Uncontrolled asthmatics have increased FceRI+ and TGF-β–positive MCTC mast cells and collagen VI in the alveolar parenchyma
Background: Asthma has been associated with increased collagen deposition in both conducting airways and alveolar parenchyma. Mast cells (MCs) are key effector cells in asthma and have the ability to affect collagen synthesis. However, the link between clinical control and changes in bronchial and alveolar MC phenotypes and specific collagens in controlled and uncontrolled asthma remains unknown.