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Marine-derived nutritional and bioactive compounds : Proteins and amino acids

Marine ecosystems are consisted with variety of life, accounting for over 80% of the Earth's biodiversity. This rich biodiversity in marine environment includes more than 30,000 species of fish. Additionally, marine biological resources are reservoirs of numerous bioactive compounds with various physiological functions such as antioxidant, anti-inflammatory, anticancer, antiaging, antibacterial, a

Subventricular Zone-on-a-Chip : A Model to Study Neurogenesis Disruption in Neonatal Intraventricular Hemorrhage

Intraventricular hemorrhage (IVH) in preterm infants disrupts neurogenesis in the subventricular zone (SVZ), a key neurogenic niche, yet no effective treatments exist. This work develops a human SVZ-on-a-chip model to investigate the inflammatory response in IVH and its impact on neurogenesis. Using this platform, this work examines the effects of red blood cell lysate (RBCL) and hemorrhagic cereb

Long-term neurodevelopmental outcomes in extremely preterm infants born at 22–26 weeks gestation : a follow-up of 2–2.5 years across two Swedish national cohorts from 2004–2007 to 2014–2016

Objective To compare neurodevelopmental outcomes in extremely preterm (EPT) children born across two epochs in Sweden. Design and setting Nationwide population-based cohorts of infants born at 22–26 weeks’ gestation in 2004–2007 (Cohort 1) and 2014–2016 (Cohort 2), comprising 1606 live births. Survivors were assessed at 2–2.5 years’ corrected age using the same protocol design. Main outcome The pr

Lignans and neolignans from the twigs and leaves of Wikstroemia indica (L.) C.A. Mey. with their effects on LPS-induced IL-1β and IL-10 secretion in RAW 264.7 macrophages

Eight compounds were isolated from the water-soluble fraction of Wikstroemia indica (L.) C.A. Mey., including two new neolignans (isonitidanin-4-O-β-D-glucoside (3) and threo-citrusin B (6)), four known neolignans (1, 2, 4, and 5), along with two previously reported lignans (7 and 8). Spectral analysis (1D, 2D NMR, and HR-ESI-MS/MS) was used to identify their chemical structures. Except for compou

Assessment of elevated road traffic pollution on roadside trees and vegetation in urban environments

Road traffic pollution is one of the most important factors among other environmental factors that influence the roadside vegetation. The present research examines the impact of motorway flyovers and at-grade roads on air pollution (PM10, SOx, NOx, and air quality index (AQI)) and roadside vegetation in Dehradun by considering the important biochemical parameters such as chlorophyll, ascorbic acid

Visions of life with less mobility. Can the doughnut model gain legitimacy?

Avoiding exceeding planetary boundaries, while still achieving a decent standard of living for all is a global challenge represented in the so-called doughnut model. Policies for local mobility in line with the doughnut model, will lead to less and slower mobility for many people. This paper contributes to doughnut literature with insights regarding people’s visions of life with doughnut-inspired

Metabolic reprogramming in diabetes and other endocrine and metabolic disorders : exploring the Warburg effect, ketones, and SGLT2 inhibitors

The “Warburg effect”, a metabolic adaptation observed in dividing cells, involves a shift from mitochondrial oxidative phosphorylation to cytoplasmic glucose metabolism. This metabolic process is characterized by increased cellular uptake of glucose and glutamine, elevated intracellular pH and sodium levels, enhanced protection against oxidative stress, altered autophagy, and increased lactate pro

Angloamerikanska standardklausuler i svensk kommersiell avtalsrätt

Syftet med denna framställning är att, med utgångspunkt i ett par valda bestämmelser av boilerplate-karaktär, undersöka klausulernas rättsverkningar utifrån ett svenskt avtalsrättsligt perspektiv. Boilerplate-klausuler anses skapa förutsebarhet mellan kommersiella avtalsparter och ger uttryck för generella bestämmelser som inte är avtalsspecifika. Det som emellertid är problematiskt för svenskt viThe purpose of this paper is to analyze boilerplate-clauses from a Swedish contract law perspective. Boilerplate-clauses are widely recognized for their role in enhancing predictability in commercial contracts, providing standardized terms that are not tailored to the specifics of an individual agreement. However, a challenge arises from the fact that these clauses originate from Anglo-American le

Orsaksbegreppet och alternativa dödsorsaker - En analys av det straffrättsliga orsaksbegreppet i ljuset av NJA 2024 s. 36

Det straffrättsliga orsaksbegreppet har främst diskuterats i rättsvetenskaplig doktrin, eftersom det saknas en legaldefinition och mängden rättspraxis kring begreppet är begränsad i Sverige. År 2024 kom dock ett avgörande, NJA 2024 s. 36, där Högsta domstolen för första gången uttryckligen diskuterade orsaksbegreppet. Rättsfallet handlade om alternativ kausalitet i form av alternativa dödsorsakThe concept of causation in criminal law has been discussed mainly in legal doctrine, since there is no legal definition, and the amount of case law regard ing the concept is limited, in Sweden. In 2024, a decision was made, NJA 2024 s. 36, where the Swedish Supreme Court explicitly discussed the con cept of causation for the first time. The case was about alternative causality in the terms of