Brain pericytes are important to maintain vascular integrity of the neurovascular unit under both physiological and ischemic conditions. Ischemic stroke is known to induce an inflammatory and hypoxic response due to the lack of oxygen and glucose in the brain tissue. How this early response to ischemia is molecularly regulated in pericytes is largely unknown and may be of importance for future the

One of the challenges of establishing an industrially competitive process to ferment lignocellulose to value-added products using Saccharomyces cerevisiae is to get efficient mixed sugar fermentations. Despite successful metabolic engineering strategies, the xylose assimilation rates of recombinant S. cerevisiae remain significantly lower than for the preferred carbon source, glucose. Previously, One of the challenges of establishing an industrially competitive process to ferment lignocellulose to value-added products using Saccharomyces cerevisiae is to get efficient mixed sugar fermentations. Despite successful metabolic engineering strategies, the xylose assimilation rates of recombinant S. cerevisiae remain significantly lower than for the preferred carbon source, glucose. Previously,

Ashbya gossypii is a homothallic, flavinogenic, filamentous ascomycete that starts overproduction of riboflavin and fragments its mycelium quantitatively into spore producing sporangia at the end of a growth phase. Mating is not required for sporulation and the standard homothallic laboratory strain is a MATa strain. Here we show that ectopic expression of Saccharomyces cerevisiae MATα2 in A. gossAshbya gossypii is a homothallic, flavinogenic, filamentous ascomycete that starts overproduction of riboflavin and fragments its mycelium quantitatively into spore producing sporangia at the end of a growth phase. Mating is not required for sporulation and the standard homothallic laboratory strain is a MATa strain. Here we show that ectopic expression of Saccharomyces cerevisiae MATα2 in A. goss

In this research, it is shown that robot joint torques can be used to recognize contact force transients induced during robotic manipulation, thus detecting when a task is completed. The approach does not assume any external sensor, which is a benefit compared to the state of the art. The joint torque data are used as input to a recurrent neural network (RNN), and the output of the RNN indicates w

In this paper, it is shown that temporally coupled dynamical movement primitives (DMPs), used to model and execute robot movements, are globally exponentially stable. It follows that DMPs converge to their goal configurations, which is necessary to accomplish most tasks. The convergence is proven mathematically, and then verified in simulations as well as experimentally on an industrial robot.

AIMS AND OBJECTIVES: To investigate the cancer rehabilitation experiences of working-age cancer survivors.BACKGROUND: Cancer survivors have extremely complex needs, spanning physical, vocational, and sexual domains. Although cancer rehabilitation services have been found to eliminate or reduce these strains, these services are often underutilized.DESIGN: A cross-sectional study design was employed

Mikrober finns överallt, runt omkring oss i vår miljö och inuti våra kroppar. De som lever tillsammans med djur har mycket stor påverkan på värdens hälsa och evolutionära fitness. Från ett djurs perspektiv är vissa mikrober goda, andra onda, och vissa har ingen större påverkan på hälsan, men egentligen beror dessa egenskaper på sammanhanget, eftersom det är vanligt att mikrober byter strategi tillThe microbes living inside hosts have highly important consequences for host health and fitness. From the host’s perspective, some microbes exhibit mutualistic tendencies, others parasitic, and some commensal, but this is context-dependent and opportunistic lifestyles are widespread in nature. Our knowledge of how hosts interact molecularly with different microbes is, however, poor, and little res

Given the substantial impacts that are expected due to climate change, it is crucial that accurate rainfall–runoff results are provided for various decision-making purposes. However, these modeling results often generate uncertainty or bias due to the imperfect character of individual models. In this paper, a genetic algorithm together with a Bayesian model averaging method are employed to provide

I valrörelsen 2018 väntas sociala medier spela en stor roll, särskilt för ungdomar, eftersom sociala medier utgör deras främsta plattform för nyhetskonsumtion och kommunikation. Denna kvalitativa intervju- och fokusgruppstudie undersöker 110 svenska ungdomars inställning till politiskt deltagande i sociala medier. Med hjälp av ett explorativt anslag som inkluderar politiskt mycket aktiva såväl som

Artikeln redogör för det förslag till modellregler för EU:s förvaltningsrätt som har utarbetats inom det europeiska forskningsnätverket ReNEUAL (Research Network on EU Administrative Law) och vad förslaget principiellt kan innebära för förvaltningsrätten i Sverige och övriga nordiska länder. Särskilt undersöks vilken betydelse nordisk förvaltningsrätt har haft för modellreglerna, förutsättningarna

Retail and place have always been in a dynamic interrelation throughout the history. However particularly in the last three decadesthere have been some radical shifts in the outcomes of this interrelationship. The spatial formation of stores, shopping streets,malls, and in turn, cities have dramatically changed. These contemporary shifts, formations and transformations in the retailgeographies hav

I efterdyningarna av finanskrisen 2008 konstaterade man bl.a. att det var ett problem att viktiga aktörer arbetade med allt för litet eget kapital, vilket gjorde dem riskbenägna. Med litet eget kapital skjuts risk i ett AB över från aktieägare till långivare. Inom bolaget finns liknande problem mellan en avdelning och bolaget och mellan anställd och bolaget. Det är helt enkelt attraktivt att ta ri

This paper provides regional GDP estimates for the 24 Swedish regions (NUTS-3) for the benchmark year 1571 and for 11 ten-year benchmarks for the period 1750–1850. The 1571 estimates are based on tax sources and agricultural statistics. The 1750–1850 estimates are produced following the widely used methodology by Geary and Stark (2002): labour force figures from population censuses at regional lev

Underavsnitt:1) Efter Sovjetunionens upplösning2) 1990-talets ekonomiska kris3) Ryska stormaktsambitioner4) Militära konflikter och utrikespolitik5) Inskränkningar i mänskliga rättigheterUnderavsnitt:1) Efter Sovjetunionens upplösning2) 1990-talets ekonomiska kris3) Ryska stormaktsambitioner4) Militära konflikter och utrikespolitik5) Inskränkningar i mänskliga rättigheter