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PURPOSE OF REVIEW: Small cell lung cancer (SCLC) is an aggressive disease with a poor prognosis, whereas its metastatic capacity carries a predilection for the brain. Although prophylactic cranial irradiation (PCI) has been used to address this problem, upcoming alternatives might necessitate reflection of its application in SCLC treatment. RECENT FINDINGS: The addition of immunotherapy to treatme

There are some evidences that hypogammaglobulinemia in newly diagnosed diffuse large B cell lymphoma (DLBCL) is a predictor for inferior outcome, but the risk for infection-related admissions specifically related to hypogammaglobulinemia is not known. The aim was to explore if hypogammaglobulinemia in untreated DLBCL in a Swedish cohort was associated with inferior outcome, and to assess the relat

The efficiency of ultrafiltration (UF) of acidified skim milk (SM) is impaired by protein aggregation and mineral scaling. The aim of this study is to assess the potential of acidification by electrodialysis with bipolar membranes (EDBM), in comparison with citric acid (CA), prior to the UF process on filtration performance, fouling and composition of the protein concentrates. Electro-acidificatio

The annexation of Crimea, the subsequent insurgency of Russian-backed separatists in the Donbas region of Ukraine in 2014 and the current full-scale Russian invasion of Ukraine have led to different responses from political elites, diasporas and migrants currently residing in different European countries. The historic decision of Sweden to send defence weapons to Ukraine as well as to apply for NA

Coacervates of oppositely charged milk proteins are used in functional food development, mainly to encapsulate bioactives. To uncover the driving forces behind coacervates formation, we study the association of lactoferrin and β−lactoglobulin at amino-acid level detail, using molecular simulations. Our findings show that inter-protein electrostatic interactions dominate and are, surprisingly, equa

The aim of this article is to understand how a group of subsidised employees constructed a collective identity and symbolic community, and the role the municipal labour market programme played in that process. Further, it explores whether and how a shared collective identity and symbolic community may provide an explanation for how the ‘successful intervention/lock-in effect paradox’ occurs when u

BACKGROUND: Although death in old age is unavoidable, premature death-defined here as death before age 70 years-is not. To assess whether halving premature mortality by 2050 is feasible, we examined the large variation in premature death rates before age 70 years and trends over the past 50 years (1970-2019), covering ten world regions and the 30 most-populous nations. This analysis was undertaken

Though child anthropometric failure (CAF) is a persistent problem in India, previous studies have often neglected state-level variance and aggregated moderate and severe CAF categories. This study addresses this gap by examining moderate and severe malnutrition across India's states and union territories (UTs) from 1993 to 2021. Data of children under 2 years old from five waves of National Family

This chapter provides a brief yet comprehensive overview of the state-of-the-art in semiconductor characterization using spectroscopic ellipsometry. The concept of ellipsometry as optical technique to determine the state of polarization of light reflected or transmitted from complex-structured and multiple layered semiconductor materials is introduced and laid out in the framework of the Jones vec

In this letter, we demonstrate low-frequency noise (LFN) characterization of an InAs vertical gate-all-around hafnium-zirconium oxide (HZO) ferroelectric field-effect transistor (FeFET). The LFN characteristics are investigated before and after ferroelectric switching for up to 1000 cycles in the FeFET. The evolution of such cycling reveals distinct differences in the LFN for the two polarization

This article examines the debate surrounding an ice hockey museum in Örnsköldsvik, Sweden. In 2013, the local ice hockey club, Modo Hockey, received a loan from Örnsköldsvik municipality to build an ice hockey museum in its home arena. The ice hockey museum was a part of a bigger heritage project that involved various sites in the area around Örnsköldsvik, with the intention of increasing the numb

This article examines the role of equipment managers in Swe-dish male elite ice hockey. This is in relation to a major shiftin terms of professionalisation and commercialisation thathas occurred within elite ice hockey as a whole during thepast 40-50 years. The article themes are identified throughan investigation of how equipment managers are portraitedby the Swedish media.Additionally, in order

In the light of recent developments in the design of structural materials, micro-architected heterogenous-structure metals are considered among most structurally efficient. In this work, a new technique for Local High Pressure Torsion (L-HPT) enabling the creation of heterogeneous structures through localised deformation processing in sheet metals by impeding a rotating punch is proposed. Using AA

BackgroundUnderstanding the interplay between different pathologies is essential for correlating specific pathologies with cognitive symptoms and predicting the clinical effects of emerging therapies later on. This thesis investigates interactions among biomarkers of small vessel disease (SVD), neuroinflammation, and Alzheimer’s disease (AD), their relation to infection in the brain parenchyma, an