Substance P, previously dismissed as a therapeutic target for migraine due to the failure of neurokinin-1 receptor antagonists, warrants renewed attention. Building on the success of therapies targeting the calcitonin gene-related peptide (CGRP) system and pituitary adenylate cyclase-activating peptide (PACAP) in migraine prevention, which highlight the importance of targeting peptides, this propo

Lipoproteins, key mediators of lipid transport, facilitate the bidirectional transfer of lipids such as fatty acids, triglycerides, and cholesterol between soluble particles and cell membranes. High-density lipoproteins (HDL) primarily engage in reverse cholesterol transport, while low-density lipoproteins (LDL) predominantly deposit lipids, affecting cardiovascular health with a well-known role i

Background: Cortical atrophy is a common manifestation in behavioral variant frontotemporal degeneration (bvFTD), exhibiting spatial heterogeneity across various genetic subgroups, which may be driven by distinct biological mechanisms. Methods: We employed an integrative imaging transcriptomics approach to identify both disparate and shared transcriptomic signatures associated with cortical thickn

The identity and source of flexible, semi-transparent, vascular-like components recovered from non-avian dinosaur bone are debated, because: (1) such preservation is not predicted by degradation models; (2) taphonomic mechanisms for this type of preservation are not well defined; and (3) although support for molecular endogeneity has been demonstrated in select specimens, comparable data are lacki

Bygg- och anläggningsindustrin har en betydande påverkan på Sveriges totala koldioxidutsläpp. För att uppnå FN:s globala mål krävs tydliga förändringar. Broar som byggs idag kräver mer material än broar som byggdes för 50 år sedan, trots att brotyperna är likadana. Tvärkraftsarmering i form av skjuvbyglar är något som konstruktörer generellt sett strävar efter att minimera av miljömässiga, arbetsmThe national construction and civil engineering industry contributes significantly to Sweden’s total carbon dioxide emissions. Meeting the United Nations’ global sustainability goals will require intelligible, measurable and structural changes within the industry. Notably, modern bridge designs often demand greater material use than those built half a century ago, albeit the structural types are f

As demand for nicotine pouches continues to grow globally, especially in the form of tobacco-free snus, efficient and scalable packaging solutions have become essential for producers. This report presents the design, development, and testing of a fully automated end-of-line packaging station using a collaborative robot (cobot), specifically the UR10e. The project was carried out in collaboration w

Foreign Object Debris (FOD) poses a serious threat to airport safety and efficiency, yet current detection processes often rely on manual labor, it is a repetitive task that is prone to human errors. This thesis investigates how a Human-Machine Interface (HMI) can be deigned to support the FOD detection and handling, with a specific focus on the needs and workflows of ground personnel in apron ope

This thesis compares how China and the European Union (EU) regulate the abuse of market dominance in the platform economy. As digital platforms increasingly shape economic activity, both jurisdictions face challenges in curbing anti-competitive practices by dominant firms. The central research question asks what the similarities and differences in their regulatory approaches reveal about their bro

This thesis examines the challenges faced by Chinese electric vehicle (EV) manufacturers in obtaining standard essential patent (SEP) licenses when entering the European market. It focuses on the SEP licensing framework within the European automotive industry, with particular attention to the Avanci patent pool and its representative licensing practices. By analyzing several Avanci-related cases i

Member States of the EU have authority to set up national tax systems in line with their national policies. While Member States maintain sovereignty over direct taxation, this power is constrained by EU law, including the State aid rules. National tax rulings can sometimes result in certain undertakings gaining advantages. The EU has rules regulating aid measures, to combat distortion of competiti

This paper addresses sustainability clauses in the European Union’s (EU) free trade agreements (FTAs) and examines their role in integrating environmental, social, and economic objectives within international trade. Against the backdrop of global sustainability agendas – namely Agenda 2030 and the European Green Deal – the study investigates how these contractual provisions are designed to support

This thesis examines which fiscal instruments are considered as Covered Taxes under the GloBE Model Rules particularly in the Oil and Gas sector. The countries used for the examination are Brazil and Nigeria as both have a huge oil and gas sector. While Brazil has adopted a Qualified Domestic Top-up Tax, Nigeria has abstained against the Pillar Two framework. The main research question explor

BACKGROUND: Previous studies of glucagon stimulation test (GST) in children have shown variable results regarding the utility and reliability of the cortisol response to this test and its correlation with clinical parameters. The aim of this study was to assess cortisol levels at GST and to evaluate how clinical parameters, such as age, sex, pubertal status and Body Mass Index (BMI), correlate to

Den globala uppvärmningen förändrar jordens klimat i snabb takt, det är främst utsläpp av växthusgaser som exempelvis koldioxid från förbränning av fossila bränslen som är orsaken. Sverige har tagit flera steg mot en hållbar energiproduktion där 65 % av elen är förnybar, men samtidigt är fossila bränslen en betydande del. Av Sveriges totala energianvändning går 25 % till att värma upp det befintliGlobal warming is changing the Earth's climate and is mainly caused by greenhouse gas emissions from, for example, fossil fuels. Sweden's energy production consists of 65 % renewable energy, but the remaining amount comes from fossil fuels. Of Sweden's total energy production, a quarter goes to heating existing buildings. Upcoming EU directives set higher requirements for energy effici

This thesis aims at understanding, through simulation, how the cosmic muon flux will look like in LDMX’s HCal and to use the characteristics of minimally ionizing muons to set up a method for scintillator bar calibration. LDMX’s HCal is a sampling calorimeter with scintillator bars as the active material. Cosmic muons enter the HCal from different angles, and thereby deposit different amounts of e

This thesis project, initiated by Thule, aimed to develop a concept for a foldable roof box. The goal was to create a solution that is easier to handle and store than traditional roof boxes, which are often perceived as bulky and difficult to manage when not in use. The project followed a design process based on the Double Diamond model, Human-Centered Design, and Thule’s internal development pro

The Japanese government's approval ratings are dropping fast ahead of elections in July

This paper investigates governance reform which aims to 'move the state' closer to people, arguing that greater attention needs to be paid to two questions: how does political decentralisation affect the ways in which authority is exercised? And what spaces does it leave open for poor people's agency? It focuses on West Bengal, an Indian innovator of decentralisation through panchayati raj ('rule