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In both collagen-induced arthritis (CIA) and rheumatoid arthritis, T cells recognize a galactosylated peptide from type II collagen (CII). In this study, we demonstrate that the CII259-273 peptide, galactosylated at lysine 264, in complex with Aq molecules prevented development of CIA in mice and ameliorated chronic relapsing disease. In contrast, nonglycosylated CII259-273/Aq complexes had no suc
Three adult volunteers (2 males and I female) have ingested radioactive caesium in two edible forms in order to compare the gastrointestinal uptake and the subsequent short-term and long-term biokinetics. Foodstuffs made of fresh-water fish or mushrooms from regions in Sweden of high Cs-137 deposition was ingested together with a (CsCl)-Cs-134-solution mixed with soft drinks. Whole-body countings
The effects of i.v. calcitonin gene-related peptide (CGRP) on regional blood flow, vascular resistance, heart rate and cardiac output in cats were studied using the microsphere method. Three series of experiments were performed. In the first there was no pre-treatment of the animals. In the second the animals were pre-treated with indomethacin (5 mg kg-1) in order to prevent the formation of prost
Berättelser om medelålder står i centrum för rapporten. Genom en text - och diskursanalys av tidningen Tara, undersöks hur ett visst diskursivt fält skapas och bibehålls. Analysen tar sin utgångspunkt i feministiska och genusvetenskapliga teorier, samt antagandet att det som konstrueras i tidningen kan berätta något om rådande genusordningar. Analysen av berättelser i Tara visar att det finns fl
The mechanism of transmembrane polyamine internalization in mammalian cells remains unknown. A novel fluorescent spermidine conjugate [Spd-C(2)-BODIPY; N-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-propionyl)-N' -(S -[spermidine-(N(4)-ethyl)]thioacetyl)ethylenediamine] was synthesized from N(4)-(mercaptoethyl)spermidine by a simple, one-step coupling procedure. In Chinese-hamster ov
Purpose: To describe the treatment of cytomegalovirus (CMV) retinitis with intravitreal sustain-release ganciclovir devices in a 16-year-old patient in third remission of acute lymphoblastic leukemia after stem cell transplantation. METHODS: The patient received a stem cell transplant from an unrelated bone marrow donor after which he contracted a serious CMV infection manifested in the lungs and
Background: Impaction grafting in hip revision surgery is widely used but studies with mid- and long-term follow-up are scarce. Patients, methods and results A 5-year radiostereometric (RSA) follow-up of 15 hip revisions with the Exeter stem, morselized impacted allograft bone and cement revealed that 3 stems had not migrated between 2 and 5 years after revision, 11 stems had migrated to a minor
Using the eight-band k center dot p model and the Burt-Foreman envelope function theory to perform self-consistent calculations, we have studied the effect of electron-hole hybridization on the cyclotron masses m(*) and the effective g-factors g(*) of two-dimensional quasiparticles in InAs/GaSb quantum wells under a magnetic field applied perpendicular to the interfaces. We can modify the degree o
Background: Patients needs and experiences attract increasing attention within health care. In order to generate knowledge about the voices that emerge from collaborative experiences between members of patient associations for cancer patients ( PACP) and health care professionals (HCPs), we studied a permanent network aimed at improving cancer care through increased attention to the cancer patient
The interactions between charged alkylacrylamide gels of varying hydrophobicity and charge density and the oppositely charged surfactant hexadecyltrimethylammonium (C(16)TA(+)) have been investigated to determine the conditions necessary to induce excess surfactant binding (beyond charge neutralization) and resolubilization of the polymer-surfactant complex. In all cases, an initial gel collapse o
BACKGROUND: The gold standard to reconstruct a nerve defect is a conventional autologous nerve graft. There may be a lack of such grafts in severe nerve injuries. Alternatives to autologous nerve grafts are needed. METHODS: We have developed a technique where mainly Schwann cells are acutely dissociated from the ends of the severed nerve trunk after nerve injury. The technique does not require lon
We test whether mortality is related to individual income, mean community income, and community income inequality, controlling for initial health status and personal characteristics. The analysis is based on a random sample from the adult Swedish population of more than 40, 000 individuals who were followed up for 10-17 years. We find that mortality decreases significantly as individual income inc
The aim of this thesis was to prospectively evaluate the short-term effect of a non-steroidal anti-inflammatory drug (diclofenac sodium, Voltaren) and stabilisation appliance in controlled trials of patients with temporomandibular disorders (TMD) of arthrogeneous origin. The active treatments were compared to placebo in the study of diclofenac and to a control appliance in the other study. Thirty-
Neutron deficient nuclei close to Sn-100 have been studied using the NORDBALL Ge-detector array together with ancillary particle detectors. Evaporation residues from the compound nucleus Te-108 were identified with charged particle and neutron detectors. In this paper a considerable extension of the level scheme of the nucleus Cd-102 is presented. The strongest cascade of the new level scheme reve
