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Socratic Provocation in Art

In his ‘Provocation in Philosophy and Art’ Dan Egonsson argues that provocation is integral to Socrates’ way of doing philosophy both when aiming for (the interlocutor’s) personal moral development and as an instrument for societal change, and that provocation in art differs significantly from its Socratic counterpart. Morally dubious provocation in art can, however, Egonsson argues be justified o

Subclass-switched anti-Spike IgG3 oligoclonal cocktails strongly enhance Fc-mediated opsonization

Antibodies play a central role in the immune defense against SARS-CoV-2. Emerging evidence has shown that nonneutralizing antibodies are important for immune defense through Fc-mediated effector functions. Antibody subclass is known to affect downstream Fc function. However, whether the antibody subclass plays a role in anti-SARS-CoV-2 immunity remains unclear. Here, we subclass-switched eight hum

Haemophilia B - Diagnostic Insights, Genetic Aspects and Clinical Outcomes

Haemophilia B (HB) is a rare inherited bleeding disorder caused by the deficiency of coagulation factor IX (FIX). The major clinical issues are bleedings, often targeting the joints, and the development of neutralising antibodies, i.e. inhibitors, to the FIX replacement therapy. Historically HB has been seen as identical to the more common haemophilia A (HA), i.e. deficiency of coagulation factor