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This paper examines the local exponential stability (LES) of trajectories for nonlinear systems on Riemannian manifolds. We present necessary and sufficient conditions for LES of a trajectory on a Riemannian manifold by analyzing the complete lift of the system along the given trajectory. These conditions are coordinate-free which reveal fundamental relationships between exponential stability and
Klimatförändringar och social rättvisa är två sammanlänkade utmaningar för städer och kommuner. I takt med att miljö- och klimatkriserna förvärras blir behovet av att sammanlänka ekologisk och social hållbarhet alltmer centralt för städers och kommuners omställning. Tidigare separata åtgärder för dessa områden har ofta misslyckats med att tillvarata synergier och hantera motsättningar. Projektet u
Aim: To study academic, social and psychiatric outcomes among adults in the general population in southwestern Sweden. Groups of individuals born in 1998 and ineligible, eligible but not completed, and eligible and completed upper secondary school were followed in 2020. Methods: Data were retrieved from Statistics Sweden, the Swedish National Agency for Education, the Longitudinal Integrated Datab
Bacterial reverse transcriptases (RTs) are a large and diverse enzyme family. AbiA, AbiK and Abi-P2 are abortive infection system (Abi) RTs that mediate defense against bacteriophages. What sets Abi RTs apart from other RT enzymes is their ability to synthesize long DNA products of random sequences in a template- and primer-independent manner. Structures of AbiK and Abi-P2 representatives have rec
The royal warship Vasa sank on her maiden voyage in 1628. She was discovered in 1956 and in 1961, after 333 years at the bottom of the sea in the Stockholm harbour she was salvaged. Vasa, built mainly of oak, was one of the first major objects to be conserved with polyethylene glycol. She was sprayed continuously for 17 years followed by an 11 year long controlled drying procedure HBfors,[l]). In
OBJECTIVE: Radical cystectomy (RC) for bladder cancer is associated with an inherent risk of complications and even postoperative mortality. The number of hospitals performing RC has decreased in Sweden over time, and since a formal regional centralization in 2017 cystectomy care is currently provided by nine hospitals. MATERIAL AND METHODS: In the Swedish National Urinary Bladder Cancer Register
The study of microbial diversity over time and space is fundamental to the understanding of their ecology and evolution. The underlying processes driving these patterns are not fully resolved but can be studied using population genetic approaches. Here we investigated the population genetic structure of Gonyostomum semen, a bloom-forming phytoplankton species, across two continents. The species ap
The genome of cancer cells is unstable. Flaws in the DNA repair mechanisms of these cells can lead to the creation of gene fusions, where parts of two different genes are erroneously combined. Additionally, the expression of microRNAs (miRNAs), small regulatory molecules that control gene activity, is often dysregulated in cancer. In this thesis, we investigate miRNAs, gene fusions, and the interp
The sometimes rapid development of (new) threats and extraordinary events calls for a robust, flexible, and well-equipped civil crisis preparedness system to respond and limit the damage of crisis events. To achieve this, Swedish municipalities and regions are required by law to regularly perform and report risk and vulnerability analysis ‘bottom up’ to governmental agencies. When performed in lar
Background: Heart failure with reduced ejection fraction (HFrEF) is characterized by ventricular remodeling and impaired myocardial energetics. Left ventricular pressure-volume (PV) loop analysis can be performed noninvasively using cardiovascular magnetic resonance (CMR) imaging to assess cardiac thermodynamic efficiency. Objectives: The aim of the study was to investigate whether noninvasive PV
Metabolic rewiring is a key feature of cancer cells to support the demands of growth and proliferation. The metabolism of amino acids is altered in many cancers, including pancreatic cancer. The cellular uptake of amino acids is regulated by amino acid transporters, such as L-type amino acid transporter 1 (LAT1). Accumulating evidence suggests that LAT1 is overexpressed in pancreatic cancer and co
Solid-liquid interfaces are at the heart of a wide variety of phenomena. Their investigation requires experimental techniques with surface sensitivity such scanning probe microscopy and nonlinear optical techniques. In recent years, solid-liquid interfaces have been investigated with a novel approach based on the generation of high frequency acoustic and optical phonons. Due to the sensitivity of
Charges and their contribution to protein-protein interactions are essential for the key structural and dynamic properties of monoclonal antibody (mAb) solutions. In fact, they influence the apparent molecular weight, the static structure factor, the collective diffusion coefficient, or the relative viscosity, and their concentration dependence. Further, charges play an important role in the collo
Objectives To describe clinical and laboratory characteristics and outcomes in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and thyroid disease (TD). We also aimed to calculate incidence and identify predictors of TD in two large cohorts of patients with AAV. Methods The study comprised 644 patients with AAV in a population-based cohort from southern Sweden
