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Background: Diabetes is associated with systemic complications. Prevalence of diabetic nephropathy, and retinopathy, in type 1 diabetes is declining but it is not known if this is true also for diabetic neuropathy. Aim: To investigate the relationship between large fiber diabetic neuropathy and other diabetic complications. Materials and methods: Neuropathy, defined here as large fiber neuropathy,Background: Diabetes is associated with systemic complications. Prevalence of diabetic nephropathy, and retinopathy, in type 1 diabetes is declining but it is not known if this is true also for diabetic neuropathy.Aim: To investigate the relationship between large fiber diabetic neuropathy and other diabetic complications.Materials and methods: Neuropathy, defined here as large fiber neuropathy, w

As part of the green transition, a current trend in the construction sector is to utilize more wood and lightweight composites, aiming at a reduction of the embodied energy in buildings. At the same time, with a focus on circularity and reuse, large-span structures are preferable, since they provide more flexibility for future uses of the building. The mix of large spans and lightweight structures

The surface reactivity during CO oxidation over Pd(1 1 1) and Pd75%Ag25%(1 1 1) single crystals has been investigated using near ambient pressure X-ray photoelectron spectroscopy (NAP-XPS) under excess oxygen conditions (p ≈ 2 mbar, O2:CO=10). The (√6×√6) Pd5O4 surface oxide is present on Pd(1 1 1) when the surface is highly active under the applied conditions. The CO2 formation profile follows a

Purpose: The purpose of this study was to investigate how Registered Nurse Anesthetists (RNAs) who have been working for nongovernmental organizations in low- and middle-income countries perceive their role in global health. Design: A qualitative design was used in this study. Methods: Data were collected by means of semistructured interviews with 11 participants who met the inclusion criteria, an

The atmospheres of ultra-hot Jupiters are highly interesting and unique chemical laboratories. Due to the very high atmospheric temperatures, their chemical composition is dominated by atoms and ions instead of molecules, and the formation of aerosols on their day-sides is unlikely. Thus, for these planets detailed chemical characterisations via the direct detection of elements through high-resolu

The spatial distribution of elemental abundances and their time evolution are among the major constraints to disentangling the scenarios of formation and evolution of the Galaxy. Aims. In this paper we used the sample of open clusters available in the final release of the Gaia-ESO survey to trace the Galactic radial abundance and abundance-to-iron ratio gradients, and their time evolution. Methods

BACKGROUND: Forefoot gangrene in patients with diabetes is a severe form of foot ulcers with risk of progress and major amputation. No large cohort studies have examined clinical characteristics and outcome of forefoot gangrene in patients with diabetes. The aim was to examine clinical characteristics and outcome of forefoot gangrene in patients with diabetes admitted to a diabetic foot centre.MET

The Soil and Water Assessment Tool (SWAT) model has been widely applied for simulating the water cycle and quantifying the influence of climate change and anthropogenic activities on hydrological processes. A major uncertainty of SWAT stems from the poor representation of vegetation dynamics due to the use of a simplistic vegetation growth and development module. Using long-term remote sensing-bas

Background and purpose — The EQ-5D is a patient-reported outcome measure (PROM). To make priorities and allocate resources between patients and surgical procedures it is necessary to evaluate outcome differences, which is why comparing PROMs between registers is important. We compared EQ-5D data and the follow-up rate for selected diag-noses reported to Swedish orthopedic registers before and 1 ye

Extracellular vesicles (EVs) have emerged as a central mechanism of intercellular communication in physiology and disease. EVs participate in paracrine exchange of nucleic acids as well as lipids, proteins, and glycans to elicit a complex biological response in target cells. Proteoglycans (PGs) are widely expressed in EV-producing cells and are sorted to the membrane of secreted EVs to participate

Denna vägledning har som syfte att bidra till vägledning kring kommunikation i samband med sanering efter kärnteknisk olycka med nedfall. Fokus är inriktat på kommunikation med allmänheten. Vägledningen består av resonemang, principer att beakta, frågor att reflektera över och några konkreta råd.

The JUNGFRAU 4-megapixel (4M) charge-integrating pixel-array detector, when operated at a full 2 kHz frame rate, streams data at a rate of 17 GB s-1. To operate this detector for macromolecular crystallography beamlines, a data-acquisition system called Jungfraujoch was developed. The system, running on a single server with field-programmable gate arrays and general-purpose graphics processing uni

Pregnancy-related factors are important for short- and long-term health in mothers and offspring. The nationwide population-based Swedish Medical Birth Register (MBR) was established in 1973. The present study describes the content and quality of the MBR, using original MBR data, Swedish-language and international publications based on the MBR. The MBR includes around 98% of all births in Sweden.

Software corpora are crucial for evaluating research artifacts and ensuring repeatability of outcomes. Corpora such as DaCapo and Defects4J provide a collection of real-world open-source projects for evaluating the robustness and performance of software tools like static analysers. However, what do we know about these corpora? What do we know about their composition? Are they really suited for our

In Fedotova and others v Russia issued on 17 January 2023, the Grand Chamber of the European Court of Human Rights (ECtHR or the Court), held that Russia had breached its positive obligation to secure the applicants’ right to respect for their private and family life under Article 8 of the Convention by failing to provide any form of legal recognition and protection for same sex couples.In a post

Generating and analyzing overlapping peptides through multienzymatic digestion is an efficient procedure for de novo protein using from bottom-up mass spectrometry (MS). Despite improved instrumentation and software, de novo MS data analysis remains challenging. In recent years, deep learning models have represented a performance breakthrough. Incorporating that technology into de novo protein seq

En presentation av den allmänna borgutvecklingen inleder en katalogisering av 166 skånska borgplatser. Därefter presenteras 44 borgar med en fyllig beskrivning, bilder, rekonstruktioner samt analogt kartmaterial och en digital möjlighet att finna den aktuella lokalen.

The activity of the manganese (Mn) efflux transporter SLC30A10 in the liver and intestines is critical for Mn excretion and preventing Mn toxicity. Homozygous loss-of-function mutations in SLC30A10 are a well-established cause of hereditary Mn toxicity. But, the relationship between more common SLC30A10 polymorphisms, Mn homeostasis, and disease is only recently emerging. In 2021, the first coding

Research demonstrates that digital technologies stimulate industrial transformation by enabling new interdependencies with firms outside and across firm and industry boundaries. However, we know little about the degree of novelty and breadth of digital technologies that have the potential to transform industries. Understanding the degree of novelty (spanning from radical to incremental) and breadt