A theoretical study is reported of metallic hydrogen in the molecular phase of Cmca-4 and the atomic phase of I4_1/amd at high pressure about 500 GPa. Using density functional theory (DFT) and more specifically the PBE exchange correlation functional as approximation scheme, the crystal structure of metallic hydrogen has been investigated. This to determine its metallic properties and see if the c

Maf transcription factors have pivotal roles in regulating beta cell function and development, and loss of MafA expression has been associated in inducing pro-inflammatory gene signature. This study assessed if the loss of MafA transcription factor expression contributes to the development of islet inflammation. Immunohistochemical analysis showed that 8 months old MafA deficient pancreata (MafA-/

Kan cellers proteiner bota HPV- sjukdomar? Livmoderhalscancer är en av de vanligaste cancersjukdomarna som drabbar kvinnor världen över. Varje år, diagnostiseras ungefär 500 000 kvinnor och 270 000 dör i sjukdomen, varav de flesta dödsfallen sker i utvecklingsländer. Livmoderhalscancer orsakas av det vanligt förekommande viruset humant papillomvirus (HPV) och för att hitta bättre behandling mot sHuman papillomaviruses (HPVs) are small DNA viruses that have evolved over millions of years and are well-adapted to humans. Persistent infections with HPVs, can result in cancer development. There are over 200 different HPV types that can be divided into high- and low risk types based on their ability to cause cancer. HPV16 is the most common high- risk type that accounts for more than 50 % of al

In recent years, overall survival was significantly prolonged in Mantle Cell Lymphoma (MCL) patients due to improved treatment regimen. However, there is still a subgroup of patients that relapse after a short time. Better understanding of the underlying genetic and non-genetic events can be used to achieve personalized medicine for each patient. MCL is associated with the translocation t(11;14)(q

Neurala progenitorceller kan rädda din mentala hälsa Ett utsträckt mänskliga genom hade varit nästan 2 meter långt och kräver därför sofistikerade packningsmetoder för att få plats i en organisms alla celler. Ett viktigt protein för detta ändamål är Heterokromatin Protein 1 (HP1) som paketerar genomet till en struktur som kallas Heterokromatin. Denna kompakta form av genomet är inte bara ett sät

Market concept such as sustainability, CSR and sustainable food have influenced the way in which actors on the marketplace behave. Furthermore, previous research have shown that while some market concepts and logics succeed in becoming established among market actors other do not. This in turn has significant consequences on how the market is structured and the behavior of different actors within

Drawing on Nye’s concept of soft power, this thesis discusses the strategic adoption of a rhetoric of Ecological Modernization as a discursive tool of public diplomacy. It makes use of the upcoming 2020 Tokyo Olympic Games as a case study. Indeed, the increased perceived value of sport mega-events in promoting soft power suggests a political instrumentality in hosting such events. This thesis empl

This thesis examines North Korean migrants’ agency over the objective constraints caused by their categorization as ‘defectors’. By analyzing the direct accounts of three North Korean artists residing in South Korea, this thesis explores the mechanisms they employ to develop their artistic career in a context where their identity is labelled. Current literature on North Korean migrants’ social ada

The primary aim of this thesis is to analyze and uncover stereotypes concerning Caucasian westerners among Japanese citizens. This is done by looking into recent Japanese cinema in order to analyze how Caucasian westerners are displayed in the movies in which they appear. A semiotic approach as defined by Jonathan Bignell is used in order to gather data from the selected movies, and the findings d

This bachelor thesis analyzes how the fashion house Chanel has been through a transformation in the concept of fashion shows, by analyzing six different video recordings of shows between 1994 and 2018. Caroline Evans describes today’s fashion shows as spectacles that no longer have the purpose of marketing for increased sales but rather a need to entertain the audience by theatrical performances.

Apolipoprotein A-I (ApoA-I) is the most predominant protein of high-density lipoprotein (HDL), which is an essential component for reverse cholesterol transport (RCT). ApoA-I has many health-promoting functions, such as anti-atherosclerosis and antioxidant properties; however, carriers of certain rare mutations in the APOA1 gene suffer from a disease called hereditary ApoA-I-related amyloidosis. A

LL-37 peptidens roll i det orala immunsystemet Munhålan exponeras för en stor mängd bakterier varje dag, vilket gör det viktigt att ha ett fungerande immunförsvar. Vid kariesangrepp urlakas mineraler från tandens hårda vävnader (dentin) på grund av lokala pH-sänkningar orsakade av bakterier i munhålan. De första cellerna som bakterierna stöter på när de invaderar och bryter ner tandsubstans kalla

This study aims to summarize some of the climate change related challenges for city centers in Sweden by using the city Helsingborg as an example. The approach is wide and includes three different dimensions: City planning, shopping in city centers and mobility. By doing so the reader will see climate change related challenges from different perspectives which all affect each other. Shopping and m

The human epidermal growth factor receptor 2 (HER2) is a receptor tyrosine kinase that is involved in many cellular pathways. The HER2 locus is amplified in 12-21% of all breast cancers and is associated with poor prognosis. The introns of HER2 contain two non-coding RNAs: a microRNA (miRNA) named mir-4728 and a box C/D snoRNA-like molecule thus far named snoID_0714. In this study, a list of targe

Office space is a vital element of every organization. Additionally, there is an ongoing debate on how to utilize office space most effective to maximize occupancy while providing an efficient work environment for employees. Because office space is the daily work environment for many people, in which they spend a tremendous amount of their time, office space can exert a considerable impact on thei

The regional disparities in China are increasing, at the same time as the growth moderates. In order to keep successful development in the future, China is rapidly developing the rail infrastructure, as one of the main channels to obtain a balanced regional development. The argument is that regional inequalities will decrease through increased economic interconnection and mobility provided by the

The study of high-quality genomic sequences from great-apes, our closest relatives and one of the most relevant to understand human bio-logical processes, is reaching a limit in terms of access. New methods are needed to achieve the maximum variant information from lower-quality samples. In that scenario, imputation is shown as a good candidate for improving genotype information on low-genotyped d

The purpose of this to study is to identify factors that influence how a concept store format contributes to a format portfolio, which will be done by exploring the concept store format from three perspectives; customers, manager, and industry experts. Philosophies of epistemology and ontology were considered, where the social constructionism stance was employed. Additionally, the research followe

With the aim of widening the picture of a Late Iron Age warrior society in central Blekinge by studying the social role of its women, female cremation burials have been identified and their material studied. Artefacts and their combinations have been interpreted and their suggested meanings compared with contemporary iconography as well as with Anglo-Saxon and Norse literary sources. The grave mat

Atherosclerosis, a chronic inflammatory condition, is the main attributor to cardiovascular disease. As such, elucidating the underlying immunological events that occur during atherogenesis has become an area of interest to better understand atherosclerotic pathology. T cells are an integral component of the adaptive immune response and have been shown to be present in atherosclerotic plaques. How