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Cathedral roofs are commonly used when constructing small houses in Sweden. In contrast to roof constructions with a cold attic, where frequent moisture damage has been noted, the cathedral roof is difficult to access for inspection. Furthermore, Swedish building regulations sets high demands regarding moisture safety, although there are no clear guidelines for their compliance. Hence, designing a
Conditions experienced early in development can affect the future performance of individuals and populations. Demographic theories predict persistent population impacts of past resources, but few studies have experimentally tested such carry-over effects across generations or cohorts. We used bumble bees to test whether resource timing had persistent effects on within-colony dynamics over sequenti
This work investigates the effectiveness of Collective intelligence (CI) in demand side management (DSM) in urban areas to cope with extreme climate events. CI is a form of distributed intelligence that emerges in collaborative problem solving and decision making. It is used in a simulation platform to control the energy performance of buildings in an urban area in Stockholm, through developing CI
Sexual dimorphism requires regulation of gene expression in developing organisms. These developmental differences are caused by differential expression of genes and isoforms. The effect of expressing a gene is also influenced by which other genes are simultaneously expressed (functional interactions). However, few studies have described how these processes change across development. We compare the
The specific effects of administering live probiotics in the human gut are not well characterized. To this end, we investigated the immediate effect of Lactobacillus rhamnosus GG (LGG) in the jejunum of 27 healthy volunteers 2 h after ingestion using a combination of global RNA sequencing of human biopsies and bacterial DNA sequencing in a multi-visit, randomized, cross-over design (ClinicalTrials
BACKGROUND: Larotrectinib is a first-in-class, highly selective tropomyosin receptor kinase (TRK) inhibitor approved to treat adult and pediatric patients with TRK fusion-positive cancer. The aim of this study was to evaluate the efficacy and safety of larotrectinib in patients with TRK fusion-positive primary central nervous system (CNS) tumors.METHODS: Patients with TRK fusion-positive primary C
Open Government Data (OGD) is an important driver for open innovation among public entities. However, extant research highlights a need for improved feedback loops, collaboration, and a more demand-driven publication of OGD. In this study, we explore how public platform providers can address this issue by enabling collaboration within OGD ecosystems, both in terms of the OGD, and any related Open
Riktlinjer för Kungl. Konsthögskolans grafiska formgivning beskrivs i skriften Mellan sköldebrev och varumärkesmanual. Skriften är främst riktad till dig som arbetar med högskolans grafiska formgivning och kommunikation, men även till dig som har annan anknytning till verksamheten eller är intresserad av konstnärliga högskolors kommunikation med omvärlden.
We present a fully relational definition of inertial systems based in the No Arbitrariness Principle, that eliminates the need for absolute inertial frames of reference or distinguished reference systems as the ``fixed stars'' in order to formulate Newtonian mechanics. The historical roots of this approach to mechanics are discussed as well. The work is based in part in the constructivist perspect
Heart failure (HF) is among the main causes of death worldwide. Alterations of sphingosine-1-phosphate (S1P) signaling have been linked to HF as well as to target organ damage that is often associated with HF. S1P's availability is controlled by the cystic fibrosis transmembrane regulator (CFTR), which acts as a critical bottleneck for intracellular S1P degradation. HF induces CFTR downregulation
Objectives: The augmented inflammatory response to cardiac surgery is a recognized cause of postoperative acute kidney injury. The present study aimed to investigate the effects of preoperative cyclosporine treatment on cytokine production and delineate factors associated with postoperative kidney impairment. Design: A randomized, double-blind, placebo-controlled, single-center study. Setting: At
