Parkinson's disease (PD) is an age-related chronic neurological disorder, mainly characterized by the pathological feature of α-synuclein (α-syn) aggregation, with the exact disease pathogenesis unclear. During the onset and progression of PD, synaptic dysfunction, including dysregulation of axonal transport, impaired exocytosis, and endocytosis are identified as crucial events of PD pathogenesis.

To make glomerular filtration rate (GFR) estimating equations applicable across populations with different creatinine generation by using rescaled serum creatinine (sCr/Q) where sCr represents the individual creatinine level and Q the average creatinine value in healthy persons of the same population. GFR measurements (mGFR, plasma clearance of 51Cr-EDTA) were conducted in 964 adult Black European

Introduction: Carbon monoxide (CO) is a colorless and odorless gas that is a leading cause of environmental poisoning in the USA with substantial mortality and morbidity. The mechanism of CO poisoning is complex and includes hypoxia, inflammation, and leukocyte sequestration in brain microvessel segments leading to increased reactive oxygen species. Another important pathway is the effects of CO o

Background: Adverse childhood experiences (ACE) can have negative effects on cognitive, social and emotion regulation abilities, which can threaten the child’s school integration and capacity to learn. While steady relations to sensitive, understanding adults may moderate these negative outcomes, the difficulties of children with ACEs pose a major challenge for teachers, whose insufficient prepara

Asymmetry. What is in the word? One kind of asymmetry is asymmetrical coaction, that is, when actors relate in different ways to one another and/or partake differently in an action done together. Coaction requires that the actors acting together, during the process, reach an enlarged mentality (Arendt, Lectures on Kant’s Political Philosophy), either through putting themselves in the position of o

The subfamily Nossidiinae was established in 2019 and is comprised of five genera including one fossil genus. Among them, Nossidium Erichson and Sindosium Johnson share many morphological similarities. To this point, two extant Nossidium-species, N. flachi Ganglbauer and N. pilosellum (Marsham) have been recorded in the Palaearctic realm. In this paper, we describe three new species, Nossidium kor

Carbon materials with unique sp2-hybridization are extensively researched for catalytic applications due to their excellent conductivity and tunable physicochemical properties. However, the development of economic approaches to tailoring carbon materials into desired morphologies remains a challenge. Herein, a convenient “bottom-up” strategy by pyrolysis of graphitic carbon nitride (g-C3N4) (or ot

In the 1920s and 30s, a criminal investigation followed by a trial against a group of allegedly homosexual men was launched in Gothenburg, Sweden. Almost a century later, Swedish artist Conny Karlsson Lundgren engages with these events in a multifaceted two-part installation and performative work that borrows the title from the investigation, The Gothenburg Affair (Göteborgsaffären). In this artic

This paper addresses the comorbidity of substance use and mental illness among women in Iran and the barriers they encounter in accessing treatment. Research has demonstrated a higher prevalence of comorbidity of substance use disorders and mental illness among women than men. It has been suggested that women in Iran may face numerous barriers to appropriate care, such as stigma and discrimination

In healthcare, data privacy of patients regulations prohibits data from being moved outside the hospital, preventing international medical datasets from being centralized for AI training. Federated learning (FL) is a data privacy-focused method that trains a global model by aggregating local models from hospitals. Existing FL techniques adopt a central server-based network topology, where the serv

Has Visual International Relations (IR) become too distant from the content of visual artefacts? This is a paradoxical question. Visual IR is a vibrant and pluralist field exploring visuals in innumerable ways. Nonetheless, the field tends to focus on 'deep' readings of the socio-political implications of visual artefacts at the expense of a close and attentive observation and description of the e

A test of CP invariance in Higgs boson production via vector-boson fusion has been performed in the H→γγ channel using 139 fb^{-1} of proton-proton collision data at sqrt[s]=13 TeV collected by the ATLAS detector at the LHC. The optimal observable method is used to probe the CP structure of interactions between the Higgs boson and electroweak gauge bosons, as described by an effective field theory

A search for pair-produced vector-like quarks using events with exactly one lepton (e or μ), at least four jets including at least one b-tagged jet, and large missing transverse momentum is presented. Data from proton–proton collisions at a centre-of-mass energy of s= 13 TeV , recorded by the ATLAS detector at the LHC from 2015 to 2018 and corresponding to an integrated luminosity of 139 fb - 1 ,

A search for a long-lived, heavy neutral lepton (N) in 139 fb^{-1} of sqrt[s]=13 TeV pp collision data collected by the ATLAS detector at the Large Hadron Collider is reported. The N is produced via W→Nμ or W→Ne and decays into two charged leptons and a neutrino, forming a displaced vertex. The N mass is used to discriminate between signal and background. No signal is observed, and limits are set

New synthetic hybrid materials and their increasing complexity have placed growing demands on crystal growth for single-crystal X-ray diffraction analysis. Unfortunately, not all chemical systems are conducive to the isolation of single crystals for traditional characterization. Here, small-molecule serial femtosecond crystallography (smSFX) at atomic resolution (0.833 Å) is employed to characteri

We investigate whether pure entangled states can be associated to a measurement basis in which all vectors are local unitary transformations of the original state. We prove that for bipartite states with a local dimension that is either 2, 4, or 8, every state corresponds to a basis. Via numerics, we strongly evidence the same conclusion for two qutrits and three qubits also. However, for some sta

A measurement of the charge asymmetry in top-quark pair (tt¯) production in association with a photon is presented. The measurement is performed in the single-lepton tt¯ decay channel using proton–proton collision data collected with the ATLAS detector at the Large Hadron Collider at CERN at a centre-of-mass-energy of 13 TeV during the years 2015–2018, corresponding to an integrated luminosity of