The filaggrin gene and the dermal absorption of chemicals Filaggrin is a monomeric protein highly expressed in the outer layer of the epidermis and important for building up the skin barrier. About 7-10% of the European popula-tion have a loss-of-function mutation (so called null mutation) in the filaggrin gene (FLG), which leads to a reduction or loss of the filaggrin protein. The aim of this

A new probiotic for the cure of diabetes Metabolic diseases such as obesity and type 2 diabetes are becoming increasingly common worldwide and are major causes of disability and death indicating an urgent need for interventions. Emerging evidence points to a central role of gut microbiota in metabolism, for example blood glucose metabolism and appetite regulation. Furthermore, intervention with

Lysande protein ska hjälpa spåra ändringar vid alzheimers sjukdom Demens är ett syndrom som påverkar en stor del av populationen vid högre ålder. Syndromet yttrar sig genom att påverka personers kognitiva förmågor, huvudsakligen minnet. Frekvensen kommer fortsätta att öka med den åldrande populationen. Den vanligaste och mest välkända varianten av demens är alzheimers sjukdom. Som alla vet är deApolipoprotein E4 (ApoE4) is the biggest genetic risk factor for Alzheimer’s disease. While it is known to transport cholesterol to neurons the localization of the protein has not yet fully been mapped. Levels of amyloid precursor protein (APP) and its cleavage product amyloid beta (Aβ), the main component of amyloid plaques, in transfected cells were determined using western blot. Green fluoresce

The purpose of this thesis is to study if software defined networks (SDN) can function as a second layer of defence in safety critical sensor networks. SDNs are controlled and topologically defined by a logically centralised control unit. The centralised control logic makes it possible to control the behaviour of the network, and react to network events. In this thesis we examine if and how SDNs c

Mexico has experienced the dramatic escalation of crime and violence in an organized form since the 1990s, and have also witnessed the highest number of homicides in the last ten years. It has adversely affected the national security, economic growth and social development with an especially detrimental effect on youth in Mexico. This study examines the direct and indirect impacts of drug trade-re

Biobased economy is becoming a central strategy to decouple industrial production from fossil feedstock and thus to tackle global warming. Consequently there has been an interest in developing technologies for the production of chemicals, materials, and fuels from renewable bio-based feedstock. This can be achieved thanks to industrial biotechnology and metabolic engineering. Protocatechuic acid (

With the development and structural transformation of an economy the dynamics of labour force participation change. The female experience of development and labour force participation is different to that of the male. Different levels of development and educational attainment, compounded by social expectations, correspond differently in effecting the likelihood for a woman to participate in the la

Magnesium chelatase is a heterotrimeric enzyme complex, which catalyzes the insertion of Mg2+ into protoporphyrin IX. The enzyme is composed of three protein subunits BchI, BchD and BchH of approximately 40, 70 and 140 kDa, respectively. In barley (Hordeum vulgare L.) the subunits are referred to as Xantha-H, Xantha-G and Xantha-F. In this study, genes encoding the magnesium chelatase subunits of

Målbilder och berättelsers betydelse för integreringen av målbilder för hållbara transporter Sveriges klimatmål inom transportsektorn innebär att mängden koldioxidutsläpp inom transporter ska minska drastiskt de kommande åren. Utsläppen från inrikes transporter, exklusive inrikes flyg, ska minska med minst 70% senast år 2030 jämfört med 2010 (Naturvårdsverket, 2018). Som klimatstrategiskt verktyAs a climate tool, investments in pedestrian, bicycle and public transport can be important for reducing climate emissions while investments in these sustainable modes of transport can have more effects to achieve other sustainability goals such as public health, reduced noise, greener outdoor environments, reduced particle emissions and space for creative urban planning. How does a selection of S

Ice Nucleation Proteins (INP) are integral membrane proteins that aid in forming ice crystals. As the name suggests INP help form ice crystals by forming the nucleus around which water molecules align themselves. Under favourable conditions, these water molecules freeze when associated with the protein. INP are present in numerous organisms, the focus of this project, however, was INP from the bac

Throughout the 21st century, Russian policy has been identified primarily by one unalterable person – Vladimir Putin. His coming to power as president of the Russian Federation marked a new course in Russia’s policy. Putin’s political decisions and visions are of considerable importance in Russian domestic policy as much as in international politics. The aim of this paper is to study how Vladimir

The aim of this thesis is to further explore the relationship between the establishment of public transport and gentrification processes. There have been various studies showing the importance of public transport as a contributing factor in providing access to work and other important institutions in urban areas. However, recent studies have also shown that the establishment of public transport in