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Volumetry of subregions in the medial temporal lobe (MTL) computed from automatic segmentation in MRI can track neurodegeneration in Alzheimer's disease. However, poor quality MR images can lead to unreliable segmentation of MTL subregions. Considering that different MRI contrast mechanisms and field strengths (jointly referred to as “modalities” here) offer distinct advantages in imaging differen

Background: Acute kidney injury (AKI) is a common complication of coronary artery bypass surgery (CABG) and is associated with worse outcomes. It remains unclear whether AKIs impact on prognosis can be attributed to other concurrent major complications. Methods: This retrospective cohort study included consecutive patients undergoing isolated CABG at a single nationwide center from 2001 to 2020. P

Fe-based metal amorphous nanocomposites, consisting of dispersed nanocrystallites within an amorphous metallic glass matrix, are used as low-loss soft-magnetic components in energy conversion devices. The nanocrystallites are formed by partial devitrification of the amorphous matrix and the properties of the composite are a result of the devitrification process. Understanding the rate-dependent cr

It is a well-established fact that the use of gestures is a ubiquitous feature of communication with language. This is true for both spoken and signed languages. However, while in spoken languages, gestures are produced in a different modality than speech (visual versus vocal/auditory, respectively), gestural elements in sign languages are produced in the same modality as sign (both are visual). T

This study investigates the interaction dynamics of directly injected (DI) hydrogen and methane jets with wall and neighboring jets in a non-reactive environment, focusing on the influence of wave-shaped piston geometry. Experiments were conducted in a high-pressure optical chamber using a custom 2-hole DI injector, with Schlieren imaging employed to capture the temporal evolution of jet structure

Laminin, a critical component of the basement membrane, plays an indispensable role in numerous biological processes. Among its subunits, laminin γ2 (LAMC2) emerges as a key player in the progression of cancer. This review delves into the current understanding of LAMC2′s role, highlighting its significant contribution to cancer development through promoting cell proliferation, invasion, and va

Multiple myeloma (MM) is a hematological disease of the plasma cell that remains clinically challenging despite the development of novel therapies. Epigenetic alterations have been demonstrated to contribute to MM pathogenesis, yet comprehensive studies into the links between different epigenetic regulatory systems in myeloma progression and drug resistance, though clinically relevant, are largely

Transcription factor cooperation is essential for specifying the heterogeneous dendritic cell (DC) lineages that orchestrate adaptive immunity, yet how it drives subset diversification remains poorly understood. Here, we employed a sequential anchored screen of 70 transcription factors using direct cellular reprogramming to identify regulators that specify type 2 conventional DCs (cDC2s) and plasm

The purple color of the barley (Hordeum vulgare L.) grain is attributed to anthocyanins which are beneficial for human health. Synthesis of these pigments in both grain and vegetative tissues is controlled by ANT1 and ANT2 that belong to the families R2R3-MYB and bHLH of transcription factors, respectively. Here, we investigated the role of the Ant2 gene in pigmentation of grains compared to veget

Objectives Assessment of Different NEoplasias in the adneXa (ADNEX) and Risk of Malignancy Index (RMI) are models that estimate the risk of malignancy in ovarian masses based on clinical and ultrasound information. The aim is to perform a meta-analysis of studies that compared the performance of the two models in the same patients (‘head-to-head comparison’). Design Systematic review and meta-anal

Bakgrund: Denna systematiska litteraturöversikt undersöker prevalensen av allergiska reaktioner mot propofol, med fokus på sambandet mellan födoämnesallergier och propofoladministrering. Propofol är ett vanligt använt anestesimedel för induktion och underhåll av anestesi. Även om det generellt anses vara säkert, har farhågor väckts angående potentiella anafylaktiska reaktioner, särskilt hos patien

Bakgrund: Ungdomar behöver i genomsnitt 8 - 10 timmars sömn per natt. Det har över tid skett en minskning av sömn hos ungdomar och forskning har visat att ungdomar idag upplever otillräcklig sömn. Sömn spelar en viktig roll gällande immunförsvar och kroppens återhämtningsförmåga och för lite sömn leder på lång sikt till koncentrationssvårigheter, irritabilitet och stress. Elevhälsa ska enligt Skol