The extent to which a favorable lifestyle may lower cancer risk in subjects with a family history of cancer is unknown. We conducted a prospective study in two Swedish cohorts, the Malmö Diet and Cancer Study (MDCS; n = 25,604) and the Malmö Preventive Project (MPP; n = 16,216). The association between a favorable lifestyle (based on nonsmoking, normal weight, absence of excessive drinking, regula

https://www.lupop.lu.se/article/lifestyle-and-cancer-incidence-and-mortality-risk-depending-family-history-cancer-two-prospective - 2025-08-23

The aim was to study the association between weight, mental health and experience of being bullied in 12‐year‐old children. Additional aim was to investigate the impact of childhood psychosocial risk factors for overweight and obesity at age 12. New publication in Acta Paediatrica

https://www.lupop.lu.se/article/mental-health-and-experience-being-bullied-12-year-old-children-overweight-and-obesity - 2025-08-23

ClinicalTrials.gov was established in 2000 in response to the Food and Drug Administration Modernization Act of 1997, which called for registration of trials of investigational new drugs for serious diseases. Subsequently, the scope of ClinicalTrials.gov expanded to all interventional studies, including diet trials. Presently, prospective trial registration is required by the National Institutes o

https://www.lupop.lu.se/article/discrepancies-registries-diet-vs-drug-trials - 2025-08-23

Applications are now accepted for the annual summer school of biostatistics and epidemiology. For more information and application form, go to http://www.biostatepi.org.

https://www.lupop.lu.se/article/summer-school-modern-methods-biostatistics-and-epidemiology - 2025-08-23

The introduction of new technology in joint replacement surgery requires close monitoring to identify early successes and failures. This monitoring can be effectively performed through the analysis of registry data and radiostereometric analysis studies. This study examined the revision rates of a contemporary knee system for total knee arthroplasty (TKA) using National Joint Replacement Registrie

https://www.lupop.lu.se/article/use-national-joint-registries-evaluate-new-knee-arthroplasty-design - 2025-08-23

We aimed to describe and evaluate the National Early Warning Score (NEWS) in the 24 hours preceding an in-hospital cardiac arrest among general somatic ward patients. The 24 hours preceding the in-hospital cardiac arrest were divided into four timespans and analysed by a medical record review of 127:254 matched case-control patients. The median NEWS ranged from 3 (2–6) to 6 (3–9) points for cases

https://www.lupop.lu.se/article/hospital-cardiac-arrest-and-preceding-national-early-warning-score-news-retrospective-case-control - 2025-08-23

Of patients with symptom onset in the 1980s, 1990s and 2000s, 35.0, 43.0 and 45.6% reached SR, respectively (P < 0.001 for each increment), and the odds of SR were higher in every decade compared with the one before. The hazard ratio for reaching SR was 1.15 (95% CI 1.14, 1.15) for each year from 1994 to 2009 compared with the year before. Five years after symptom onset in 2009, 45.3% of patients

https://www.lupop.lu.se/article/secular-trends-sustained-remission-rheumatoid-arthritis-nationwide-study-sweden - 2025-08-23

To review the highest impact studies published from the UK Biobank and assess their contributions to “precision medicine.” We reviewed 140 of 689 studies published between 2008 and May 2019 from the UK Biobank deemed to be high impact by citations, alternative metric data, or publication in a high impact journal. We classified studies according to whether they were largely methods papers, largely

https://www.lupop.lu.se/article/contributions-uk-biobank-high-impact-papers-era-precision-medicine - 2025-08-23

There is insufficient knowledge on how to avert neck/back pain from turning chronic or to impair work ability. The Swedish Government implemented a national multimodal rehabilitation (MMR) programme in primary care intending to promote work ability, reduce sick leave and increase return to work. Since randomised control trial data for effect is lacking, it is important to evaluate existing observa

https://www.lupop.lu.se/article/evaluation-multimodal-pain-rehabilitation-programme-primary-care-based-clinical-register-data - 2025-08-23

Within cancer care, dynamic evaluations of the loss in expectation of life provides useful information to patients as well as physicians. The loss of lifetime function yields the conditional loss in expectation of life given survival up to a specific time point. Due to the inevitable censoring in time-to-event data, loss of lifetime estimation requires extrapolation of both the patient and general

https://www.lupop.lu.se/article/estimating-loss-lifetime-function-using-flexible-parametric-relative-survival-models-0 - 2025-08-23

A film by Canadian Institutes of Health Research, Institute of Gender & Health See the film here.

https://www.lupop.lu.se/article/assessing-sex-and-gender-integration-peer-review - 2025-08-23

An important, yet infrequently discussed,point is that this conversion was derived for a Pearson correlation computed between a binary exposure X and a continuous outcome Y , also called a “point-biserial” correlation. New publication in Epidemiology

https://www.lupop.lu.se/article/simple-interpretable-conversion-pearsons-correlation-cohens-d-continuous-exposures - 2025-08-23

Causal mediation analysis is a topic of intense research. In this note, we derive an analytic expression for the proportion explained by mediation on the survival function scale, marginally over measured confounders. This expression has a simple form that does not depend on time, on the confounder distribution, or on the assumed models for the confounder effects on the mediator and on the outcome.

https://www.lupop.lu.se/article/approximate-expression-proportion-explained-mediation-survival-analysis - 2025-08-23

The key benefits of a scalable, automated data capture tool like GRHANITE™ cannot be fully realised in settings with under-developed electronic health infrastructure. While this approach remains promising for creating and maintaining a registry that monitors the quality of CR provided to patients, further investment is required in the digital platforms underpinning this approach. New publication i

https://www.lupop.lu.se/article/utilising-data-capture-tool-populate-cardiac-rehabilitation-registry-feasibility-study - 2025-08-23

Bias and confounding can distort findings from observational studies; adjustment or correction for these sources of error rarely dramatically change the results. Immortal time bias, which is included in the follow-up period during which the study outcome by design cannot occur, is a potential source of bias in longitudinal studies. Researchers often assume that immortal time bias has, if anything,

https://www.lupop.lu.se/article/example-how-immortal-time-bias-can-reverse-results-observational-study - 2025-08-23

The process of conducting and disseminating findings of epidemiologic investigations is not standardized. To address this, recommended guidelines, as opposed to mandated rules, were established over 4 decades ago that have become widely endorsed among the biomedical journals, including Epidemiology. One requirement in particular stipulates that the “[m]ethods section should aim to be sufficiently

https://www.lupop.lu.se/article/are-descriptions-methods-alone-sufficient-study-reproducibility-example-cardiovascular-literature - 2025-08-23

Standardization by a disease risk score (DRS) may be preferable to weighting on the exposure propensity score if the exposure is difficult to model, relatively novel (i.e., newly emerging or rapidly-evolving), or extremely rare. For exposures with more than two levels, methods are lacking for a DRS-based approach. We present an approach to estimate trends in standardized risk ratios (RRs) based on

https://www.lupop.lu.se/article/assessing-exposure-response-trends-using-disease-risk-score - 2025-08-23

The prevalence of CWP remained high over time, but with individual transitions between the pain groups. The development and persistence of CWP were predicted by more pain and worse health, with the addition of female gender and higher age for persistent CWP. Special attention and treatment alternatives for patients with SpA and concomitant CWP are essential in the clinic. New publication in Scandi

https://www.lupop.lu.se/article/risk-factors-development-and-persistence-chronic-widespread-pain-spondyloarthritis-population-based - 2025-08-23

Comorbidity indices calculated from electronic health records are commonly used in research studies for various reasons, including study inclusion criteria or to adjust for overall health status. However, changes in diagnosis codes and/or billing practices may alter index values and lead to inaccurate inclusions/exclusions or covariate adjustment. While extracting data for two retrospective cohort

https://www.lupop.lu.se/article/comorbidity-index-score-increases-due-coding-artifacts - 2025-08-23

LUNARC driver på uppdrag av Lunds universitet ett förstudieprojekt med syfte att undersöka behov av och möjligheter till tillgängliggörande och lagring över lång tid av universitetets forskningsdata. I samband med detta genomförs intervjuer med och observationsstudier av forskare, systemadministratörer och stödpersonal för att skapa ett bra underlag när processer och tekniska system för forsknings

https://www.lupop.lu.se/article/utredare-av-forskningsdatahantering - 2025-08-23