The ninetieth birthday of the last surviving founding father of post-WWII classical music is certainly reason enough for celebration, but what could the Lucerne Festival offer that has not already been covered by the many festivities that have taken place around the world? Fortunately, the festival has a trump card up its sleeve: the Lucerne Festival Academy, founded 11 years ago by Pierre Boulez

An atmosphere of sadness, anger and uncertainty dominated this year's Donaueschinger Musiktage. The passing in November 2014 of Armin Köhler, the artistic driving force behind the festival for the last 23 years, has left a hole that will be hard to fill. Meanwhile, due to state budget cuts Donaueschingen's orchestra-in-residence, the SWR Sinfonieorchester Freiburg und Baden-Baden, paid what will a

Creating a work today that claims to be encyclopedic is a daunting task. In the age of instant access to online resources and the pervasive reach of Wikipedia, what purpose can an old-fashioned encyclopedia seek to fulfil? In the case of The Cambridge Encyclopedia of Brass Instruments (part of an ongoing series of musical encyclopedias from CUP), the answer is evident after any casual conversation

Through his orchestral experimentation with acoustics and timbre, Richard Wagner is credited with conceptualizing, commissioning, and attempting to integrate several new labrosones into the orchestra. To greater or lesser extents, they all eventually failed to enter mainstream performance practice, but with one notable exception. Today, the contrabass tuba is a compulsory instrument for profession

This paper proposes an examination of the intersections of materiality, acoustics, and musical performance practice through the prism of instruments of the tuba family.[*] Investigation into the symbiotic relationship between instrumental evolution and performance practice is a crucial facet of any study of timbre and orchestration. The development of musical objects to produce the sound colors de

This chapter assess the state of brass instruments and their associated repertoire and performance practices in the early twenty-first century. Technological innovations and manufacturing developments from recent decades are outlined, as well an examination of how performance techniques have evolved and adapted to meet the demands of modern musicians. Finally, an overview is given of contemporary

Three quarters of all breast cancers express the estrogen receptor (ER, ESR1 gene), which promotes tumor growth and constitutes a direct target for endocrine therapies. ESR1 mutations have been implicated in therapy resistance in metastatic breast cancer, in particular to aromatase inhibitors. ESR1 mutations promote constitutive ER activity and affect other signaling pathways, allowing cancer cell

Bacterial or viral antigens can contain subdominant protein regions that elicit weak antibody responses upon vaccination or infection although there is accumulating evidence that antibody responses against subdominant regions can enhance the protective immune response. One proposed mechanism for subdominant protein regions is binding of host proteins that prevent antibody production against epitop

OBJECTIVE: To examine the prevalence and predictive factors for celiac disease (CD) after a diagnosis of type 1 diabetes (T1D) in children and adolescents, to improve the current screening guidelines.RESEARCH DESIGN AND METHODS: The association between sex, age at T1D diagnosis, HLA, and diabetes autoantibodies, and a diagnosis of CD was examined in 5,295 children with T1D from the Better Diabetes

Photoredox properties of several earth-abundant light-harvesting transition metal complexes in combination with cobalt-based proton reduction catalysts have been investigated computationally to assess the fundamental viability of different photocatalytic systems of current experimental interest. Density functional theory (DFT) and time-dependent DFT (TD-DFT) calculations using several GGA (BP86, B

Purpose: This paper aims to focus on academic library managers’ learning practices in the context of cooperative work supported by computational artefacts. Academic library managers’ everyday work is mainly cooperative. Their cooperation is supported predominantly by computational artefacts. Learning how to use the computational artefacts efficiently and effectively involves understanding the chan

Aims: To determine the magnitude of the association between abdominal adiposity and low-grade inflammation in persons with recently diagnosed type 2 diabetes (T2D) and to determine to what extent this association is mediated by low physical activity level, hyperinsulinaemia, hyperglycaemia, dyslipidaemia, hypertension, and comorbidities. Materials and Methods: We measured waist circumference, clin

Objective: To determine the diagnostic accuracy of prenatal ultrasound in detecting coarctation of the aorta (CoA). Methods: An individual participant data meta-analysis was performed to report on the strength of association and diagnostic accuracy of different ultrasound signs in detecting CoA prenatally. MEDLINE, EMBASE and CINAHL were searched for studies published between January 2000 and Nove

Animal migration has fascinated scientists and the public alike for centuries, yet migratory animals are facing diverse threats that could lead to their demise. The Anthropocene is characterised by the reality that humans are the dominant force on Earth, having manifold negative effects on biodiversity and ecosystem function. Considerable research focus has been given to assessing anthropogenic im