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Lower disease activity and disability in Swedish patients with rheumatoid arthritis in 1995 compared with 1978
The aim of this study was to evaluate differences in disease activity, disability, and medical treatment in consecutive patients with rheumatoid arthritis seen at the outpatient clinics in Malmö, in 1978 (n=148) and 1995 (n=164). The groups were similar with regard to age, gender, disease duration, and the proportion having had hip or knee replacement surgery. The patients in 1995 had lower values
Noncollagenous Proteins: Glycoproteins and Related Proteins
IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation.
Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis
Genetic control of arthritis in rats
Diagnosis of osteoarthritis in relation to molecular processes in cartilage: comment on the article by Clark et al.
Molecular markers for assessment of cartilage damage in rheumatoid arthritis
Up-regulation of cartilage oligomeric matrix protein at the onset of articular cartilage degeneration in a transgenic mouse model of osteoarthritis
Circulating collagen metabolites in systemic sclerosis. Differences between limited and diffuse form and relations to pulmonary involvement
Matrix Glycoproteins and Proteoglycans in Cartilage
Nya läkemedel mot reumatoid artrit : Förbättrade behandlingsmöjligheter ställer nya krav på sjukvårdsorganisationen
Cytokines, metalloproteinase, their inhibitors, and COMP: relation to radiological progression and inflammation in early rheumatoid arthritis
Behandling med TNF-hämmare vid reumatoid artrit
Markers of joint tissue turnover in osteoarthritis
Human antibody reactivity against the lower matrix protein (pp65) produced by cytomegalovirus
The lower matrix protein (pp65) is a major product of many laboratory strains of cytomegalovirus (CMV). It is thus an integral part of many CMV serological assays based on native antigen. Recombinant fragments of pp65 have previously been investigated for their usefulness in more-defined assays. The latter antigens have, however, failed to develop a positive response with serum samples derived fro
Generation of diversity in a human anti-viral response
Enhanced ELISA sensitivity using TCA for efficient coating of biologically active lipopolysaccharides or lipid A to the solid phase
A new simple, reproducible and sensitive ELISA that uses trichloroacetic acid (TCA) for the coating of lipooligosaccharide (LOS), smooth lipopolysaccharide (LPS) or lipid A to the solid phase has been developed. The experimental parameters (temperature of coating, time of coating, antigen concentration and TCA concentration) were evaluated by a complete factorial design (24). As a result of the ev
Site-directed primary in vitro immunization : Production of HIV-1 neutralizing human monoclonal antibodies from lymphocytes obtained from seronegative donors
The design of an in vitro immunization system based on a synthetic heterotope immunogen, which was a peptide containing both T- and B-cell epitopes, that elicited a neutralizing, primary human humoral immune response against the human immunodeficiency virus (HIV-1) is reported here. This heterotope construct contained the major neutralizing B-cell epitope, within the V3 region of glycoprotein 120
A point mutation in a murine immunoglobulin V-region strongly influences the antibody yield in Escherichia coli
Recombinant DNA technology has made it possible to produce specific Fab and scFv antibody (Ab) fragments in prokaryotic host cells. Using vectors designed for periplasmic expression of encoded Ab fragments, we have been studying how the sequence and genetic localization of the light chain (L-chain) variable region gene of a mouse Ab (CB-Nm.1) determined the level of Ab production. The variable reg