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The haemostatic effect of by-passing agents such as activated prothrombin complex concentrates (aPCC) and recombinant factor VIIa is inadequate in some patients with severe haemophilia and high-responding inhibitors. Theoretically, this could be due to antibody reactivity to procoagulant proteins other than the deficient factor. To evaluate this hypothesis, immunoglobulin (Ig) fractions from six m
OBJECTIVE: Periodontal ligament (PDL) cells express oestrogen receptor beta (ERbeta) protein, but cellular functions regulated by ERbeta in these cells have not been identified. In this study we determine if ERbeta is localised to mitochondria and if oestrogen regulates mitochondrial function in human PDL cells obtained from teeth extracted for orthodontic reasons. DESIGN: Subcellular distribution
Our knowledge of neuroprotective factors important for the adult enteric nervous system is poor. Changes in expression of vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) in enteric neurons in response to neuronal injury or colchicine treatment, as well as in intestinal adaptation, have been described. Cultured myenteric neurons increase their expressi
We present a detailed study of the electronic structure and the stability of C-60 dianions in the gas phase. Monoanions were extracted from a plasma source and converted to dianions by electron transfer in a Na vapor cell. The dianions were then stored in an electrostatic ring, and their near-infrared absorption spectrum was measured by observation of laser induced electron detachment. From the ti
We investigate the implication of uncertainties in the unintegrated gluon distribution for the predictions for central exclusive production of scalars at hadron colliders. We use parameterizations of the k(perpendicular to)-unintegrated gluon density obtained from the Linked Dipole Chain model, applying different options for the treatment of non-leading terms. We find that the luminosity function
Interviews with six couples, persons with Parkinson's disease and their partners, were tape-recorded, transcribed and analysed using manifest and latent content analysis. The couples' experiences could be interpreted as Being in the light and Being in the shade of support, with internal variations for the patients and their partners. The narratives also revealed that the disease meant a transition
Copolymerization of N-acryloyl-m-aminophenylboronic acid (NAAPBA) with acrylamide (AAm) on the surface of glass plates resulted in the formation of a hydrogel film with porous structure and capable of optical response to the changes in concentration of glucose in the contacting solution. The boronate specific dye, Alizarin Red S (ARS) was incorporated into hydrogel film to increase the sensitivity
We have applied and evaluated system identification methods using both commercial software and dedicated subspace model identification software (MOESP). Results using the different software tools have been similar (but not identical) in accuracy and predictive power, the main differences being the time required for computation and occasional failures of one algorithm in delivery of a stable model.
A spherical reference field is used to construct a digital holographic system with a demonstrated resolution up to 228 line pairs per mm. The reference field originates from a GRIN lens placed 1 mm from the illuminated object. This allows the use of a standard sensor to record the hologram with the required numerical aperture. The image is determined by evaluation of the Rayleigh–Sommerfeld diffra
Kinetic measurements at low temperatures (310-360 K) using gas chromatography (GC) for benzene hydrogenation on Pt(100) and Pt(111) single crystal surfaces have been carried out at Torr pressures. These kinetic measurements demonstrated a linear compensation effect for the production of cyclohexane. A detailed application of the model of selective energy transfer to the experimentally obtained res
One major problem in global governance is the specification of decision-making rules for international and regional organisations to coordinate the states of the world. Various organisations use different decision-making rules, and the properties of these rules may be compared systematically in terms of the power index approach. The power index solution concept of N-person games may be employed to
Molecular interaction between host mucosal surfaces and outer membrane components of microbes is crucial in the infection process. The outer membrane of pathogenic Neisseria contains surface molecules such as pili, PilC, and Opa and a monolayer of lipooligosaccharide (LOS), all of which are involved in the interaction with host cells. Pili mediate the initial attachment to human epithelial cells,
Absorption spectra of a series of cyclic conjugated ketones and thioketones have been computed at the multiconfigurational second-order multistate perturbation level of theory, the CASSCF/MS-CASPT2 method. Excitation energies, transition dipole moments, oscillator strengths, and static dipole moments are reported and discussed for excited states with energies lower than approximate to7-8 eV. The m
We have used the x-ray magnetic circular dichroism technique to characterize ultrathin Co films deposited on flat and vicinal Cu(111) single crystal surfaces. All films were prepared and characterized in situ, in ultrahigh vacuum. Similar to other investigators we report a 40% increase of the ratio m(l)/m(s) (orbital to spin moment) of ultrathin Co on both flat and vicinal Cu(111). In addition, an
The concept of disability-adjusted life years (DALYs) has rapidly gained in popularity in health policy, and considerable research resources are being allocated to this field. Proponents of DALYs suggest that the measure can be used both as a "gross domestic product of health" and to help in setting priorities in health policy. This study investigates the usefulness of DALYs and contends that DALY
