Background:Prostate cancer (PCa) is characterized by high tumor heterogeneity. In 2005, the fusion between the androgen-regulated gene TMPRSS2 and members of the ETS family was discovered in prostate cancer. In particular, fusion of TMPRSS2 with ERG was found in approximately 50% of prostate cancers and considered as an early event in the onset of the disease. The prognostic value of this fusion i

Separating individual rare earth elements from a complex mixture with several elements is difficult and this is emphasized for the middle elements: Samarium, Europium and Gadolinium. In this study we have accomplished an overloaded one-step separation of these rare earth elements through preparative ion-exchange high-performance liquid chromatography with an bis (2-ethylhexyl) phosphoric acid impr

AIMS/HYPOTHESIS: Several genome-wide linkage studies have shown an association between diabetic nephropathy and a locus on chromosome 18q harbouring two carnosinase genes, CNDP1 and CNDP2. Carnosinase degrades carnosine (β-alanyl-L-: histidine), which has been ascribed a renal protective effect as a scavenger of reactive oxygen species. We investigated the putative associations of genetic variants

An easy-to-use sample environment reaction cell for X-ray based in situ studies of powders and small structured samples, e.g., powder, pellet, and monolith catalysts, is described. The design of the cell allows for flexible use of appropriate X-ray transparent windows, shielding the sample from ambient conditions, such that incident X-ray energies as low as 3 keV can be used. Thus, in situ X-ray a

In design of ground-source energy systems the thermal performance of the borehole heat exchangers is important. In Scandinavia, boreholes are usually not grouted but left with groundwater to fill the space between heat exchanger pipes and borehole wall. The common U-pipe arrangement in a groundwater-filled BHE has been studied by a three-dimensional, steady-state CFD model. The model consists of a

We document the role of entrepreneurial founder and venture capital (VC) partner co-ethnicity in shaping investment relationships. Co-ethnicity increases the likelihood that a VC firm invests in a company. Conditional on investment, co-ethnicity strengthens the degree of involvement by raising the likelihood of VC board of director involvement and increasing the size and scope of investment. These

Recently, two new phenomena linking stress field and reduction rates in anode-supported solid oxide fuel cells (SOFCs) have been demonstrated, so-called accelerated creep during reduction and reduction rate enhancement and nucleation due to stress (Frandsen et al., 2014). These complex phenomena are difficult to study and it is demonstrated here that energy-resolved neutron imaging is a feasible t

Seven countries (Denmark, France, Ireland, the Netherlands, Poland, Sweden, United Kingdom) collaborated to initiate a EURECCA (European Registration of Cancer Care) Upper GI project. The aim of this study was to identify a core dataset of shared items in the different data registries which can be used for future collaboration between countries.

This article studies the effect of alcohol consumption on the probability of long-term sickness-related absenteeism for women. Using Swedish matched survey and register data, we apply sample selection models to correct for nonrandom sampling into paid employment. There are three main findings of the study. First, diverging from the most prevalent consumption group (long-term light drinkers) is ass

Corridors are often considered to promote dispersal between habitat patches. In this paper, we study whether or not corridors induce colonisation of nunataks (ice-free areas in glacier surroundings) by promoting dispersal from lowland to the nunataks. On outlet glaciers, debris originating from nunataks forms the so-called medial moraines that stretch from the nunataks down-glacier to the lowland,

The synergistic interaction of two antibodies targeting the same protein could be developed as an effective anti-cancer therapy. Human epidermal growth factor receptor 2 (HER2) is overexpressed in 20-25% of breast and gastric cancer patients, and HER2-targeted antibody therapy using trastuzumab is effective in many of these patients. Nonetheless, improving therapeutic efficacy and patient survival

Two-particle correlations in relative azimuthal angle (Delta phi) and pseudorapidity (Delta eta) are measured in root S-NN = 5.02 TeV p + Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1 mu b(-1) of data as a function of transverse momentum (p(T)) and the transverse energy (Sigma E-T(Pb)) summed over 3.1 < eta < 4.9 in the direction of the Pb

Time-resolved spectroscopy has an emerging role among modern material-characterization techniques. Two powerful theoretical formalisms for systems out of equilibrium (and thus for time-resolved spectroscopy) are Non-Equilibrium Green’s Functions (NEGF) and Time-Dependent Density Functional Theory (TDDFT). In this chapter, we offer a perspective (with more emphasis on the NEGF) on their current cap

A simulation study of daylight autonomy in perimeter office rooms at high latitudes is presented where the following variables are studied: Glazing-to-wall ratios (GWR), climate, orientation, inner surface reflectance, glazing visual transmittance, Venetian blind management and electric lighting dimming and switching systems. Based on daylight utilisation alone, the results indicate an optimal GWR

Live surgery is an important part of surgical education, with an increase in the number of live surgery events (LSEs) at meetings despite controversy about their real educational value, risks to patient safety, and conflicts of interest.

Abstract in UndeterminedObjective: This study examined the effects of chronic focal lesions to the lateral prefrontal cortex (LPFC) or orbitofrontal cortex (OFC) on neuropsychological test performance and self-reported executive functioning in everyday living. Methods: Fourteen adults with OFC lesions were compared to 10 patients with LPFC injuries and 21 healthy controls. Neuropsychological tests

Objective:To investigate the association between maternal pregnancy and estimated postnatal serum concentrations of the organochlorines 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) and body mass index (BMI) z-scores in five to nine-year-old children.Methods:Maternal sera from the INUENDO birth cohort (2002-2004) comprising mother-child pair

Photoexcitation of conjugated polymerfullerene blends results in population of a local charge transfer (CT) state at the interface between the two materials. The competition between recombination and dissociation of this interfacial state limits the generation of fully separated free charges. Therefore, a detailed understanding of the CT states is critical for building a comprehensive picture of t

Whether orthostatic hypotension (OH) is a risk factor for cardiovascular morbidity and death is uncertain. Currently available evidence derives from non-homogeneous and partly ambiguous studies.