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Head and neck postures may cause morphology changes to the geometry of the carotid bifurcation (CB) that alter the low and oscillating wall shear stress (WSS) regions previously reported as important in the development of atherosclerosis. Here the right and left CB were imaged by MRI in two healthy subjects in the neutral head posture with the subject in the supine position and in two other head p
Endovascular stents are widely used for the treatment of peripheral arterial disease (PAD). However, the development of in-stent restenosis and downstream PAD progression remain a challenge. Stent revascularisation of PAD causes arterial trauma and introduces abnormal haemodynamics, which initiate complicated biological processes detrimental to the arterial wall. The interaction between stent stru
With the increased availability of computational resources, the past decade has seen a rise in the use of computational fluid dynamics (CFD) for medical applications. There has been an increase in the application of CFD to attempt to predict the rupture of intracranial aneurysms, however, while many hemodynamic parameters can be obtained from these computations, to date, no consistent methodology
The geometric and hemodynamic characteristics of the left and right vertebral arteries (LVA, RVA) of six healthy volunteers were investigated for the supine (S) and the prone position (P) a common sleeping posture with head rotation. MRI images were used to reconstruct the subject specific three-dimensional solid models of the LVA and RVA from the level of the carotid bifurcation to the vertebroba
Stimulated by a recent controversy regarding pressure drops predicted in a giant aneurysm with a proximal stenosis, the present study sought to assess variability in the prediction of pressures and flow by a wide variety of research groups. In phase I, lumen geometry, flow rates, and fluid properties were specified, leaving each research group to choose their solver, discretization, and solution s
This paper aims at evaluating the changes that head rotation poses on morphological and flow characteristics of the carotid bifurcation (CB) and on the distribution of parameters that are regarded as important in atherosclerosis development, such as relative particle residence time (RRT), normalized oscillatory shear index (nOSI), and helicity (HL). Using a subject-specific approach, six healthy v
Atherosclerosis is the third leading cause of morbidity and mortality in the Western world. Low and oscillating wall shear stress (WSS) regions have been previously reported as parameters that correlate with the development of atherosclerosis. In this study we investigated geometric and hemodynamic changes in the carotid bifurcation as a result of posture change. Data from magnetic resonance imagi
An implementation of a small quantum absorption refrigerator in a circuit QED architecture is proposed. The setup consists of three harmonic oscillators coupled to a Josephson junction. The refrigerator is autonomous in the sense that it does not require any external control for cooling, but only thermal contact between the oscillators and heat baths at different temperatures. In addition, the set
Motivated by recent progress in electron quantum optics, we revisit the question of single-electron entanglement, specifically whether the state of a single electron in a superposition of two separate spatial modes should be considered entangled. We first discuss a gedanken experiment with single-electron sources and detectors, and demonstrate deterministic (i. e. without post-selection) Bell ineq
The Keldysh-ordered full counting statistics is a quasiprobability distribution describing the fluctuations of a time-integrated quantum observable. While it is well known that this distribution can fail to be positive, the interpretation and origin of this negativity has been somewhat unclear. Here, we show how the full counting statistics can be tied to trajectories through Hilbert space, and ho
We evaluate the distribution of waiting times between electrons emitted by a driven mesoscopic capacitor. Based on a wave packet approach we obtain analytic expressions for the electronic waiting time distribution and the joint distribution of subsequent waiting times. These semi-classical results are compared to a full quantum treatment based on Floquet scattering theory and good agreement is fou
We evaluate the joint distributions of electron waiting times in coherent conductors described by scattering theory. Successive electron waiting times in a single-channel conductor are found to be correlated due to the fermionic statistics encoded in the many-body state. Our formalism allows us also to investigate the waiting times between charge transfer events in different outgoing channels. As
We theoretically investigate the thermoelectric properties of heat engines based on Mach-Zehnder interferometers. The energy dependence of the transmission amplitudes in such setups arises from a difference in the interferometer arm lengths. Any thermoelectric response is thus of purely quantum-mechanical origin. In addition to an experimentally established three-terminal setup, we also consider a
We propose and analyze a simple mesoscopic quantum heat engine that exhibits both high power and high efficiency. The system consists of a biased Josephson junction coupled to two microwave cavities, with each cavity coupled to a thermal bath. Resonant Cooper pair tunneling occurs with the exchange of photons between cavities, and a temperature difference between the baths can naturally lead to a
We investigate theoretically a Mach-Zehnder interferometer driven by a time-dependent voltage. Motivated by recent experiments, we focus on a train of Lorentzian voltage pulses which we compare to a sinusoidal and a constant voltage. We discuss the visibilities of Aharonov-Bohm oscillations in the current and in the noise. For the current, we find a strikingly different behavior in the driven as c
