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This study explored how propylene glycol (PG), menthol:thymol deep eutectic solvent (DES, molar ratio 6:4), and PG:DES blends modulate drug permeation by impacting the stratum corneum (SC). Porcine SC samples were exposed to PG, DES, and PG:DES blends with varying PG content (10 %, 50 %, or 90 %). The impact of these formulations on SC lipid extraction, lipid arrangement, and keratin's secondary s

Introduction: The climate and biodiversity crises are interconnected, unprecedented, existential threats that cause disturbing emotions, such as anxiety, grief, and anger. While there is increasing research about antecedents and outcomes of such eco-emotions, less is known about how to cope with them constructively, to benefit both mental health and pro-environmental action. Objectives: This study

Context. The bar pattern speed of the LMC has been computed based on data from Gaia DR3 using three different methods. One method suggested that the LMC might be hosting a bar that barely rotates, and is slightly counter-rotating with respect to the disc of the LMC, with a pattern speed of Ωp = −1.0 ± 0.5 km s−1 kpc−1. Aims. We aim to confirm that tidal interactions might prevent the bar hosted by

The Swedish Society of Paediatric Infectious Diseases worked with paediatric societies for emergency medicine, anaesthesia, and intensive care to produce the 2025 recommendations for the initial management of suspected sepsis. They cover 28 days of corrected age to 18 years, but exclude immunodeficiency, immunosuppression, and suspected meningitis. Suspicion of sepsis and sepsis-associated shock i

Indoleamine 2,3-dioxygenase 1 (IDO1) is the rate-limiting enzyme in tryptophan metabolism that plays a central role in immune regulation across a range of diseases, including cancer. Beyond its enzymatic role, IDO1 has a non-enzymatic function that remains poorly understood. This study explores how phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) modulates IDO1's structur

Objectives: Studies supporting therapeutic drug monitoring to biopharmaceuticals in SLE are scarce. We aimed to assess anti-drug antibody (ADA) occurrence in belimumab-treated SLE patients and associations between belimumab concentrations and clinical response, serological outcomes and adverse events. Methods. We included 100 patients treated with intravenous belimumab. Clinical data and biologica

Background: Bladder outlet obstruction, commonly resulting from benign prostatic hyperplasia or congenital urethral valves, is a prevalent cause of voiding dysfunction. This condition induces significant bladder hypertrophy, alters excitability, and increases residual urine. Obstruction has been extensively studied in experimental animal models using surgical obstruction. A frequent pathological e

Study region: Lake Vänern, the largest lake in the European Union, located in Sweden. Study focus: The study aimed to develop a spatially complete and temporally continuous lake surface water temperature (LSWT) dataset by fusing satellite remote sensing data with reanalysis products. Five satellite-derived LSWT products, including the Moderate Resolution Imaging Spectroradiometer (MODIS), were eva

The role of food disgust on entamophagy acceptance is well established but further indepth analysis of how food disgust impacts other aspects that include a wider range of attitudes have been seldom investigated. The study employed a two-study mixed-methods approach to determine the impact of food disgust on consumer's perceptions of insects as food and feed. In study one, an online questionnaire

Background: Nodal assessment in gallbladder cancer remains challenging, particularly in incidental gallbladder cancer. This understages the number of patients with node-positive disease, resulting in prognostic inaccuracy and insufficient adjuvant treatment. This study aimed to identify risk factors for positive nodes in gallbladder cancer and to compare prognostic discrimination of available noda

Background: Post-traumatic stress disorder (PTSD) is a significant psychiatric comorbidity in individuals with chronic pain. To date, the link between PTSD and chronic pain has mostly been described using the outdated DSM-IV PTSD criteria. Stronger evidence utilizing the updated DSM-5 criteria is needed to ensure comparability with earlier prevalence rates. Methods: This observational study report

This article shows that it is, in principle, possible to make a dielectric rod completely invisible to an incident electromagnetic plane wave of a given frequency. Students can derive the conditions that make the rod invisible if they understand the concept of plane waves, the boundary conditions for electric and magnetic fields, and the complex representation of electromagnetic fields. With acces

Background: The MEK-ERK1/2 and PKC pathways play critical roles in regulating functional changes in tissues, but their interplay remains poorly understood. The vasculature provides an ideal model to study these pathways, particularly under conditions of flow cessation, which is highly relevant to ischemia and other cardiovascular diseases. This study examined the independent roles, additive effect

Efforts to develop the wild berry industry in Sweden and internationally call for increased knowledge about the consumer perspective. Our objective is to investigate attitudes, product associations, consumption patterns, and foraging behaviour regarding bilberries, with an online survey using a nationally representative sample (N = 2010). The data were analysed with regression and multinomial test

Objective: Maintenance olaparib demonstrated clinical activity for progression-free survival in patients without a germline BRCA1 and/or BRCA2 mutation (non-gBRCAm) who had platinum-sensitive relapsed ovarian cancer in the phase IIIb, open-label, single-arm, non-comparator, international OPINION trial (NCT03402841). We report final overall survival (OS; secondary endpoint), prespecified secondary

In 2005, the Paediatric Radiation Oncology Society (PROS), a multi-professional association to promote radiotherapy for children and young people, was created. Its mission has been to educate those involved in this field, and to improve the standards of radiation oncology care for children, adolescents, and young adults across the globe, not least in less privileged settings where the majority of

The 19th Topical Meeting on Laser Applications to Chemical, Security, and Environmental Analysis (LACSEA) was held in Toulouse, France from 15–19 July 2024, as part of the Optica Optical Sensing Congress, with a return to in-person attendance. The meeting featured 21 sessions covering recent advances in laser and optical spectroscopy, sensor design, and diagnostic application. A total of 125 contr

TOI-1266 is a benchmark system of two temperate (<450 K) sub-Neptune-sized planets orbiting a nearby M dwarf exhibiting a rare inverted architecture with a larger interior planet. In this study, we characterize transit timing variations (TTVs) in the TOI-1266 system using high-precision ground-based follow-up and new TESS data. We confirm the presence of a third exterior nontransiting planet, TOI-

This paper argues that we have a moral obligation to implement certain health technologies even if we have limited or incomplete evidence of their effectiveness. The focus is on technologies used in non-emergency settings, as opposed to “exceptional cases” such as compassionate use and emergency approvals during public health emergencies. A broadly plausible moral principle – the Ecumenical Princi