AIMS/HYPOTHESIS: Insulin secretion in pancreatic islets is dependent upon mitochondrial function and production of ATP. The transcriptional coactivator peroxisome proliferator activated receptor gamma coactivator-1 alpha (protein PGC-1alpha; gene PPARGC1A) is a master regulator of mitochondrial genes and its expression is decreased and related to impaired oxidative phosphorylation in muscle from p

The purpose of this study was to test the hypothesis that glutamate cysteine ligase catalytic subunit (GCLC) promoter polymorphisms are susceptibility factors for type 1 diabetes (T1D), T1D age-at-onset and T1D autoantibodies. T1D patients and control subjects from the Swedish Childhood Diabetes Registry and the Swedish Diabetes Incidence Study registry were genotyped for two GCLC promoter polymor

A novel adaptive friction compensator based on a dynamic model recently proposed in the literature is presented in this paper. The compensator ensures global position tracking when applied to an n degree of freedom robot manipulator perturbed by friction forces with only measurements of position and velocity, and all the system parameters (robot and friction model) unknown. Instrumental for the so

An installation for testing techniques related to seeding and harmonic generation has been completed at MAXlab. The aim is to study the processes around seeded harmonic generation at 130/88/54 nm, the 2/3/5 harmonic of a Ti: Sapphire laser. During the spring 2008 the commissioning work has begun and this paper will report on the progress. The test FEL is built around the existing linac injector at

This paper describes an 8-Bit, 100-MHz current steering CMOS low glitch interpolation digital to analog converter (DAC). It includes a 16-tap voltage controlled delay line and 8-Bit based linear interpolators, making the effective clock rate up to 1.6-GHz. With the linear interpolation, the requirement on the analog reconstruction filter is relaxed, and low glitch digital to analog conversion is a

An 18th (4th+14th) order gm -C IF filter for the Bluetooth short-range radio, implemented in a 0.6 μm CMOS process, is presented. The filter bandwidth is 1 MHz, the center frequency fc is 3 MHz, the in-band group delay variation is 0.75 μs, and the stop-band attenuation at fc±1 MHz is at least 47 dB. The noise floor is 250 μVr.m.s. and the spurious free dynamic range is at least 58 dB for out-of-b

Ministerial portfolios are the most obvious payoffs for parties entering a governing coalition in parliamentary democracies. This renders the bargaining over portfolios an important phase of the government formation process. The question of ‘who gets what, and why?’ in terms of ministerial remits has not yet received much attention by coalition or party scholars. This article focuses on this quali

This article addresses the relation between the design of regulatory agencies and efficiency, arguing that authority concentrated to a single individual outperforms more collegial decision-making when the regulated firms’ interests are aligned. The tentative explanation is that concentrated leadership reduces the risk for capture. This argument is developed from an empirical case on the markets fo

BACKGROUND AND OBJECTIVES: While alcohol consumption is associated with common risk factors for diastolic dysfunction the independent impact of low levels of alcohol consumption on this condition in a community setting is still unclear.Thus, the aim of this study was to explore this association in a representative population sample employing optimal echocardiographic techniques.DESIGN: Cross-secti

Aims: Deep neural network artificial intelligence (DNN-AI)-based Heart Age estimations have been presented and used to show that the difference between an electrocardiogram (ECG)-estimated Heart Age and chronological age is associated with prognosis. An accurate ECG Heart Age, without DNNs, has been developed using explainable advanced ECG (A-ECG) methods. We aimed to evaluate the prognostic value

Objective: The purpose of this study was to determine whether alcohol use disorder (AUD) can be transmitted contagiously in siblings and likely acquaintances growing up close to one another (Propinquity-of-Rearing Defined Acquaintances [PRDAs]). Method: PRDAs were pairs of same-age subjects growing up within 1 km of each other and sharing the same school class, where one of whom (PRDA1) was first

Of concern is the fractional Kadomtsev–Petviashvili (fKP) equation and its lump solution. As in the classical Kadomtsev–Petviashvili equation, the fKP equation comes in two versions: fKP-I (strong surface tension case) and fKP-II (weak surface tension case). We prove the existence of nontrivial lump solutions for the fKP-I equation in the energy subcritical case α>45 by means of variational method

Background: Lateral wedge insoles (LWIs) are non-surgical interventions used in medial knee osteoarthritis (KOA) aiming at restoring correct joint biomechanics. However, the mechanical efficacy of LWIs, based on modulation of the external knee adduction moment, is partially proved and high variability in response to these devices was observed. Research question: The principal aim of the study was

Background and purpose — Knee extensor (KE) muscle weakness is a modifiable feature commonly observed in individuals with knee osteoarthritis (KOA) and constitutes a potential target for patient-specific interventions. Therefore, in this study, we explored whether KE weakness is associated with radiographic (medial and/or lateral) KOA progression and how this relationship differs depending on fron

Objective: To describe the use of non-steroidal anti-inflammatory drugs (NSAID), opioids, and physiotherapy (PT) among persons with newly diagnosed knee or hip osteoarthritis (OA) with and without NSAID contraindications or precautions. Design: We used population-based register data to identify adults aged ≥35 as of January 1, 2014, residing in Skåne region (Sweden) between 2004 and 2013, without