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Bakgrund: Sepsis är ett allvarligt sjukdomstillstånd som årligen drabbar omkring 48,9 miljoner människor globalt. Sjukdomsförloppet är snabbt och komplext och på grund av sepsis höga mortalitet är det viktigt att sjuksköterskan är uppmärksam och har förmåga att identifiera tillståndet tidigt. Syfte: Syftet var att beskriva sjuksköterskans erfarenheter av att tidigt upptäcka patienter med sepsis. M
The 2010s have raised questions about the influence of small central banks in an integrated economy. This thesis investigates the efficacy of the Swedish Riksbank and the effect of economic integration since the adoption of a floating exchange rate in 1993. Theoretically, I examine how financial integration and trade may impact the Mundell-Fleming trilemma. To investigate the impact of integration
The purpose of this study was to increase an understanding of how school counselors in Sweden reason about the social problem with truants, “Hemmasittare '' in Swedish, and how the elementary schools work with this. To enable the purpose of the study to be maintained, a qualitative interview study became current. Seven semi-structured interviews with school counselors were conducted. The e
This study examines the influence of online ESG sentiment on credit market price movement in the banking sector. By employing a panel regression model with fixed effect for firms and time, the study’s findings indicate an inverse relationship between online ESG sentiment and CDS spread in accordance, to some extent, with previous literature. Additionally, the study investigates the impact througho
The primary objective of this investigation entailed examining the sexual knowledge, attitudes, and behaviors of young adults aged 18-29 who were enrolled at Lund University. Additionally, the study sought to determine whether a statistical relationship exists between knowledge, attitudes, and practices. Data collection employed a web-based survey method, sent out to a randomized sample of 1,000 s
The emergence of the refugee gang subculture has changed its focus from being a regional to a worldwide problem, drawing on the findings of previous studies. Many past studies suggest that the massive influx of Rohingya refugees from Myanmar has not only amplified existing socioeconomic challenges but has also fueled concerns within the host population in Bangladesh regarding organized gang violen
Tramways are a sustainable and accessible mode for public transport. They promote urban development and contribute to a more attractive city. Light rail, but also public transport as a whole, is an important part of society as it is accessible to everyone and reduces the amount of cars needed. The two tramlines in Norrköping account for two thirds of public transport travel in the city. The purpos
Narratives play a crucial role both in people’s lives and in various areas of the social, cultural and political realms. This thesis, drawing from an understanding of judicial sentences as a type of narrative, explores the complex domain of rape justice within the Spanish legal system. The aim is to discover the underpinning cultural meanings and constructions of rape in court sentences, by conduc
This study investigates the validity of the Permanent Income Hypothesis (PIH) across seven countries from 1970 to 2021. Using Hall's random-walk model and Campbell and Mankiw’s IV model, I investigate if the consumption patterns align with the implications of the PIH and if there are differences between the countries studied. The analysis suggests evidence against the PIH, revealing deviat
Recent decades have witnessed an innovation in genetics and biomedical practices, shifting the practice from treatment to prevention. Testing healthy individuals for genetic inherited diseases has now become increasingly common, preventing potential disease by offering early screenings, medication, or potentially surgery, reducing the genetic risk from developing into disease. Though, social scien
Extreme weather events, such as heatwaves and cold spells, are predicted to increase under climate change, which can have significant negative effects on fitness and survival of wildlife. If such variations are timed during development, they can affect growth and subsequent performance in birds, with influence over long-term temperature tolerance. Developmental temperature can also have direct eff
Sniffing out friends and foes: Bark beetle larvae and fungal scents. A tiny but destructive force is threatening Eurasian forest habitats – the Eurasian spruce bark beetle, Ips typographus. The larvae of this beetle species develop under the bark of conifers and feed on tree tissue. This leads to tree death and thus widespread devastation in wooded landscapes. The beetles live in partnership wit
Samverkande proteiner vid syrebrist under inflytande av inhibitorn PT2385 i hjärntumörceller från barn DIPG är en typ av hjärncancer hos barn som är placerad i övre delen av nacken vilket gör den svår att operera. Ledsamt nog finns ingen behandling för denna sjukdom, och patienter behandlas ofta med strålning för att förlänga livet med några enstaka månader. Hos den typiska patienten så överlevePurpose: The HIF-2α inhibitor PT2385 inhibits complex formation between HIF-2a and ARNT1 and thereby blocks HIF-2a transcriptional activation. It has been proven to extend survival in renal cancer, while its effects in pediatric brain cancer are unknown. This study is to investigate the effect of PT2385 in diffuse intrinsic pontine glioma (DIPG) cells, as well as to investigate HIF-2a interaction
Emotionellt arbete är ett begrepp som innebär den känsloreglering en individ gör för att leva upp till olika situationers förväntade beteenden och uttryck. Sker detta inom en yrkesroll så är det ett emotionellt lönearbete. Forskning har visat att denna känsloreglering, som innebär både att förstärka vissa känslor och förtrycka andra, kan vara skadligt för en individ som utövar detta under en längr
Investigating the Mechanism of Action of DNA Damage Response Inhibitors Cancer is a complex, heterogenous, systemic disease. It is considered to be a leading cause of death worldwide. Currently, there is limited treatment for this disease and the field of oncology presents the highest percentage of failed trials (32%) for drugs in phase II and phase III, mainly due to lack of efficacy or safety.
Glucose transporters, known as Gluts, play an important role in facilitating the transport of sugar across the cell membrane. Of these, 14 types are known, one of which is Glut3, which is highly expressed in the brain, testicles and nervous system. Its importance lies in the fact that it is responsible for the uptake of glucose in cells with high sugar requirements, such as neurons. Glucose uptake
Cracking the Code: Why Cancer Cells Struggle to Transform into Antigen-Presenting Dendritic Cells Since cancer is one of the leading causes of death worldwide, the possibility of converting cancer cells into other cell types represents an interesting approach to fighting cancer. Transforming cancer cells into immune cells by reprogramming their cell identity into immune cells could be a smart way
Rökextrakt och dess negativa påverkan på återvinningsprocesser i lungceller från KOL-patienter Kroniskt obstruktiv lungsjukdom (KOL) är en global folksjukdom och den tredje största dödsorsaken i världen. Den kan kopplas till en mängd andra sjukdomar och tillstånd som också ofta ökar risken för att utveckla KOL, t ex hög ålder, kardiovaskulära och neurosjukdomar. Men den största och mest välkända Chronic obstructive pulmonary disease (COPD) is the third largest cause of death worldwide, with its most prominent risk factor being inhalation of smoke and pollutants. In this project, we studied two processes that are involved in COPD: autophagy and cellular senescence. Using primary human bronchial epithelial cells (HBECs) from healthy and COPD donors, we aimed to show that cigarette smoke ext
Våra celler kommer ihåg SARS-CoV-2 Hjärt- och kärlsjukdomar är en av de ledande dödsorsakerna i världen. Ateroskleros, ett tillstånd där fett ansamlas i kärlen, har visats orsaka hjärt- och kärlsjukdomar. Flera delar av vårt immunförsvar har även visats ha ett samband med ateroskleros. En av dessa delar är det adaptiva immunförsvaret, där så kallade B- och T-celler finns. B- och T-celler ingår iAdaptive immunity has been implicated in cardiovascular diseases, but the relationship between immune capacity or immune function in these diseases has yet to be established. I optimized a method to screen for immune capacity using immune responsiveness against the SARS-CoV-2 spike protein as a proxy. This method screens for markers upregulated during activation on lymphocytes using fluorescent an
