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Syndecan-2 is a heparan sulfate proteoglycan that has a cell adhesion regulatory domain contained within its extracellular core protein. Cell adhesion to the syndecan-2 extracellular domain (S2ED) is β1 integrin dependent; however, syndecan-2 is not an integrin ligand. Here the protein tyrosine phosphatase receptor CD148 is shown to be a key intermediary in cell adhesion to S2ED, with downstream β
The ligand-binding domain of Fbl (the fibrinogen binding protein from Staphylococcus lugdunensis) shares 60% sequence identity with ClfA (clumping factor A) of Staphylococcus aureus. Recombinant Fbl corresponding to the minimum fibrinogen-binding region (subdomains N2N3) was compared with ClfA for binding to fibrinogen. Fbl and ClfA had very similar affinities for fibrinogen by surface plasmon res
Malaria is a potentially life-threatening disease with approximately half of the world’s population at risk. Young children and pregnant women are hit hardest by the disease. B cells and antibodies are part of an adaptive immune response protecting individuals continuously exposed to the parasite. An infection with Plasmodium falciparum can cause dysregulation of B cell homeostasis, while antibodi
Sediment transport in the cross-shore (CS) and associated changes in the beach profile, especially during storms, have been topics of widespread concern. Since storms are often accompanied by high water levels and large waves, large quantities of sand from the beach and the dune are typically transported offshore, leading to severe beach and dune erosion, which threatens the integrity of buildings
Analysis of a 13-year long, high-resolution data series on beach profiles, surveyed from 1981 to 1993 by the Army Field Research Facility (FRF) at Duck, North Carolina, in the United States, was analyzed in order to understand the temporal and spatial characteristics of the dune response. Various statistical methods were employed in this analysis. The profile survey data set was analyzed with rega
Venous thromboembolism (VTE) is the third most common cardiovascular disease. Low amount of mitochondrial DNA copy number (mtDNA-CN) has been associated with arterial cardiovascular disease (CVD) and reflects mitochondrial dysfunctions. However, whether mtDNA-CN is associated with VTE has not been determined. To examine the association between mtDNA-CN and incident VTE among middle-aged women. 691
Utställning, Prins Eugens Waldemarsudde, 24/4 – 3/10 2021.Det är hos den unga generationens kreatörer som idéer om framtidens mode först tar form. I utställningen Future Nordic Fashion visas ett urval visionära kreationer, som har skapats av några av de främsta nyexaminerade modedesigners inom ramen för den nordiska designtävlingen Designers´ Nest. Teman som lyfts fram i utställningen är dagsaktue
Purpose: The purpose of the paper is to theorize how to develop student entrepreneurs' ability to reflect by means of a learning activity called the entrepreneurial diary, which seeks to develop self-regulated learners capable of intelligent entrepreneurial action. The importance of self-regulation in entrepreneurship is linked to the individual's ability to make judgments under conditions of unce
Bin är en del av den biologiska mångfalden och bidrar dessutom med pollineringstjänster i våra odlade grödor och trädgårdsväxter. Men många arter är hotade och minskar i antal, med minskande biologisk mångfald som följd. Vilka konsekvenser får detta för jordbruksproduktionen? Genom att identifiera hoten och hitta motåtgärder finns det hopp om en väg framåt som gynnar alla.
Climate warming has caused the seasonal timing of many components of ecological food chains to advance. In the context of trophic interactions, the match–mismatch hypothesis postulates that differential shifts can lead to phenological asynchrony with negative impacts for consumers. However, at present there has been no consistent analysis of the links between temperature change, phenological async
Dual-energy X-ray absorptiometry (DXA)-derived appendicular lean mass/height2 (ALM/ht2) is the most commonly used estimate of muscle mass in the assessment of sarcopenia, but its predictive value for fracture is substantially attenuated by femoral neck (fn) bone mineral density (BMD). We investigated predictive value of 11 sarcopenia definitions for incident fracture, independent of fnBMD, fractur
Purpose: Lemierre syndrome is a life-threatening condition characterized by head/neck bacterial infection, local suppurative thrombophlebitis and septic embolic complications in a range of sites of distant organs. No prior study focused on the course and characteristics of ophthalmic complications of Lemierre syndrome. Methods: We analysed data of 27 patients with ophthalmic complications from a l
Internally structured block copolymer-surfactant particles are formed when the complex salts of ionic-neutral block copolymers neutralized by surfactant counterions are dispersed in aqueous media. Here, we report the1H NMR signal intensities and self-diffusion coefficients (D, from pulsed field gradient nuclear magnetic resonance, PFG NMR) of trimethyl alkylammonium surfac-tant ions and the poly(a
Little is known about the extent of variation and activity of naturally occurring milk glycosidases and their potential to degrade milk glycans. A multi-omics approach was used to investigate the relationship between glycosidases and important bioactive compounds such as free oligo-saccharides and O-linked glycans in bovine milk. Using 4-methylumbelliferone (4-MU) assays activities of eight indige
Human rely profoundly on tactile feedback from fingertips to interact with the environment, whereas most hand prostheses used in clinics provide no tactile feedback. In this study we demonstrate the feasibility to use a tactile display glove that can be worn by a unilateral hand amputee on the remaining healthy hand to display tactile feedback from a hand prosthesis. The main benefit is that users
