Background and purpose Increased intradiscal pressure and relative segmental hypermobility are in vitro observations supporting the idea of increased postoperative load being a reason for progressive degeneration of the free mobile segment adjacent to a lumbar fusion. These mechanisms have been difficult to confirm in clinical studies, and an alternative theory claims instead that the adjacent seg

BACKGROUND: Those who die by suicide and suffer from depression are known to have made more suicide attempts during their life-span as compared to other people with depression. A behavioural sensitisation or kindling model has been proposed for suicidal behaviour, in accordance with a sensitisation model of depressive episodes. The aim of the present study was to test such a model by investigating

Metabolic and psychiatric disturbances occur early on in the clinical manifestation of Huntington's disease (HD), a neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin (HTT) gene. Hypothalamus has emerged as an important site of pathology and alterations in this area and its neuroendocrine circuits may play a role in causing early non-motor symptoms and signs in HD. Lepti

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This paper describes and analyses the political discourse regarding e-government (including terms earlier used) in Sweden in the period from the 1960s until today, drawing on a review of policy documents. It is found that even though both the meanings ascribed to computers, the political visions,and the main arguments have changed considerably over time, the majorplans for action have always remai

Promotion of new media industry has become a significant focus for regional development strategies, as it is generally believed that new media industry is a highly desirable form of economic activity. But is this really so? The question was put to a group of international researchers. The article which summarises their discussion and policy recommendations states that it is by no means clear that

Follicular dendritic cells (FDCs) are the antigen (Ag)-trapping accessory cells of the germinal centres (GCs), essential for the development of humoral immune responses and memory. FDCs reside in the microenvironment of secondary lymphoid tissue where Ag-activated B cells expand, and undergo isotype switching and affinity maturation prior to becoming memory B cells. In addition to delivering Ag, F

Popular Abstract in Swedish I Män, våld och moralarbete uppmärksammas hur män, som frivilligt sökt sig till verksamheter där det erbjuds behandling för våld i nära relationer, rapporterar om sina erfarenheter. Rapporteringarna består dels av svar på frågeformulär, dels genom deltagande i samtalsintervjuer. Författaren analyserar hur männen förklarar sina handlingar och gestaltar återberättade erfaMen, violence and moral work- Reports from help-seeking men at treatment centers working with violence in close relationships Men’s violence against women is an extensive social problem. In the 1970s, a new kind of centers were established in the US and UK, focusing on treating men who had been violent against their wives or girlfriends, the aim which is to end the men’s violent behavior. In the

OBJECTIVE: To study how the choice of national EQ-5D tariff may affect utility and incremental quality-adjusted life-year (QALY) estimates. METHODS: South Swedish rheumatoid arthritis patients in an observational study, starting and continuing anti-tumour necrosis factor (TNF) monotherapy (n=54) or anti-TNF plus methotrexate (n=215) for 1 year during May 2002 to April 2009, were included. EQ-5D q