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BackgroundIntravenous immunoglobulins (IVIG) have been suggested as an adjunctive treatment in streptococcal toxic shock syndrome (STSS), but there are no conclusive trials. In southern Sweden, IVIG is routinely used in certain hospitals but not in others. We hypothesized that this would resemble a natural experiment, and aimed to evaluate the effect of IVIG in STSS patients.MethodWe conducted a p

Carbon sequestration in arable soils is gaining increasing attention in global policymaking initiatives for climate-change mitigation. Large-scale assessments of soil organic carbon development in arable land are affected by the scarcity of reliable time series of soil organic carbon monitoring data and often fail to replicate observed trends or appreciate any effects induced by changes in soil ma

Vi möter dagligen larmrapporter om att den regelbaserade världsordning som etablerades efter andra världskriget håller på att bryta samman. För den som vill få en förklaring till varför detta händer och en hum om vart världen är på väg finns en färsk analys att tillgå i Eswar Prasads The Doom Loop, i svensk översättning ungefär ”domedagsspiralen”.

The study investigates how the Best Interests of the Child principle in the UN Children's Rights Convention (Article 3) has been adapted in custody disputes in Egypt, Sweden, and Uzbekistan. Although the Convention on the Rights of the Child offers a common normative benchmark, divergent legal cultures shape its domestic meaning: Egypt is governed by religious and state legal norms intersecting wi

Patients with pulmonary arterial hypertension (PAH) experience long diagnostic delays, high functional class at diagnosis and poor prognosis. We aimed to study the differentiative and predictive value of 90 inflammatory and immunomodulatory related proteins in idiopathic and hereditary PAH (IPAH/HPAH) and systemic sclerosis-associated PAH (SSc-APAH). Cohort 1 comprised patients with SSc-APAH ( n =

Naturbetesmarker och slåtterängar är bland de mest artrika miljöerna i det svenska jordbrukslandskapet och har därför en avgörande betydelse för bevarandet av biologisk mångfald. För att uppfylla kraven i EU:s Naturrestaureringsförordning och de nationella miljökvalitetsmålen krävs att Sverige både bevarar befintliga gräsmarker med höga naturvärden och restaurerar betydande arealer så att de erhål

ObjectivesPeople with serious illness approaching end of life often end up in emergency and hospital care, frequently against expressed preferences. Consequently, oncology trials record care days as a measure of treatment burden called “time toxicity.” However, this measure ignores the diminishing marginal utility of time: that the value of a day is higher when fewer remain. We aimed to incorporat

Iran’s extraterritorial violence constitutes a structural element of state policy, implemented through a coordinated system of intelligence services, diplomatic platforms, proxy militias, and criminal intermediaries. Rooted in revolutionary doctrine and operationalized by institutions such as the Islamic Revolutionary Guard Corps (IRGC) and its external arm, the Quds Force, this apparatus has enab

This master’s thesis explores the impact from the fire investigations by the Swedish Accident Investigation Authority (SHK) on fire safety in Sweden. Through a mapping survey and a qualitative interview study, it is found that it is often difficult to identify clear connections between the investigations’ safety recommendations and real improvements to fire safety, due to long time spans and multi

Background: In a recently discovered microorganism, Halomonas boliviensis, polyhydroxybutyrate production was extensive and in contrast to other PHB producers, contained a set of alleles for the enzymes of this pathway. Also the monomer, (R)-3-hydroxybutyrate (3HB), possesses features that are interesting for commercial production, in particular the synthesis of fine chemicals with chiral specific

Polyhydroxyalkanoates (PHAs), as bio-based plastics, promise a transition from petroleum products to green and sustainable alternatives. However, their commercial production is yet impeded by high production costs. In this study, we assessed synthetic culture in mono and co-culture modes for bacterial PHA production. It was demonstrated that volatile fatty acids (VFAs) derived from food waste and

Wastewater-based surveillance (WBS) allows the analysis of pathogens, chemicals or other biomarkers in wastewater to derive unbiased epidemiological information at population scale. After re-gaining attention during the SARS-CoV-2 pandemic, the field holds promise as a surveillance and early warning system by tracking emerging pathogens with pandemic potential. Expanding the current toolbox of ana

Human adenovirus (HAdV) type F41 has been identified as a possible cause of the non-A-to-E hepatitis outbreak. This study uses wastewater monitoring to track HAdV F40 and F41, supporting clinical investigations and providing insights into the pathogen's role in the outbreak. Given the limited clinical monitoring in Sweden of HAdV-F40/41, this approach also helps estimate the true infection burden

IntroductionSport-related concussion (SRC) is a pressing issue in Para sport, yet biomechanical mechanisms remain poorly understood. Athletes with visual impairment face elevated risks due to sport-specific demands, such as frequent collisions in blind football. This pilot study examined head acceleration responses in blind football players compared with non-disabled football players, and between

The chiral compound (R)-3-hydroxybutyrate (3HB) is naturally produced by many wild type organisms as the monomer for polyhydroxybutyrate (PHB). Both compounds are commercially valuable and co-polymeric polyhydroxyalkanoates have been used e.g., in medical applications for skin grafting and as components in pharmaceuticals. In this paper we investigate cultivation strategies for production of 3HB i

Background: Alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) are frequently comorbid and are individually associated with increased risk of suicidal behavior. However, whether their comorbidity exacerbates this risk has not been adequately investigated. Methods: Using a Swedish birth cohort (born 1970–1990; N = 799,203–858,983), we employed Aalen’s linear hazards models to evalu

In three empirical studies, we compare one syntactic and one semantic approach to agreement preferences in so-called pancake constructions (pcs) in Swedish, as in Senap är starkt ‘Mustard is strong’.pcs are either substance-denoting, naming an inherent property of the subject, or situation-denoting, naming a property of the subject that is linked to some event. These two types were found to differ