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Midkine - a host defence protein

Popular Abstract in Swedish Vi utsätts varje dag för en stor mängd bakterier som skulle kunna göra oss sjuka, men för det mesta håller vi oss ändå friska. Epitelcellerna på hudens yta och på lungornas slemhinna bildar det första försvaret mot sjukdomsframkallande bakterier, dels genom att de utgör en fysisk barriär men också genom att de kan producera små bakteriedödande substanser, så kallade antEvery day we encounter many potentially harmful microbes in our environment. The epithelial linings constitute an anatomical barrier protecting us and they also produce antimicrobial polypeptides (AMPs) that act as a chemical barrier. These AMPs are small and positively charged, killing a broad range of microbes rapidly. They can either be constitutively produced or rapidly induced when epithelial

Viruses as supramolecular self-assemblies: modelling of capsid formation and genome packaging

Viruses are considered the simplest form of live. A virus is basically composed of genomic material surrounded by a protecting capsid. Today, full molecular details of many viruses are known, and several subclasses can be discerned. In this review, we present recent advances made over the past few years obtained from theoretical considerations and model simulations to improve our understanding on

Surface site coordination dependent responses resolved in free clusters: applications for neutral sub-nanometer cluster studies

In this paper we demonstrate how surface site specific experimental information can be obtained from free low nanometer scale clusters using photoelectron spectroscopy utilising synchrotron radiation. In addition, we show how it can be used to gain insight into the geometry and surface structure of the clusters. The present experiments were conducted on alkali metal halides, RbCl and CsCl, which w

Current smoking status is a strong predictor of radiographic progression in early rheumatoid arthritis: results from the SWEFOT trial

Objectives To study clinical predictors for radiographic progression after 1 year in an early rheumatoid arthritis (RA) trial. Methods In the SWEFOT trial population, disease modifying antirheumatic drug (DMARD) naive RA patients started methotrexate; 3-month responders (DAS28 = 5 increase after 1 year. Potential baseline predictors of radiographic progression were tested using multivariable logis

Can we always trust rhinomanometry?

Objectives: Rhinomanometry before and after decongestion distinguishes a nasal airway organic stenosis from congestion of nasal mucosa in patients with nasal stuffiness. Together with rhinoscopy and patient history, it is used to decide if nasal surgery would benefit the patient. Rhinomanometry measurements should thus be reliable and reproducible. Materials and methods: We performed repetitive ac

Eating problems and overlap with ADHD and autism spectrum disorders in a nationwide twin study of 9- and 12-year-old children.

Aim. To establish the prevalence of restrictive eating problems, the overlap and association with attention-deficit/hyperactivity disorder (ADHD), and autism spectrum disorders (ASD) and to estimate the heritability of eating problems in a general population sample of twins aged 9 and 12. Methods. Parents of all Swedish 9- and 12-year-old twin pairs born between 1993 and 1998 (n = 12,366) were int

Search for direct pair production of a chargino and a neutralino decaying to the 125 GeV Higgs boson in [Formula: see text] TeV [Formula: see text] collisions with the ATLAS detector.

A search is presented for the direct pair production of a chargino and a neutralino [Formula: see text], where the chargino decays to the lightest neutralino and the [Formula: see text] boson, [Formula: see text], while the neutralino decays to the lightest neutralino and the 125 GeV Higgs boson, [Formula: see text]. The final states considered for the search have large missing transverse momentum

Understanding the ERP system use in budgeting

This paper investigates the enterprise resource planning (ERP) system use in budgeting in order to explain how and why ERP system are used or not used in budgeting practices. Budgeting is considered as a social phenomenon which requires flexibility for decision-making and integration for management controls. The analysis at the activity levels, guided by the concept of ‘conflict’ in structuration

Islands kristnande - en kritisk undersökning

In all works on medieval Iceland, we meet the same narrative of the conversion of Iceland to Christianity, which is supposed to have taken place in the year 999 or 1000 AD. But how does this narrative stand the trial of source criticism? Radical source criticism was introduced in Nordic historiography when Lauritz Weibull published his Critical Studies in Nordic History Around the Year 1000 in 191

Classical enterotoxins of coagulase-positive Staphylococcus aureus isolates from raw milk and products for raw milk cheese production in Ireland

Toxin-producing Staphylococcus aureus can be present in raw milk and therefore in cheese made from raw milk. To determine the number and type of toxin producers in raw milk used for raw milk cheese production in Ireland, 117 samples of raw milk and related products from five raw milk suppliers, to four raw milk cheesemakers in the South of Ireland, were analysed for coagulase positive S. aureus. E