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Diabetes is a growing global problem, with hundreds of millions of people living with the disease worldwide. Diabetes can be divided into two major subtypes, autoimmune type 1 diabetes (T1D), and type 2 diabetes (T2D), which has stronger causal links in obesity, lifestyle, and age. Although immunity and inflammation are clearly defined in T1D, it is also understood that inflammation has a role in
The perivascular space (PVS) is integral to glymphatic function, facilitating fluid exchange and waste clearance in the brain. Diffusion tensor imaging along the perivascular space (DTI-ALPS) has been proposed as a noninvasive marker of perivascular diffusion, yet its specificity remains unclear. ALPS measures assume radial symmetry in white matter (characterized by equal transverse diffusion eige
Gut microbial communities can facilitate traits that are essential for invasive species survival in novel environments. Despite the global plethora of invasive social insect species, the role of the gut microbiome in colonisation success under novel dietary and environmental conditions is little known. The introduction of the European buff-tailed bumblebee, Bombus terrestris, to the island of Tasm
Aims With a growing population of women with congenital heart disease (CHD), pregnancies in this group are expected to increase. However, pregnancy in women with CHD is associated with increased adverse outcomes for both mother and child. The aim of this study was to evaluate pregnancy and foetal complications in women with CHD and to test their association with the modified WHO (mWHO) classificat
INTRODUCTION: Cognitive resilience refers to maintaining cognitive function despite Alzheimer's disease (AD) pathophysiology. METHODS: We analyzed amyloid-positive individuals across clinical stages of AD in two cohorts: the Amsterdam Dementia Cohort (ADC, N = 1036) and Alzheimer's Disease Neuroimaging Initiative (ADNI, N = 685). Cognitive resilience was conceptualized from a canonical correlation
The end Permian negative δ13C excursion is well known but its cause and chronology are still in question. In an attempt to decipher the timing and reasons for this strong decrease, we established high-resolution sedimentological, biostratigraphical and carbonate carbon isotopic studies in four sections in Iran (Abadeh, Shareeza, Zal and Djulfa) and two in Oman (Wadi Sahtan). The position of the se
δ13C data from Tethyan sections provide evidence of profound changes in the carbon cycle during the Lower Triassic. Sections from the Panthalassa realm were investigated to establish whether these variations are also present there. In the Jurassic accretionary wedges in Japan, exotic blocks having a Panthalassan affinity, have been incorporated. The majority of the blocks are pelagic cherts but ra
6 evaporite samples from the latest Permian to the late Lower Triassic have been sampled at marine carbonate sections in the Southern Alps. The sulphur isotope ratio of the sulphate has been determined to learn about the changes of the marine δ34S ratio during the investigated period, as it is known from the literature that a profound change from depleted to heavily enriched δ34S values occurred w
A post-extinction calcimicrobial cap rock occurs above the giant Permian skeletal carbonate platform exposed in the western Taurus Mountains (southern Turkey). It was formed during the main step of a very rapid and large-scale platform flooding (Earliest Triassic) and has been found also in other Tethyan localities. This calcimicrobial cap rock, 20 to 40 pm thick, consists of thrombolitic and stro
The Permian - Triassic boundary of the Çürük daǧsection (Taurus, Antalya Nappes, Turkey) was sampled for ostracodes. 38 species belonging to 22 genera were discovered. This ostracode fauna is the first one described throughout the Permian - Triassic boundary outside of South China. Six species are new: Sargentina pamucakensis Crasquin-Soleau n. sp., Bairdia kemerensis Crasquin-Soleau n, sp., Baird
The Siusi/Seis section has been measured for the δ13C signature across the Permian-Triassic Boundary (PTB) in high resolution on magnetostratigraphic samples from Scholger et al. (2000), enabling an exact correlation with magnetostratigraphic data. We show that the base of the short normal polarity magnetozone that has been reported from the evento-stratigraphic boundary correlates with a distinct
The Permian-Triassic Boundary sequence at Çürük Dag, near Antalya, Turkey, begins with a major erosion surface interpreted as being the Late Permian lowstand, on which lies ca 0·4m of grainstone/packstone composed of ooids, peloids and bioclasts. Most ooids are superficial coats on fragments of calcite crystals presumed to be eroded from crystal fans which are no longer present. The erosion surfac
The end-Permian mass extinction greatly affected the sedimentary record, but the sedimentary response was not limited to the Permian-Triassic boundary interval. This transformation extended to sedimentation that spanned the entire Early Triassic. Calcimicrobialites play an important role throughout this time interval, and at least four main events of anomalous carbonate deposition can be shown. A
Very few data on Early Triassic marine ostracods are available. In most of cases, the data concern the upper part of the Early Triassic. The çürük dağ section, located in the Western Taurides (Turkey), well stratigraphically constrained by conodonts and foraminifera, has been re-sampled for ostracod study. A significant fauna has been discovered in the Late Permian and the levels of the Earliest T
Stable carbon isotope curves derived from Lower Triassic carbonate rocks from three Iranian sections are established to investigate changes in the carbon cycle during the Early Triassic in this area. The sections are located in the south-center (Abadeh), north (Amol), and northwest (Zal) of Iran. All three curves show a similar pattern starting out with high δ13C values in the uppermost Permian de
With the aim to understand prolonged and repeated marine anoxia after the Triassic-Jurassic massextinction event, a continuously cored, 338 metre thick succession of Rhaetian to Toarcian sediments was retrieved close to the village of Schandelah near Braunschweig (Lower Saxony, northern Germany). Here, preliminary biostratigraphical, lithological, sedimentological, geochemical, and geophysical bor
In the Wadi Wasit area (Central Oman Mountains), Dienerian breccias are widespread. These breccias consist mostly of Guadalupian reefal blocks, often dolomitised, and some rare small-sized blocks of lowermost Triassic bivalve-bearing limestones, A unique block, with a size of about 200 m3, including Permian and earliest Triassic faunas has been studied in detail. The so-called Wadi Wasit block con
Much attention has been given to the negative δ13C anomaly nearly coincident with the Permian-Triassic boundary. New data indicate a stepwise decline in δ13C initiating before the Latest Permian extinction event followed by highly variable δ13C values during the remaining Early Triassic. δ13C values appear much less erratic as global metazoan diversity increased in the Middle Triassic. Given the p
