Background: Whether long-term effectiveness differs between anti-tumour necrosis factor (anti-TNF) agents is unknown. Aims: To examine drug survival of first-line anti-TNF agents and identify predictors of discontinuation. To reduce channelling bias, we also compared drug survival of the second anti-TNF. Methods: Biologic-naïve patients (N = 955) recorded in the Swedish IBD Quality Register (SWIBR

Deep learning (DL) is the state-of-the-art methodology in various medical image segmentation tasks. However, it requires relatively large amounts of manually labeled training data, which may be infeasible to generate in some applications. In addition, DL methods have relatively poor generalizability to out-of-sample data. Multi-atlas segmentation (MAS), on the other hand, has promising performance

This paper examines virtual manifestations of “sad girls” on the media platform Tumblr. Here users write about their struggles with mental illness, revealing a set of shared experiences that encompass both psyche and body. Predominant narratives of what it means to be mentally ill are questioned, and alternative conceptualizations of the psyche are introduced. I argue that the sad girls legitimize

This thesis examines the reaction of political institutions to the structural transformation of the British economy from 1700 to 1850. The majority of the literature on the relationship between institutions and economic growth conceptualises the political institutions as a precondition to modern economic growth in the British context. Getting its inspiration from Lennart Schön’s theoretical framew

Review article on anthropology of NGO research with point of departure on two ethnographic monographs on NGOs and civil society development in Serbia, with proposals for further NGO research.

A new method for estimation of intragranular strain fields in polycrystalline materials based on scanning three-dimensional X-ray diffraction (scanning 3DXRD) data is presented and evaluated. Given an a priori known anisotropic compliance, the regression method enforces the balance of linear and angular momentum in the linear elastic strain field reconstruction. By using a Gaussian process (GP), t

When the television show Girls premiered in 2012 it reverberated far and wide in the media landscape of the Global North. It was equally celebrated for its body positive message and critiqued for its whiteness and privileged blindspots. The show's creator and star, Lena Dunham, became an essential part of its paratext, her persona as hotly contested as the show itself. Often compared to the “ur-po

This entry reviews the ways in which “traditional” intimacy concerning sex and relationships have been transformed by communication technologies, as well as how these technologies have made a range of other connections “intimate.” It does so by discussing three different kinds of mediated intimacy as it is expressed in the Global North. The first meaning refers to work on the way in which discoursThis entry reviews the ways in which “traditional” intimacy concerning sex and relationships have been transformed by communication technologies, as well as how these technologies have made a range of other connections “intimate.” It does so by discussing three different kinds of mediated intimacy as it is expressed in the Global North. The first meaning refers to work on the way in which discours

Femoroacetabular impingement (FAI) syndrome is often treated with hip arthroscopy (HA) with the goal of enabling return to sport. While the number of HAs has been rising, little is known about the rehabilitation process or about outcomes related to return to sport (RTS) following the procedure. The overarching aim of this thesis wasto describe the rehabilitation process following HA in Scandinavia

Understanding the dissolution mechanism of deuterated bacterial cellulose (DBC) is important to engineer advanced material applications such as in quantifying and visualizing biomolecules at the cellulose interface for diagnostics. Small-angle neutron scattering (SANS) is applied to evaluate the distribution and volume fraction of dissolved DBC chains in 1-ethyl-3-methylimidazolium acetate (EMIM-A

ApoE is a well-known lipid-binding protein that plays a main role in the metabolism and transport of lipids. More recently, apoE-derived peptides have been shown to exert antimicrobial effects. Here, we investigated the antibacterial activity of apoE using in vitro assays, advanced imaging techniques, and in vivo mouse models. The formation of macromolecular complexes of apoE and endotoxins from G

Objective: Interdisciplinary pain rehabilitation (IPR) usually employs a cognitive–behavioural therapeutic (CBT) approach. However, there is growing support for chronic pain treatments based on acceptance and commitment therapy (ACT). Most studies of ACT and CBT for chronic pain have evaluated their effects after psychological interventions, not after IPR. We compared the results of an ACT-based I

Obstructive Sleep Apnea (OSA) is one of the main under-diagnosed sleep disorder. It is an aggravating factor for several serious cardiovascular diseases, including stroke. There is, however, a lack of medical devices for long-term ambulatory monitoring of OSA since current systems are rather bulky, expensive, intrusive, and cannot be used for long-term monitoring in ambulatory settings. In this pa

Ethernet AVB is being actively considered by the automotive industry as a candidate for in-vehicle communication backbone. However, several questions pertaining to schedulability of hard real-time messages transmitted via such a switch remain unanswered. In this paper, we attempt to fill this void. We derive equations to perform worst-case response time analysis on Ethernet AVB switches by conside

Today, epilepsy is one of the most common chronic diseases affecting more than 65 million people worldwide and is ranked number four after migraine, Alzheimer's disease, and stroke. Despite the recent advances in anti-epileptic drugs, one-third of the epileptic patients continue to have seizures. More importantly, epilepsy-related causes of death account for 40% of mortality in high-risk patients.

In this essay, we explore what happens when science meets comic art and how such meeting offers an opportunity to rethink science communication. We base our discussion on our own experience, as research scholars, of engaging in a collaboration with a comic artist. Three key reflections are developed: how comic art may help to (1) conceptualize ideas in an early research phase, (2) clarify the main

Background and Purpose: Clinicians will increasingly encounter adult patients who were born preterm and will need to understand their long-term sequelae. Adult survivors of preterm birth have been reported to have increased risks of hypertension and other stroke risk factors. However, their stroke risks have seldom been examined and the findings are discrepant, possibly due to small sample sizes,

Safety Performance Functions and Crash Modification Factors are statistically-based prediction methods that require significant efforts and long periods in crash data collection. Traffic conflict studies can mitigate this issue using a short time survey to measure the number and severity of traffic conflicts, which are regarded as surrogate safety measures. Unfortunately, they are empirical studie

Monitoring of individual biomarkers has the potential of explaining the hazard of survival outcomes. In practice, these measurements are intermittently observed and are known to be subject to substantial measurement error. Joint modelling of longitudinal and survival data enables us to associate intermittently measured error-prone biomarkers with risks of survival outcomes and thus plays an import