We analyzed the structural and material properties of small interfering RNA (siRNA)-loaded lipid-polymer hybrid nanoparticles (LPNs) containing ionizable lipidoid and poly(dl-lactic-co-glycolic acid) (PLGA) using small-angle X-ray scattering, cryogenic transmission electron microscopy, polarized light microscopy, the Langmuir monolayer methodology, differential scanning calorimetry, and attenuated

Too dangerous to forget – a semiotic and contextual study of the memorial Romanoparken – Sång om en plats This essay examines the memorial Romanoparken – Sång om en plats (2020), which embodies Roma memories. However, there are risks with memorials when they take the material form of a monument that they are seen as completed actions and the completion can lead to distancing oneself from the

In any country, land ownership and land records management are prime objectives of any land record management authority. These issues are of key importance in Pakistan for land individuals as well as for land record management authorities. Currently, land records and revenue maps are maintained by the land revenue officers manually and are available in outdated form. The Land revenue maps are made

Landscapes fill a fundamental function of the human experience. The variance of these landscapes however, are vast, and arguably, so could the human experience of them and the ways they are expressed linguistically be as well. Of the few studies that so far has been conducted on this, none has focused on North America as a whole in a quantitative manner. This study aims to explore what systems lan

To address the challenges of an ageing population, it is important to promote health by identifying factors for healthy ageing. The aim of this study was to investigate the bidirectional association between physical activity (PA) and sleep in healthy Japanese super-seniors over the age of 80. For approximately 1 year, 124 participants wore wearable devices and answered daily lifestyle questionnair

With regards to research animal models related to immune thrombocytopenia (ITP), there is an extensive literature of over 300 publications published since 1959. It appears that many of these models either confirm what has been found in human ITP or, in some instances, are the first to describe a phenomenon related to ITP that is still of relevance today in human medicine. These models will undoubt

While much has been learned about the basic immunology and clinical characteristics of immune thrombocytopenia, many important questions remain with regard to pathogenesis, disease progression, identification of novel therapeutic targets and approaches, and clinical trials that rationalize and optimize use of existing therapies. The answers to these questions are likely to impact our understanding

Syfte: Att belysa unga vuxnas upplevda kunskap om sexuell hälsa samt om deras syn på sexuell hälsa har påverkats av samhällets åtgärder som sexualundervisning i skolan, samtyckeslagen och #Metoo. Metod: Kvantitativ ansats med tvärsnittsdesign där data har samlats in med hjälp av en enkätundersökning som publicerades på Facebook. Resultat: Av respondenterna var 67% kvinnor och 33% män. Den informa

ObjectivesShort time to positivity (TTP) has been proposed as a prognostic indicator in bloodstream infection (BSI) but results have been conflicting. The aim of this study was to explore the association between TTP and disease severity, using non-linear models.MethodsThis population-based retrospective study included all blood cultures in southern Sweden, from 2021 through 2023. Using healthcare

A range of neuroradiological findings has been reported in patients with COVID-19, some mimicking cerebral small vessel disease (CSVD). We present a case of a man in his 50s with severe COVID-19, who was Glasgow Coma Scale 3 and tetraparetic after sedation was ceased in the intensive care unit. Return of consciousness and motor activity was slow. An MRI 1 month after debut of symptoms demonstrated

Introduction: Some children may witness their grandparents or great-grandparents spending their final days in a nursing home, while others have peers with older relatives living in nursing homes. Children learn about ageing through experience and exposure, where picture books can also shape their perceptions and attitudes toward older adults residing in nursing homes.Aim: To explore the underlying

Objective Half of all adult emergency department (ED) visits with a complaint of dyspnea involve acute heart failure (AHF), exacerbation of chronic obstructive pulmonary disease (eCOPD), or pneumonia, which are often misdiagnosed. We aimed to create an artificial intelligence (AI) diagnostic decision support tool to detect patients with AHF, eCOPD, and pneumonia among dyspneic adults at the beginn

IMPORTANCE: Recent studies suggest standard reference intervals for serum free light chains (FLC) are inaccurate and that this problem can only be partially remedied by using separate reference intervals for individuals with impaired kidney function. This decreases the utility of FLC testing in the clinical evaluation and follow-up of plasma cell disorders, particularly affecting the diagnosis of

Background: High-grade glioma (HGG) of the spinal cord constitutes rare tumors in the pediatric population. Knowledge of the molecular profile of this pediatric HGG (pedHGG) subgroup is limited and the clinical outcome is poor. Therefore, the aim of this study is to provide more profound investigations of molecular characteristics and clinical features of these tumors. Methods: Between January 201

Background: The application of international recommendations for paediatric maintenance haemodialysis (HD) could be strengthened by national laws or written recommendations. Our aim was therefore to describe the national rules governing paediatric maintenance HD in European countries. Methods: A national representative, approved by the president of each paediatric nephrology society, was contacted

Electrons photoemitted by extreme ultraviolet attosecond pulses derive spatially from the first few atomic surface layers and energetically from the valence band and highest atomic orbitals. As a result, it is possible to probe the emission dynamics from a narrow 2D region in the presence of optical fields, as well as obtain elemental specific information. However, combining this with spatially-re

Background: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are increasingly used in patients with type 2 diabetes, chronic kidney disease, and heart failure. However, their safety and efficacy in patients with congenital or surgically altered urogenital anatomy remains underexplored. Methods: We conducted a narrative review of current evidence regarding the use of SGLT2i in patients with urina

Polarized fluorescence microscopy is a valuable tool for measuring molecular orientations in biological samples, but techniques for recovering three-dimensional orientations and positions of fluorescent ensembles are limited. We report a polarized dual-view light-sheet system for determining the diffraction-limited three-dimensional distribution of the orientations and positions of ensembles of fl

Predictors for the pharmacological effect of ADHD medication in children and adolescents are lacking. This study examined clinically relevant factors in a large (N = 638) prospective cohort reflecting real-world evidence. Children and adolescents aged 6–17 diagnosed with ADHD were evaluated at baseline and three months following ADHD medication initiation. The outcome was measured as a reduction i