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Protein dynamics have been investigated on a wide range of time scales. Nano- and picosecond dynamics have been assigned to local fluctuations, while slower dynamics have been attributed to larger conformational changes. However, it is largely unknown how fast (local) fluctuations can lead to slow global (allosteric) changes. Here, fast molecule-spanning dynamics on the 100 to 200 ns time scale in
Background Breathlessness and fatigue are common symptoms in older people. We aimed to evaluate how different breathlessness dimensions (overall intensity, unpleasantness, sensory descriptors, emotional responses) were associated with fatigue in elderly men. Methods This was a cross-sectional analysis of the population-based VAScular disease and Chronic Obstructive Lung Disease (VASCOL) study of 7
The prognostic impact of PICALM::MLLT10 status in childhood leukaemia is not well described. Ten International Berlin Frankfurt Münster-affiliated study groups and the Children's Oncology Group collaborated in this multicentre retrospective study. The presence of the PICALM::MLLT10 fusion gene was confirmed by fluorescence in situ hybridization and/or RNA sequencing at participating sites. Ninety-
Decentralized water reuse technologies are increasingly being explored as a transformative approach for complementing centralized water and wastewater infrastructure. A transition to onsite water reuse requires a better understanding of how urban infrastructures are governed. While governance tends to be discussed within ideal types─i.e., hierarchy, market, and network─researchers increasingly rec
In 2008, Sweden changed its labour-migration policy to facilitate more labour migration from countries outside the EU. Most state ambitions to shape labour migration, including practices such as the use of labour-market tests and the assessment of migrants' human capital, were abandoned and the responsibility to select migrants was transferred to employers. We use Swedish register data and adopt a
Background: Electrocardiographic detection of patients with occlusion myocardial infarction (OMI) can be difficult in patients with left bundle branch block (LBBB) or ventricular paced rhythm (VPR) and several ECG criteria for the detection of OMI in LBBB/VPR exist. Most recently, the Barcelona criteria, which includes concordant ST deviation and discordant ST deviation in leads with low R/S ampli
In this work, we introduce a novel approach for designing the transmit frequency offset scheme based on Cramér-Rao lower bound (CRLB) minimization for a frequency diverse array multiple-input multiple-output (FDA-MIMO) radar. The problem originates in non-uniform FDA radar where each frequency offset scheme derives from a specific mathematical model, but where no optimization is conducted with res
The problem of finding maximum (or minimum) witnesses of the Boolean product of two Boolean matrices (MW for short) has a number of important applications, in particular the all-pairs lowest common ancestor (LCA) problem in directed acyclic graphs (dags). The best known upper time-bound on the MW problem for n × n Boolean matrices of the form O(n2.575) has not been substantially improved since 200
The access and use of administrative health data in Germany is limited by several factors. Due to the large number and heterogeneity of data holders, data are usually only available in fragmented form, and access is often regulated in a non-transparent manner. Linkage of health data with other data sources is hardly possible for legal and logistic reasons. These limitations directly affect the abi
Soil microbes function as decomposers in terrestrial ecosystems. They break down the organic matter, which plays a significant role in supplying nutrients to plants, but also in regulating biogeochemical cycling which feeds back to climate change. Like other organisms, soil microbes can be limited by the availability of essential resources, which could consequently affect their ability to decompos
Denna forskning fördjupar sig i frystorkning, en essentiell process inom läkemedels- och probiotikaindustrin, för att bättre förstå faktorer som påverkar probiotisk stabilitet under lagring. Frystorkningsprocessen och sammansättningen av frystorkade produkter påverkar signifikant probiotikas stabilitet, men faktorer som materialens inkapslingsegenskaper förblir relativt outforskade och kräver ytteThis research dives into the intricate world of freeze-drying, an essential process in pharmaceutical and probiotic industries, to better understand the factors affecting probiotic stability during storage. The process of freeze-drying and the composition of freeze-dried products significantly affect the stability of probiotics, yet factors such as the material’s encapsulation properties remain re
This chapter offers a theoretical approach to the study of humorous digital memes. Using vaccination and pandemic policy memes on Reddit as examples, the chapter’s main contribution is an understanding of memes as forms of symbolic levelling that reflect and construct civic trust or distrust. Arguing for a theoretically informed methodological approach sensitive to memes’ polysemic ambiguity, seve
When freely viewing a scene, the eyes often return to previously visited locations. By tracking eye movements and coregistering eye movements and EEG, such refixations are shown to have multiple roles: repairing insufficient encoding from precursor fixations, supporting ongoing viewing by resampling relevant locations prioritized by precursor fixations, and aiding the construction of memory repres
