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Generation of induced pluripotent stem cells (iPSCs) is a process whose mechanistic underpinnings are only beginning to emerge. Here, we applied in-depth quantitative proteomics to monitor proteome changes during the course of reprogramming of fibroblasts to iPSCs. We uncover a two-step resetting of the proteome during the first and last 3 days of reprogramming, with multiple functionally related
Regenerative tissues such as the skin epidermis, the intestinal mucosa or the hematopoietic system are organized in a hierarchical manner with stem cells building the top of this hierarchy. Somatic stem cells harbor the highest self-renewal activity and generate a series of multipotent progenitors which differentiate into lineage committed progenitors and subsequently mature cells. In this report,
A complex interplay between the microbiota and the host immune system is evidenced to shape the immune system throughout life, but little is known about the microbial effect on key players of the adaptive immune system, the B2 B cells. In the presented study, we have evaluated the effect of commensal bacteria on B cell ontogeny and function, with the focus on B2 B cells of spleen and Peyer's patch
Postnatal intestinal development is a very dynamic process characterized by substantial morphological changes that coincide with functional adaption to the nutritional change from a diet rich in fat (milk) to a diet rich in carbohydrates on from weaning. Time-resolved studies of intestinal development have so far been limited to investigation at the transcription level or to single or few proteins
Identification and relative quantification of hundreds to thousands of proteins within complex biological samples have become realistic with the emergence of stable isotope labeling in combination with high throughput mass spectrometry. However, all current chemical approaches target a single amino acid functionality (most often lysine or cysteine) despite the fact that addressing two or more amin
The general objective of this thesis was to increase the knowledge of how mental health and school performance are associated and how interventions may be designed and implemented to enhance the two.The data used in the four quantitative studies on which this thesis is based were derived from two age cohorts of students attending 14 elementary schools in two cities in the southern part of Sweden.
This dissertation examines the changing time allocation of men and women at the turn of the 21st century in Sweden, an interesting case given its strong position concerning female labor force participation, maternal employment, and gender equality. The aim is to examine to what extent gender and parenthood affect various types of time allocation, both in the labor market and household, and provide
Abstract The chemistry of CO and D2O, individually adsorbed or co-adsorbed, on epitaxial thin films of samaria on Pt(111) was studied by temperature-programmed desorption spectroscopy (TPD). Continuous thin films as well as discontinuous films composed of samaria islands on bare Pt(111) were prepared. Their comparative study indicates that Sm2O3 islands provide lattice oxygen at their perimeter fo
The rugged field and group of trees between housing estates or next to the railroad tracks, the left-over space of deserted industrial areas, the vacant demolition site of a central city block – they could all be termed ‘urban voids’. However, they are often anything but voids, in a literal sense, as they are not empty, or deserted. Yet they are ‘urban voids’, lacking an evident function, or a def
Climate change is expected to cause extensive vegetation changes in the Arctic: deciduous shrubs are already expanding, in response to climate warming. The results from transect studies suggest that increasing shrub cover will impact significantly on the surface energy balance. However, little is known about the direct effects of shrub cover on permafrost thaw during summer. We experimentally quan
In recent years, we have seen the development of a more relational approach to territoriality. This perspective, which focuses on events rather than space, also opens up for an elaboration of temporal aspects of territorial production. In this study, I investigate the central urban square, Stortorget, in Malmö, Sweden, in order to develop a discussion of a time-space territorology. In 1978, Korose
Aerosol particles affect Earth’s climate system by scattering and absorbing light. The perturbation of the climate system caused by a change in aerosol configuration due to anthropogenic emissions has recently improved. However, the radiation balance and hydrological cycle of Earth are also highly influenced by clouds: a small change in cloud configuration can have a large effect on the climate. C
The purpose of this paper is to highlight the connection between castles, commerce and urbanity in Scandinavia. This is made by comparing three Swedish royal castles. The castle in Stockholm has its roots in the twelfth or thirteenth century and was founded in connection with the contemporary town. Here are indications that the merchants in an early phase lived in the bailey of the castle. The casIt is generally accepted that there were well-established relationships between castles and commerce in medieval Sweden. However, to date, the complexities of those relationships have arguably not been fully explored. Through focusing on archaeological evidence from three very different examples, Stockholm, Borgholm and Piksborg, this paper seeks to illustrate the variety of often intimate and com
Objectives Children and young people growing up in a farm environment run a greater risk of being injured or dying in an accident than their non-farming counterparts. This study examines farming parents' attitudes and experiences of having their children grow up on farms, one of the most dangerous work environments as their home, everyday environment and playground. Method Data were collected usin
