Glycosaminoglycans (GAGs) such as heparin and heparan sulfate (HS) play crucial roles in inflammation and wound healing, serving as regulators of growth factors and pro-inflammatory mediators. In this study, we investigated the influence of heparin/HS on thrombin proteolysis and its interaction with the generated 11 kDa thrombin-derived C-terminal peptides (TCPs). Employing various biochemical and

Aims. We aim to determine the influence of the Milky Way's warp on the kinematics of stars across the disc, and therefore measure its precession rate and line of nodes under different assumptions. Methods. We applied Jeans'first equation to a model of a rigidly precessing warp. The predictions of these models were fitted to the average vertical velocities of stars with measured line-of-sight veloc

We introduce a model of hadronization based on invertible neural networks that faithfully reproduces a simplified version of the Lund string model for meson hadronization. Additionally, we introduce a new training method for normalizing flows, termed MAGIC, that improves the agreement between simulated and experimental distributions of high-level (macroscopic) observables by adjusting single-emiss

We study a simple extension of the Standard Model featuring a dark sector with an ultralight pseudo-Nambu-Goldstone boson as a dark matter candidate. We focus on the mass range O(10-20-10-10) eV, relevant for strong gravity applications, and explore its production and evolution in the early Universe. The model is formulated in such a way that dark matter does not couple directly to photons or othe

Heterotopic ossification (HO) in tendons can lead to increased pain and poor tendon function. Although it is believed to share some characteristics with bone, the structural and elemental compositions of HO deposits have not been fully elucidated. This study utilizes a multimodal and multiscale approach for structural and elemental characterization of HO deposits in healing rat Achilles tendons at

BACKGROUND: Tuberous sclerosis complex (TSC) is a rare multisystem autosomal dominant disorder caused by pathogenic variants in either the TSC1 or TSC2 gene. Common manifestations of TSC have been grouped into major and minor clinical diagnostic criteria and assessed in clinical routine workup. However, case studies point towards the existence of rare disease manifestations and to the potential as

Recently, acqui-hiring, which refers to the acquisitions driven by gaining access to target human capital, has emerged as a proliferating phenomenon in acquisitions of small technology firms. However, we still know little about this phenomenon, particularly outside the community of Silicon Valley. This study sheds new light on the nature of acqui-hiring by focusing on what drives acqui-hiring. Usi

This publication charts the history of the groundbreaking textile design portfolio created by the Argentine collective Buen Diseño para la Industria—formed by geometric abstract artists José Antonio Fernández-Muro, Sarah Grilo, Alfredo Hlito, and Miguel Ocampo—and locates it at the utopic intersection of modernist visual practice and industrial design.The book’s centerpiece is a stunning set of re

An Exhibition History of Latin American Art compiles texts by twenty-one Latin American curators who were asked to select an exhibition that took place in Latin America or focused on the work of Latin American artists and justify its importance, relevance, and influence. The history of Latin American art exhibitions that is thus constructed considers the array of social and institutional contexts

Translated PhD dissertation into Spanish.From the editors: ¿Es el arrepentimiento una forma de memoria?, ¿una manera de narrarnos a nosotros mismos?, ¿un acto de imaginación? Alejandro Cesarco ha desarrollado una práctica artística heterodoxa a partir de recursos como la repetición, la narratividad, la lectura o la traducción. Con este libro, en el que cuestiona un devenir del arte regido por el p

The literature on the prevalence and causes of punishment has been dominated by research into the United States. Yet most of the world's prisoners live elsewhere, and the United States is no longer the country with the world's highest incarceration rate. This article considers what we know about the prevalence and causes of incarceration around the world. We focus on three features of incarceratio

We present a synchronized multisensory dataset for accurate and robust indoor localization: the Lund University Vision, Radio, and Audio (LuViRA) Dataset. The dataset includes color images, corresponding depth maps, inertial measurement unit (IMU) readings, channel response between a 5G massive multiple-input and multiple-output (MIMO) testbed and user equipment, audio recorded by 12 microphones,

Changes in the extracellular matrix of pulmonary arteries (PAs) are a key aspect of vascular remodeling in pulmonary hypertension (PH). Yet, our understanding of the alterations affecting the proteoglycan (PG) family remains limited. We sought to investigate the expression and spatial distribution of major vascular PGs in PAs from healthy individuals and various PH groups (chronic obstructive pulm

In the framework of the RECCAP2 initiative, we present the greenhouse gas (GHG) and carbon (C) budget of Europe. For the decade of the 2010s, we present a bottom-up (BU) estimate of GHG net-emissions of 3.9 Pg CO2-eq. yr−1 (using a global warming potential on a 100 years horizon), which are largely dominated by fossil fuel emissions. In this decade, terrestrial ecosystems acted as a net GHG sink o

This report is a synthesis analysis to a project that has been carried out within the collaborative research program Renewable transportation fuels and systems (Förnybara drivmedel och system), Project no. 40771-1, Environmental and Socio-Economic Benefits from Swedish Biofuel Produc- tion. The project has been financed by the Swedish Energy Agency and f3 – Swedish Knowledge Centre for Renewable T

Background: Identifying factors associated with vaccine uptake among health care workers (HCWs) remains crucial to generating evidence aimed at guiding national COVID-19 vaccination and future infectious disease outbreak strategies. This study aimed to elucidate these factors, focusing on the interplay between socio-demographic, health, knowledge, beliefs and attitudinal indicators. Methods: This

Purpose:To study the incidence, predictive factors, etiology, and visual consequences of postoperative endophthalmitis (PE) in relation to 3 intracameral (IC) antibiotic regimes.Setting:Swedish National Cataract Register entries from 2011 through 2017.Design:Observational retrospective study.Methods:PE incidence, influencing factors, bacteriology, and visual outcome were analyzed regarding the 3 m

We study pair correlation functions for planar Coulomb systems in the pushed phase, near a ring-shaped impenetrable wall. We assume coupling constant Γ=2 and that the number n of particles is large. We find that the correlation functions decay slowly along the edges of the wall, in a narrow interface stretching a distance of order 1/n from the hard edge. At distances much larger than 1/n, the effe

Histidine is a key amino-acid residue in proteins with unique properties engendered by its imidazole side chain that can exist in three different states: two different neutral tautomeric forms and a protonated, positively charged one with a pKa value close to physiological pH. Commonly, two or all three states coexist and interchange rapidly, enabling histidine to act as both donor and acceptor of

It is generally known that, unlike structured proteins, intrinsically disordered proteins, IDPs, exhibit various structures and conformers, the so-called conformational ensemble, CoE. This study aims to better understand the conformers that make up the IDP ensemble by decomposing the CoE into groups separated by their radius of gyration, Rg. A common approach to studying CoE for IDPs is to use low