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Anxiety disorders are common in children and adolescents, but constrained resources limit access to cognitive-behavioral therapy (CBT). Stepped and stratified care models offer different ways to organize care. Stepped care starts with lower-resource CBT and escalates when needed, whereas stratified care matches CBT format to patient complexity from the outset. Economic evidence comparing these mod

In the Swedish universal healthcare system, persons living with rare diseases (PLWRD) face major challenges in receiving diagnosis and accessing care,stemming in part from heterogeneity of disease and systemic barriers to care. This contributes to health inequity and a lack of visibility for PLWRD within thehealth system. This Perspective paper provides an overview of the facilitators and challeng

Background: Patient expectations are important psychological determinants of health outcomes. The Treatment Expectation Questionnaire (TEX-Q) is a validated, multidimensional instrument for assessing treatment expectations; however, no Danish version has previously been available. This study aimed to translate and conduct an initial psychometric evaluation of a Danish version of the TEX-Q in patie

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in Type 1 Diabetes (T1D), but a subset of individuals remains free from macrovascular or renal complications despite decades of hyperglycaemia and a significant risk factor burden. We used a targeted proteomic approach (Olink Cardiovascular panel III, targeting 92 proteins) to characterize the proteomic profile of cardiov

Monitoring suspended sediment concentration (SSC) is essential for water-quality management and for anticipating sediment-related impacts. Yet sparse in situ measurements limit tracking SSC at high temporal and spatial resolution. We address this gap with a scalable approach that couples multispectral imagery (Landsat-8/9, Sentinel-2), remote sensing precipitation product (CHIRPS), and soil proper

Complement factor D (FD) (adipsin), is an adipokine essential for the activation of the complement alternative pathway (AP), contributing to inflammation but also to metabolic homeostasis through C3a production. We investigated the metabolic regulation of Cfd expression in mouse models. A diet-induced model of insulin resistance reduced expression of key AP components, including adipose Cfd, hepat

Urocanate reductase (UrdA) is a bacterial enzyme that converts urocanic acid to imidazole propionate. Its catalytic residue Arg411 undergoes a large conformational change in the substrate-bound versus product-bound states. In contrast to previously studied cryo-conditions, the room-temperature X-ray data of UrdA presented here show that the occupancy distribution of Arg411 is affected by crystal c

The issue of leaders’ influence has not received much attention in civil society studies, classical leadership literature on the voluntary sector and elite research. This article explores self-representations of the different kinds of status and influence among Italian third sector leaders. It is based on 35 interviews with the leaders of major Italian third sector organisations and on an analysis

Addressing sustainability challenges requires profound changes and transformations across all sectors, including tourism. Bound up in the operationalisation of transformation is the discursive aspects of change: the claims around how change can and should happen. This is a hitherto under-researched area, especially in sustainable tourism governance. This paper responds to this gap by investigating

Structural rearrangements have been shown to be important in local adaptation and speciation, but have been difficult to reliably identify and characterize in non-model species. Here we combine long reads, linked reads and optical mapping to characterize three divergent chromosome regions in the willow warbler Phylloscopus trochilus, of which two are associated with differences in migration and on

Proteins are useful chiral selectors. In order to understand the recognition mechanism and chiral discrimination, the binding of the (R)- and (S)-enantiomers of a series of designed amino alcohol inhibitors based on propranolol to cellobiohydrolase Cel7A (Trichoderma reesei) has been studied more closely. X-ray crystal structures were determined of the protein complex with the (R)- and (S)-enantio

Phase change heat storage is the backbone of energy storage technology, but its storage time is affected by the low thermal conductivity of phase change materials. Therefore, the melting performance of a triplex-tube latent heat thermal energy storage unit (T-LHTESU) in a phase change heat storage system is studied in this paper, and the rotation mechanism is applied to the unit. Firstly, a numeri

Importance: Chronic kidney disease (CKD) has been associated with increased plasma concentrations of phosphorylated tau (p-tau) 217 and p-tau181, which potentially decreases their usefulness in the diagnostic workup of Alzheimer disease (AD). Objective: To investigate associations of CKD with plasma ratios of p-tau217 and p-tau181 to the corresponding unphosphorylated peptides in AD. Design, Setti

This study is based on heat transfer and a two-dimensional MHD Walters’ liquid B flow containing copper nanoparticles driven by a stretching sheet in a porous medium. Mass transpiration and thermal radiation effects are considered. The set of partial differential equations affected by the Marangoni boundary condition is used. A nonlinear system of equations is solved to obtain the coupled ordinary

Image interpolation algorithms pervade many modern image processing and analysis applications. However, when their weighting schemes inefficiently generate very unrealistic estimates, they may negatively affect the performance of the end-user applications. Therefore, in this work, the author introduced four weighting schemes based on some geometric shapes for digital image interpolation operations

In this work, the best size for late gadolinium enhancement (LGE) magnetic resonance imaging (MRI) images in the training dataset was determined to optimize deep learning training outcomes. Non-extra pixel and extra pixel interpolation algorithms were used to determine the new size of the LGE-MRI images. A novel strategy was introduced to handle interpolation masks and remove extra class labels in

In recent years, the Inter-American Court of Human Rights (“IACrtHR”) has developed an innovative jurisprudence that has reaffirmed and further developed the right of indigenous peoples as an integrative part of the corpus juris of the international human rights law (“ihrl”). In fact, through a dynamic, systemic, evolutive and effective interpretation of the American Convention on Human Rights (“a

Background: Optimal reconstruction of the perineal defect after extended abdominoperineal excision remains uncertain, and randomized comparisons between biological mesh and myocutaneous flaps are lacking. This trial assessed whether an acellular porcine collagen implant (APCI) is non-inferior to a gluteus maximus myocutaneous flap (GMF) for pelvic floor reconstruction. Methods: NEAPE was a multice