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Extreme Value Theory (EVT) is the state-of-the-art method for proactive prediction of accident frequency from traffic interactions on a microscopic scale. The main advantage of using EVT is to predict unobserved critical events based on one or more Surrogate Measures of Safety (SMoS) (single- or multivariate EVT) through a mathematical extrapolation of extreme interactions. Such interactions are q
The significance of the great ape heritage to the evolution of human rhythmic competence — as manifested in speech, music and dance — has been greatly underestimated in both past and contemporary research. In this chapter we deconstruct received misconceptions about the rhythmic competence of the apes and defend the position that, contrary to the received view, the great apes likely constitute the
The purpose of this project was to find estimates of the operational releases of 14C and 3H from new SMR technology that is being considered in Sweden, namely the Rolls-Royce SMR and the GE-Hitachi BWRX-300. To achieve this goal, models of the reactors of interest were made in the continuous-energy Monte-Carlo neutron and photon transport code Serpent, where the production of 14C and 3H could then
In mouse early pachytene spermatocytes, the X and Y chromosomes undergo rapid non-homologous (NH) synapsis and desynapsis, but the functional significance remains unknown. Here, we report that pachynema-specific knockout of Speedy A (SpdyA) from telomeres caused persistent Y-X NH synapsis, with the entire Y axis synapsed onto the X axis. This persistent Y-X NH synapsis did not interrupt meiotic se
Fan engagement on social media platforms presents significant challenges for digital preservation due to their dynamic and evolving character, spurred by the platforms’ data-generative and algorithmic features, as well as commercial logic. These characteristics pose problems when capturing information about the context of fan engagement. Context sheds light on the environment, setting or circumstaFan engagement on social media platforms presents significant challenges for digital preservation due to their dynamic and evolving character, spurred by the platforms’ data-generative and algorithmic features, as well as commercial logic. These characteristics pose problems when capturing information about the context of fan engagement. Context sheds light on the environment, setting or circumsta
Compassion fatigue (CF), a diminished empathic capacity resulting from prolonged exposure to others’ distress, is an emerging concern in the teaching profession. This study investigates the prevalence and predictors of CF among Swedish teachers, with a particular focus on reduced compassion toward students. Drawing on the job demands-resources model and the compassion fatigue resilience model, we
The concept of the rule of law has been a central issue in China for the past two decades, gaining even greater prominence under Xi Jinping’s leadership. This article examines the development of the rule of law in China, drawing on insights from local Chinese scholarship as a vital source for understanding the situation. By analyzing the most cited research articles in the China National Knowledge
Ideas on the (human) body, gender, and identity lie at the core of many socio-political issues and cultural trends in Asia today, while also inspiring innovative research on artistic expression from Asia's past. By focusing on socio-political as well as cultural issues from diverse geographical and historical contexts, this book highlights complex links and interactions that bind these three inter
Consider a sample of apparently unrelated individuals, for which marker genotype and phenotype data is available. When individuals are sampled on phenotypes, we propose an ascertained ancestral recombination graph (ARG) that models shared ancestry of the sample chromosomes given phenotype data along a region that possibly harbors a disease susceptibility gene. The ascertained ARG is used to define
Probing the internal structure of crystalline materials is vital for understanding and optimizing their functional properties, especially in semiconductors and multiferroics, where nanoscale distortions such as strain and lattice tilt can dramatically affect performance. Among various characterization tools, X-ray diffraction imaging offers a unique combination of deep penetration, nondestructive
Konstruktiv länkning, studentaktivitet och föreläsningar är tre grundstenar i högre utbildning. Men föreläsningen som undervisningsform har kritiserats: ”Det finns gott om högskolepedagogisk litteratur som förklarar varför föreläsningen är olämplig för att stimulera lärande. Ändå fortsätter vi föreläsa”, skriver Andreas Håkansson (2017, s. 40) i en artikel som trots allt landar i att denna undervi
PURPOSE The ESPAC4 trial showed that adjuvant chemotherapy with gemcitabine plus capecitabine (GemCap) produced longer overall survival (OS) than gemcitabine monotherapy. Subsequently, the PRODIGE24-CCTG PA.6 trial showed even longer survival for modified fluorouracil, folinic acid, irinotecan, and oxaliplatin (mFOLFIRINOX) than gemcitabine but had more restrictive eligibility criteria. Our aim wa
Ultra-hot Jupiters, an extreme class of planets not found in our Solar System, provide a unique window into atmospheric processes. The extreme temperature contrasts between their day and night sides pose a fundamental climate puzzle: how is energy distributed? To address this, we must observe the three-dimensional structure of these atmospheres, particularly their vertical circulation patterns tha
The formation of nitrogen- and sulfur-containing organic compounds (N-Org and S-Org) is important for atmospheric secondary organic aerosol (SOA) production, thereby influencing air quality and global climate. However, the mechanisms underlying N-Org and S-Org formation on aerosol particle surfaces are poorly understood due to the limited availability of surface-sensitive analytical techniques. Th
Aviation contributes to air pollution and significantly impacts climate change. Sustainable aviation fuels (SAFs) offer a potential solution to reduce CO2 emissions with the possible co-benefit of reducing emissions of particles. This study evaluates emissions of a turbojet engine using conventional Jet A1 fuel, Biojet fuel (alcohol-to-jet synthetic kerosene with aromatics, ATJ-SKA), hydrotreated
Purpose: Identifying biomarkers of radiotherapy (RT) response is important for optimizing the treatment of early breast cancer. In this study, we tested the interaction between endothelial cell (EC) expression of phospho-Tyr397-FAK (pY397-FAK) and adjuvant-RT on clinical outcomes after breast-conserving surgery (BCS) within a randomized study. Preclinical data suggest an enhanced effect of RT on l
