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Allogeneic HSCT represents the only potentially curative treatment for very high risk (VHR) ALL. Two consecutive international prospective studies, ALL-SCT-(I)BFM 2003 and 2007 were conducted in 1150 pediatric patients. 569 presented with VHR disease leading to any kind of HSCT. All patients >2 year old were transplanted after TBI-based MAC. The median follow-up was 5 years. 463 patients were tran
This thesis explores the fire service workplace through full-scale experiments. Evidence-based information has been developed to be combined with firefighter experience to improve their knowledge of fire dynamics and the cause and effect impact of their tactics on life safety, property conservation, and incident stabilization. Multiple series of experiments examined how residential fire dynamics c
We present three-dimensional measurements of particle-size-dependent acoustophoretic motion of micropar- ticles with diameters from 4.8 μm down to 0.5 μm suspended in either homogeneous or inhomogeneous fluids inside a glass-silicon microchannel and exposed to a standing ultrasound wave. To study the crossover from radiation force dominated to streaming dominated motion as the particle size is dec
Background Juvenile idiopathic arthritis (JIA) is an umbrella term of inflammatory joint diseases in children. Oligoarthritis is the most common form in the Western world, representing roughly 60% of all patients. Monocytes and macrophages play an important role in adult arthritides, but their role in oligoarticular JIA is less studied. Polarization highly influences monocytes’ and macrophages’ ef
Severe infections continue to constitute a large burden, with high mortality and risk of sequelae. Sepsis is a dysregulated host response to an infection that causes life threatening organ damage. Meningitis is a severe infection of the brain that often leads to sepsis and death or lasting neurological damage. The host response is often responsible for more damage than the pathogen itself. This th
Background Increased vascular permeability is a key feature in the pathophysiology of sepsis and the development of organ failure. Shedding of the endothelial glycocalyx is increasingly being recognized as an important pathophysiological mechanism but at present it is unclear if glypicans contribute to this response. We hypothesized that plasma levels of glypicans (GPC) are elevated in patients wi
Background Acute bacterial meningitis is a disease with a high mortality and a high incidence of neurological sequelae in survivors. There is an acute need to develop new adjuvant therapies. To ensure that new therapies evaluated in animal models are translatable to humans, studies must evaluate clinically relevant and patient-important outcomes, including neurological symptoms and sequelae. Meth
Boken bygger på de grundläggande värderingar och begrepp som socialtjänstlagstiftningen vilar på. Vidare finns både bakgrund och kommentarer till lagarna inom socialtjänstens område och de övriga lagar och förordningar som ansluter till dessa. Denna klassiker föreligger nu i sin 14:e upplaga och är grundligt reviderad av Monica Larsson, jurist och universitetslektor i socialt arbete. Den nya upplaBoken bygger på de grundläggande värderingar och begrepp som socialtjänstlagstiftningen vilar på. Vidare finns både bakgrund och kommentarer till lagarna inom socialtjänstens område och de övriga lagar och förordningar som ansluter till dessa. Denna klassiker föreligger nu i sin 14:e upplaga och är grundligt reviderad av Monica Larsson, jurist och universitetslektor i socialt arbete. Den nya uppla
State reforms adopted in the 1680s prevented the largest copperworks in the Oldenburg Monarchy, Røros, from shutdown. The changes ensured supply deliveries and regular wage payments through spread of ownership, delegating more responsibilities to the Director and managers and introducing complex control mechanisms and state monitoring of the accounts and daily tasks. They appear relatively advance
III-V vertical nanowire MOSFETs (VNW-FETs) have the potential to extend Moore’s law owing to their excellent material properties. To integrate highly scaled memory cells coupled with high performance selectors at minimal memory cell area, it is attractive to integrate low-power resistive random access memory (RRAM) cells directly on to III-V VNW-FETs. In this work, we report the experimental demon
A green route for the production of 6-carbon polymer building blocks 6-hydroxyhexanoic acid, adipic acid and ϵ-caprolactone from 1,6-hexanediol, a hydrogenation product of biobased 5-hydroxymethylfurfural is reported. Gluconobacter oxydans oxidized 1,6-hexanediol completely to adipic acid, and selectively at pH 6-7 to 6-hydroxyhexanoic acid, which was converted to ϵ-caprolactone by catalytic cycli
Mobile communications have been undergoing a generational change every ten years or so. However, the time difference between the so-called "G's" is also decreasing. While fifth-generation (5G) systems are becoming a commercial reality, there is already significant interest in systems beyond 5G, which we refer to as the sixth-generation (6G) of wireless systems. In contrast to the already published
A highly standardized 99mTc-sulphur colloid was used to evaluate reticuloendothelial system (RES)-function in the normal rat and after RE blockade by gelatin (Haemaccel). Activity distribution in the animals was measured with a scintillation camera technique. Total uptake of activity in the liver was estimated. From the time-activity curves over the liver, the phagocytic index (kphag) was evaluate
Activated charcoal traps are used in nuclear medicine departments to capture exhaled radioactive xenon gas. In the present study, the trapping performance of charcoal was investigated for different physical qualities in experimental and clinical situations. Various factors affecting the trapping capacity are identified, such as the charcoal mass, moisture and carbon�dioxide concentrations in the
A low-cost microprocessor-based temperature controller for hyperthermia experiments on rats is described. The system directs a microwave generator, used for heating, by feedback power regulating signals in accordance with the temperature in the animal. The microwave power is pulsed for short on-and-off periods and the temperature recordings are carried out during the off periods. More than 300 hyp
A quantitative kinetic technique using a scintillation camera has been developed for investigating lymph drainage and the uptake in the lymph nodes of 99mTcSb2S3 colloid injected subcutaneously. Twenty-two patients with primary malignant melanoma were examined. Lymph-node dissection was performed and 185 lymph nodes were individually measured for radioactivity. The kinetics of colloid uptake in in
