluate an approach for breast density assessment of digital breast tomosynthesis (DBT) data using the central projection image. A total of 348 random cases (both FFDM CC and MLO views and DBT MLO views) were collected using a Siemens Mammomat Inspiration tomosynthesis unit at Unilabs, Malmö. The cases underwent both BI-RADS 5th Edition labeling by radiologists and automated volum

The characteristics of malignant breast tumors imaged using a prototype mechanical imaging system as an adjunct to mammography

Breast cancer is diagnosed by a combination of modalities. Measuring the elasto-mechanical properties of suspicious lesions, by e.g. ultrasound elastography, can help differentiate malignant from benign findings. Using a prototype Mechanical Imaging (MI) system as an adjunct to mammography, the aim of this study was to characterize tumors using MI and compare the readings to those from the contral

QM/MM Calculations on Proteins

In this chapter, I discuss combined quantum mechanics (QM) and molecular mechanics (MM; QM/MM) calculations for proteins. In QM/MM, a small but interesting part of the protein is treated by accurate QM methods, whereas the remainder is treated by faster MM methods. The prime problems with QM/MM calculations are bonds between the QM and MM systems, the selection of the QM system, and the local-mini

GCKR : How genetic variation across the allelic spectrum influences protein function and metabolic traits in humans

Genome-wide association studies (GWAS) have generated considerable interest in glucokinase regulatory protein (GKRP; gene name GCKR) which is an inhibitor of hepatic glucokinase (GCK), an enzyme that plays a critical role in glucose update and disposal in liver. From the initial discovery of GCKR variants associated with triglyceride and glucose levels through the identification of pleiotropic ass

Demonstration of a WNT5A-IL-6 positive feedback loop in melanoma cells : Dual interference of this loop more effectively impairs melanoma cell invasion

Increased expression and signalling of WNT5A and interleukin-6 (IL-6) have both been shown to promote melanoma progression. Here, we investigated the proposed existence of a WNT5A-IL-6 positive feedback loop that drives melanoma migration and invasion. First, the HOPP algorithm revealed that the invasive phenotype of cultured melanoma cells was significantly correlated with increased expression of

The outcome of lumbar disc herniation surgery is worse in old adults than in young adults : A study of 14,090 individuals in the Swedish Spine Surgery Register (SweSpine)

Background and purpose — The outcome of surgical treatment of lumbar disc herniation (LDH) has been thoroughly evaluated in middle-aged patients, but less so in elderly patients. Patients and methods — With validated patient-reported outcome measures (PROMs) and using SweSpine (the national Swedish Spine Surgery Register), we analyzed the preoperative clinical status of LDH patients and the 1-year

Dynamic isotropy in 3-DOF Gantry Tau robots - An analytical study

3-DOF Gantry Tau is a type of parallel robot, consisting of six struts configured in three clusters, which provides three translational DOFs. It has increasing industrial use in applications where large workspace and high stiffness are required. In fact, the concept of dynamic isotropy, where all the natural frequencies of a system are equal, can be employed in order to effectively optimize the ge

Kinesiophobia and its relation to pain characteristics and cognitive affective variables in older adults with chronic pain

Background: The contribution of kinesiophobia (fear of movement) to the pain experience among older adults has been poorly evaluated. The aim of this study was to study prevalence at baseline, development over a 12-month period and cognitive-affective variables of kinesiophobia in a population-based sample of older adults with chronic pain. Methods: The study included 433 older adults (+65 years)

Fall-related activity avoidance in relation to a history of falls or near falls, fear of falling and disease severity in people with Parkinson's disease

Background: There is limited knowledge concerning fall-related activity avoidance in people with Parkinson's disease (PD); such knowledge would be of importance for the development of more efficient PD-care and rehabilitation. This study aimed to examine how fall-related activity avoidance relates to a history of self-reported falls/near falls and fear of falling (FOF) as well as to disease severi

Possessive predicational vocatives in Scandinavian

Scandinavian is known to have vocative phrases that contain a possessive second person pronoun and a noun, and possibly also one or more adjectives, as in the Norwegian example din lille fjott, which means ‘you little dork’ although din is formally identical to the possessive pronoun for second person singular. In this paper, I will show that possessive predicational vocatives, as I call them, inv

Kolkata Paise Restaurant Problem and the Cyclically Fair Norm

In this paper we revisit the Kolkata Paise Restaurant problem by allowing for a more general (but common) preference of the n customers defined over the set of n restaurants. This generalization allows for the possibility that each pure strategy Nash equilibrium differs from the Pareto efficient allocation. By assuming that n is small and by allowing for mutual interaction across all customers we