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Hereditary cystatin C amyloid angiopathy: Identification of the disease causing mutation and specific diagnosis by polymerase chain reaction based analysis

Hereditary cystatin C amyloid angiopathy (HCCAA) is a dominantly inherited disease characterized by amyloidosis, dementia and fatal cerebral hemorrhage of young adults. A method for rapid and simple diagnosis of HCCAA is described. It is based upon oligonucleotide-directed enzymatic amplification of a 275-bp genomic DNA segment containing exon 2 of the cystatin C gene from a blood sample, followed

Full-Color Emission and Temperature Dependence of the Luminescence in Poly-P-phenylene ethynylene-ZnS/Mn2+ Composite Particles

The synthesis of a nanocomposite material composed of anionic poly(phenylene ethynylene) (aPPE) polymer particles and ZnS/Mn2+ nanoparticles is described, and its luminescence properties are investigated. aPPE particles have two emissions, one in the blue (460 nm) and the other in the green (490 nm), that are assigned to the 0-0 transition and an excimer, respectively. ZnS/Mn2+ nanoparticles have

Prevalence of carpal tunnel syndrome in a general population

CONTEXT: Carpal tunnel syndrome (CTS) is a cause of pain, numbness, and tingling in the hands and is an important cause of work disability. Although high prevalence rates of CTS in certain occupations have been reported, little is known about its prevalence in the general population. OBJECTIVE: To estimate the prevalence of CTS in a general population. DESIGN: General health mail survey sent in Fe

Beyond neopositivists, romantics, and localists: A reflexive approach to interviews in organizational research

In this article I develop a framework for thinking about the research interview, and I critique dominating neopositivist and romantic views on the interview. I suggest eight metaphors that offer reconceptualizations of the interview, drawing upon recent theoretical trends on language, the subject, and discourse, and develop a reflexive theoretical framework. The article provides new ways of dealin

Biodiversity - Global biodiversity scenarios for the year 2100

Scenarios of changes in biodiversity for the year 2100 can now be developed based on scenarios of changes in atmospheric carbon dioxide, climate, vegetation, and Land use and the known sensitivity of biodiversity to these changes. This study identified a ranking of the importance of drivers of change, a ranking of the biomes with respect to expected changes, and the major sources of uncertainties.

The long-term consequence of anterior cruciate ligament and meniscus injuries: osteoarthritis.

The objectives of this study are to review the long-term consequences of injuries to the anterior cruciate ligament and menisci, the pathogenic mechanisms, and the causes. of the considerable variability in outcome. Injuries of the anterior cruciate ligament and menisci are common in both athletes and the general population. At 10 to 20 years after the diagnosis, on average, 50% of those with a di

The Distributional Implications of Agricultural Policies in Developing Countries - Findings from the Development Policy Evaluation Model (DEVPEM)

This chapter presents the Development Policy Evaluation Model (DEVPEM), a new simulation model which captures four critical aspects of rural economies in developing countries: 1) the role of the household as both a producer and a consumer of food crops; 2) high transaction costs of participating in markets; 3) market linkages among heterogeneous rural producers and consumers; 4) the imperfect conv

Classification of genomic and proteomic data using support vector machines

Supervised learning methods are used when one wants to construct a classifier. To use such a method, one has to know the correct classification of at least some samples, which are used to train the classifier. Once a classifier has been trained it can be used to predict the class of unknown samples. Supervised learning methods have been used numerous times in genomic applications and we will only

Crash Prediction Models for Intersections on Rural Multilane Highways: Differences by Collision Type

Accident prediction models are often used to predict the number of accidents on segments and at intersections in the road network. Most often the models are developed for a total number of crashes for the facility, or crashes by severity. However, the frequency and severity of crashes of different types can be expected to vary with regards to the underlying phenomena that cause them to occur. To b

The Culture of Information Systems in Knowledge-Creating Contexts: The Role of User-Centred Design

Examining communities in all their meanings, the paper locates User- Centred Design (UCD) in the amplified scope of approaches to Information Systems Design (ISD). Culture in communities is explained in structurational terms, in which human action and social structure (including ICT) interact to produce and reproduce the social patterning that both supports and constrains action. The widening of t

A detailed dynamical investigation of the proposed QS Virginis planetary system

In recent years, a number of planetary systems have been proposed to orbit-evolved binary star systems. The presence of planets is invoked to explain observed variations in the timing of mutual eclipses between the primary and secondary components of the binary star system. The planets recently proposed orbiting the cataclysmic variable system QS Virginis are the latest in this ongoing series of `

Flat colorectal tumours in a south Swedish population: A prospective chromoendoscopic and histopathological study.

Background: Flat and depressed colorectal tumours are common in Japan but are very rare or non-existent in Western countries. Aims: To study the occurrence of flat colorectal tumours in a southern Swedish population. Methods: In this prospective study, 371 consecutive European patients were examined by high resolution video colonoscopy combined with chromoendoscopy. The nature of the lesions was

Allelopathy in phytoplankton - biochemical, ecological and evolutionary aspects

It is considered self-evident that chemical interactions are a component of competition in terrestrial systems, but they are largely unknown in aquatic systems. In this review, we propose that chemical interactions, specifically allelopathy, are an important part of phytoplankton competition. Allelopathy, as defined here, applies only to the inhibitory effects of secondary metabolites produced by

The Light-dependent Magnetic Compass

Animals can detect different parameters of the geomagnetic field by two principal independent magnetoreception mechanisms: (1) a light-dependent process detecting the axial course and the inclination angle of the geomagnetic field lines, providing the animals with magnetic compass information (inclination compass), and (2) a magnetite-mediated process, providing magnetic map information (map sense

Who’s asking the right question? Patterns and diversity in the literature of new venture creation

The aims of this chapter are to (i) place the research on new venture creation into the historical context of entrepreneurship research in general, (ii) highlight the pioneering works of William Gartner, and (iii) describe the development and characteristics of the research on new venture creation as an area within entrepreneurship research. The discussion in the chapter is mainly based on a set o