Radiobiological optimization including consideration of secondary cancer risk A treatment modality comparison study for pediatric medulloblastoma
Purpose: To estimate and compare normal tissue toxicity and secondary cancer (SC) risks from 3D conformal radiotherapy (3D CRT), arc radiotherapy (ART) and intensity modulated proton therapy (IMPT) for treatment of pediatric medulloblastoma (MB). The purpose was also to investigate the possibility of optimizing radiotherapy treatment with the aim of reducing normal tissue toxicity as well as the r