Introduction Severe osteogenesis imperfecta (OI) is a debilitating disease with no cure or sufficiently effective treatment. Mesenchymal stem cells (MSCs) have good safety profile, show promising effects and can form bone. The Boost Brittle Bones Before Birth (BOOSTB4) trial evaluates administration of allogeneic expanded human first trimester fetal liver MSCs (BOOST cells) for OI type 3 or severe

Semiconductor technology constantly advances, enabling integrated circuits (ICs) with increasingly numerous, faster, and smaller transistors. While this progress offers many benefits, it also presents new challenges, such as tighter margins, wear-outs, and process variations. To effectively tackle these challenges, the conventional approach of using external test instruments during manufacturing t

Tunnel Field-Effect Transistors (TFETs) offer more energy efficient alternative to CMOS for design of low power circuits. In spite of this potential, circuits based on TFETs have not been experimentally demonstrated so far. In this letter, we explore TFET fabrication and basic functionality of n-TFET based circuits in the following configurations: a current mirror, a diode-connected inverter, and

It is irrefutable that the material value chains of the modern economy need to become more circular to mitigate not only climate change but also biodiversity loss and pollution associated with increasing use of natural resources. Contributions to these impacts, known as the triple planetary crisis, occur at all stages of product value chains, from primary production to use stages and ineffective e

The introduction of autonomous machines (AMs) in human domains has raised challenging questions about the attribution of responsibility; referred to as the responsibility gap. In this paper, we address the gap by arguing that entities should not be granted the freedom of action unless they can also recognise the same right for others—and be subject to blame or punishment in cases of undermining th

In this paper, we study scalar mediator induced nonstandard interactions (SNSIs) in the context of the ESSnuSB experiment. In particular, we study the capability of ESSnuSB to put bounds on the SNSI parameters and also study the impact of SNSIs in the measurement of the leptonic CP phase δCP. Existence of SNSIs modifies the neutrino mass matrix and this modification can be expressed in terms of th

We explore the potential of nanocrystals (a term used equivalently to nanoparticles) as building blocks for nanomaterials, and the current advances and open challenges for fundamental science developments and applications. Nanocrystal assemblies are inherently multiscale, and the generation of revolutionary material properties requires a precise understanding of the relationship between structure

Economic, knowledge-based, legislative, organizational, and political barriers hinder the efficient implementation of sustainable stormwater management in Sweden.A comprehensive approach involving legislative clarity, improved financial models, enhanced collaboration, and a shift in political priorities towards blue-green infrastructure is needed.Balancing urban development with urban green spaces

Swedish media, using Mossad documents, revealed that criminal networks in Sweden collaborate with Iran's regime. Justice Minister Gunnar Strömmer confirmed Iran's use of criminals for violent acts. Since 1979, Iran has destabilized regions via its intelligence and the Islamic Revolutionary Guard Corps (IRGC). Earlier this year, IRGC members plotted to kill Swedish Jews. The Security Police view Ir

The presence of an elite group in civil society elicits a discursive friction between the long-standing normative understanding of civil society, acting as a check on government overreach and autocratic tendencies, and elite theories. Robert Michels’s iron law of oligarchy posits that as individuals rise in the ranks to become organizational leaders, they begin to take on elite attributes, and the

This paper constructs the first estimates of Irish regional GDP over the twentieth century and traces the relative economic performance of Ireland’s regions since independence. Using an array of data sources available at a county level, output inAgriculture, Industry and S ervices in benchmark census years is estimated. Applying a variety of alternative measures, we find a reduction in regional in

Due to climate change, future weather conditions will become more extreme. During recent years, several severe damages have been caused by heavy rainfalls in combination with riverine events. Even though the effects of compound events are known to be influential for flood hazard, the method for investigating these types of events is a novel area of expertise. In this study, a methodology was devel

This paper constructs annual GDP estimates for Ireland (1924-47) to join the first complete official aggregates. The new series is deployed to revisit Ireland’s economic performance in the post-independence decades. Ireland’s economy grew at 1.5 per cent per annum and average living standards improved by 40 per cent. The bulk of this growth was due to labour productivity improvements. Starting in