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1. Measurements of cell capacitance were used to investigate the mechanisms by which acetylcholine (ACh) stimulates Ca2+-induced exocytosis in single insulin-secreting mouse pancreatic B-cells. 2. ACh (250 microM) increased exocytotic responses elicited by voltage-clamp depolarizations 2.3-fold. This effect was mediated by activation of muscarinic receptors and dependent on elevation of the cytopl

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The growth arrest-specific gene 6 product (Gas6) is a secreted protein related to the anticoagulant protein S but its role in hemostasis is unknown. Here we show that inactivation of the Gas6 gene prevented venous and arterial thrombosis in mice, and protected against fatal collagen/epinephrine-induced thrombo embolism. Gas6-/- mice did not, however, suffer spontaneous bleeding and had normal blee

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Protein kinase C (PKC) is a family of serine/threonine kinases, which are subgrouped into classical (a, bI, bII, g), novel (d, e, h, q) and atypical (z, i/l) isoforms. One major aim of this thesis work was to investigate if altered levels of PKC isoforms influence the apoptotic responses of malignant cell-lines. We show that overexpression of PKCd or PKCq renders SK-N-BE(2) neuroblastoma cells sen

The objective of this thesis is to numerically simulate a fluid jet injected into a crossflow of the same or another fluid, respectively. Such flows are encountered in many engineering applications in which cooling or mixing plays an important role, e.g. gas turbine combustors. The jet in crossflow (JICF) is used both for cooling and for injecting liquid fuel into the air stream prior to combustio

Discussions about values are common in many contexts. Often, what is debated is the choice of means to realize or protect various values, but sometimes the discussion concerns the very values that ought to be realized or protected. Philosophical debate in this area has mainly been focused on two kinds of issues. Philosophers have tried to identify the set of fundamental values, i.e., to provide wh

Quality of movement assessment using the Body Awareness Scale–Health (BAS-H) was validated against the following self-rating tests: Nottingham Health Profile (NHP); Arthritis Self-Efficacy Scale (ASES); Psychological General Well-Being (PGWB); Sense of Coherence (SoC); Sivic Psychosomatism test (SPS); Symptom Check List 90-R (SCL 90-R); and Visual Analogue Scale for pain intensity (VAS-pain). In t

An important signal involved in glucose-stimulated insulin secretion is transduced through the action of a lysosomal acid, glucan 1,4-alpha-glucosidase. We investigated the Ca2+ dependency of this enzyme activity in relation to insulin release. In isolated islets, increased levels of extracellular Ca2+ induced a large increase in acid glucan 1,4-alpha-glucosidase activity accompanied by a similar

IDDM is positively associated with HLA-DQA1*0301-DQB1*0302 (DQ8) and DQA1*0501-DQB1*0201 (DQ2) and negatively associated with DQA1*0102-DQB1*0602 (DQ6). The aim of the present study was to analyze the importance of several polymorphic residues and domains of DQalpha and DQbeta, in addition to residue 52 DQalpha and residue 57 DQbeta, with regard to susceptibility or resistance in new-onset 0- to 1

Phononic and magnetic Raman scattering are studied in La2-x-yNdySrxCuO4 with three doping concentrations: x1/8, y = 0; x1/8, y = 0.4; and x = 0.01, y = 0. We observe strong disorder in the tilt pattern of the CuO6 octahedra in both the orthorhombic and tetragonal phases that persist down to 10 K and are coupled to bond disorder in the cation layers around 1/8 doping independent of Nd concentration

It has been predicted theoretically that for some environments, the capacity of wireless multiple-input multiple-output systems can become very low even for uncorrelated signals; this effect has been termed "keyhole" or "pinhole." In this letter, We present the (to our knowledge) first measurement of this effect. The measurements are done in a controlled indoor environment, with transmitter and re

This paper presents a symbol time offset estimator for coherent orthogonal frequency division multiplexing (OFDM) systems. The estimator exploits both the redundancy in the cyclic prefix and available pilot symbols used for channel estimation. The estimator is robust against frequency offsets and is suitable for use in dispersive channels. We base the estimator on the maximum-likelihood estimator

Review of Bjarne Stoklund (ed.), Kulturens nationalisering. Et etnologisk perspektiv på det nationale, dealing with matters of nationalism.

The refugee families face a complex transition due to the nature of the migration. This exposes them to vulnerability in cohesion and family function. Primary Health Care Nurses (PHCN) and Interpreters in Primary Health Care (PHC) play a vital role in their promotion of health because migrant health care is mainly carried out within PHC. The overall aim of this thesis was to reach a comprehensive

Five intersecting resistivity sections have been measured in glaciofluvial deposits hosting an aquifer of regional importance situated along a heavy traffic highway in Sweden. The winter salt spreading has caused a regular salinity increase through the years. For imaging the transport of saltwater in the aquifer, the sections were measured exactly in the same location before and after winter, and

Background: Passive immunization with orally administered antibodies against specific pathogens has previously been successfully used therapeutically in both animal and human studies. We employed a similar strategy for experimental treatment of mice infected with the gastric pathogen Helicobacter pylori. Methods: An anti-H. pylori bovine colostral hyperimmune immunoglobulin preparation (BIC) was g

The surface of the ocean, and so such quantities as the significant wave height, can be thought of as a random surface in space which develops over time. In this paper, we explore certain types of random fields (in space and time) as models for the significant wave height and fit these models to data obtained from the TOPEX-Poseidon satellite. The data consist of observations along different one-d