Applying Large-Scale Transcriptomic Data to Analyze In Vitro Human Hypothalamic Differentiation Protocols
The increased prevalence of obesity is causing challenges on individual and socioeconomic levels. Neuronal subtypes of the hypothalamus control appetite regulation through the secretion of peptide hormones and neurotransmitters. Our limited knowledge of early molecular patterning of the human hypothalamus sets a challenge to design human in vitro models for cellular studies and drug screening. In