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Improved soil hydrological modeling with the implementation of salt-induced freezing point depression in CoupModel : Model calibration and validation

Soil freezing/thawing is an important mechanism to control soil water and heat redistribution in mid-to-high latitudes. Salt in the agricultural soil from mid-to-high latitudes can alter characteristics of soil freezing/thawing cycle and then affect soil thermal and hydrological processes in winter and finally cause salinization in spring. To quantify the impacts of soil salinization on soil water

Low-dose in situ prelocation of protein microcrystals by 2D X-ray phase-contrast imaging for serial crystallography

Serial protein crystallography has emerged as a powerful method of data collection on small crystals from challenging targets, such as membrane proteins. Multiple microcrystals need to be located on large and often flat mounts while exposing them to an X-ray dose that is as low as possible. A crystal-prelocation method is demonstrated here using low-dose 2D full-field propagation-based X-ray phase

High-dose naloxone : Effects by late administration on pain and hyperalgesia following a human heat injury model. A randomized, double-blind, placebo-controlled, crossover trial with an enriched enrollment design

Severe chronic postsurgical pain has a prevalence of 4–10% in the surgical population. The underlying nociceptive mechanisms have not been well characterized. Following the late resolution phase of an inflammatory injury, high-dose μ-opioid-receptor inverse agonists reinstate hypersensitivity to nociceptive stimuli. This unmasking of latent pain sensitization has been a consistent finding in roden

Validation of prostate cancer risk variants rs10993994 and rs7098889 by CRISPR/Cas9 mediated genome editing

GWAS have identified numerous SNPs associated with prostate cancer risk. One such SNP is rs10993994. It is located in the β-microseminoprotein (MSMB) promoter region, mediates MSMB prostate secretion levels, and is linked to mRNA expression changes in both MSMB and the adjacent gene NCOA4. In addition, our previous work showed a second SNP, rs7098889, is in positive linkage disequilibrium with rs1

Risk of colorectal cancer in patients with diabetes mellitus : A Swedish nationwide cohort study

BACKGROUND: Colorectal cancer (CRC) incidence is increasing among young adults below screening age, despite the effectiveness of screening in older populations. Individuals with diabetes mellitus are at increased risk of early-onset CRC. We aimed to determine how many years earlier than the general population patients with diabetes with/without family history of CRC reach the threshold risk at whi

The Health of Older Family Caregivers–A 6-Year Follow-up

It is unclear whether caregiving has an impact on the physical, mental and functional health of older caregivers. This study aimed to describe physical, mental and functional health in relation to family caregiving in old age (60+) over a six-year period. The study comprised 2,294 randomly selected individuals (60–96 years) from the Swedish National Study on Aging and Care, who answered the questi

Review of wildfire indices : Indices applicable for a Swedish context

Wildfire risk indices can be used in order to be better prepared for wildfires. In Sweden, the Canadian Fire Weather Index (FWI) is currently used to predict fire behaviour based on meteorological data such as wind velocity, temperature and rainfall. Additionally, the HBV model, used to calculate moisture content in soil layers, serves to predict the ignition risk in Sweden. There are however many

Regional inhaled deposited dose of indoor combustion-generated aerosols in jordanian urban homes

Indoor combustion processes associated with cooking, heating, and smoking are a major source of aerosols in Jordanian dwellings. To evaluate human exposure to combustion-generated aerosols in Jordanian indoor environments, regional inhaled deposited dose rates of indoor aerosols (10 nm to 25 µm) were determined for different scenarios for adult occupants. The inhaled deposited dose rate provides a

Evaluation of competence in ultrasound-guided procedures—a generic assessment tool developed through the Delphi method

Objectives: To develop a generic and objective tool for assessing competence in percutaneous ultrasound-guided procedures. Methods: Interventional ultrasound experts from the Nordic countries were invited to participate in a three-round Delphi process. A steering committee was formed to manage the process. In round 1, the experts were asked to suggest all aspects to consider when assessing compete

Review of flooding indices : Indices applicable for a Swedish context

Flood risk indices and methods (such as flood risk maps) can be used for long-term pro-active activities like urban planning to reduce flooding risk but also for short-term action such as issuing early warnings when hydro-meteorological conditions are expected to develop in a way that could lead to flooding. There are many different flood risk indices and methods used in the world and this study a

On the discovery of new elements (IUPAC/IUPAP Report) : Report of the 2017 Joint Working Group of IUPAC and IUPAP

Almost thirty years ago the criteria that are currently used to verify claims for the discovery of a new element were set down by the comprehensive work of a Transfermium Working Group, TWG, jointly established by IUPAC and IUPAP. The recent completion of the naming of the 118 elements in the first seven periods of the Periodic Table of the Elements was considered as an opportunity for a review of

Impact of baseline COPD symptom severity on the benefit from dual versus mono-bronchodilators : an analysis of the EMAX randomised controlled trial

Rationale: Symptom relief is a key treatment goal in patients with chronic obstructive pulmonary disease (COPD). However, there are limited data available on the response to bronchodilator therapy in patients at low risk of exacerbations with different levels of symptom severity. This study compared treatment responses in patients with a range of symptom severities as indicated by baseline COPD as

Similar early mortality risk after cemented compared with cementless total hip arthroplasty for primary osteoarthritis : data from 188,606 surgeries in the Nordic Arthroplasty Register Association database

Background and purpose — Current literature indicates no difference in 90-day mortality after cemented compared with cementless total hip arthroplasty (THA). However, previous studies are hampered by potential selection bias and suboptimal adjustment for comorbidity confounding. Therefore, we examined the comorbidity-adjusted mortality up to 90 days after cemented compared with cementless THA perf

The Effectiveness of Evacuation Alarms in Multi-Hazard Environments

The aim of this thesis is to investigate the effectiveness of using specific alarms for each hazardversus the effectiveness of using a single alarm for all hazards in multi-hazard facilities. Theresearch was conducted by disseminating online questionnaires containing audio files of differentalarms to occupants of multi-hazards facilities and conducting interviews with safety expertsworking at mult

Energy inequality as a risk in socio-technical energy transitions : The Swedish case of individual metering and billing of energy for heating

Improved energy efficiency in the housing stock is an important undertaking in the energy transition but is associated with both opportunities and risks. While there are possibilities to reduce energy inequalities in the housing stock, inequalities also risk being aggravated as actions for energy efficiency usually aim at the least energy efficient—and thus sometimes the least privileged—parts of Improved energy efficiency in the housing stock is an important undertaking in the energy transition but is associated with both opportunities and risks. While there are possibilities to reduce energy inequalities in the housing stock, inequalities also risk being aggravated as actions for energy efficiency usually aim at the least energy efficient—and thus sometimes the least privileged—parts of

Association between fixation type and revision risk in total knee arthroplasty patients aged 65 years and older : a cohort study of 265,877 patients from the Nordic Arthroplasty Register Association 2000–2016

Background and purpose — The population of the Nordic countries is aging and the number of elderly patients undergoing total knee arthroplasty (TKA) is also expected to increase. Reliable fixation methods are essential to avoid revisions. We compared the survival of different TKA fixation concepts with cemented fixation as the gold standard. Patients and methods — We used data from the Nordic Arth

QCD challenges from pp to A–A collisions

This paper is a write-up of the ideas that were presented, developed and discussed at the third International Workshop on QCD Challenges from pp to A–A, which took place in August 2019 in Lund, Sweden (Workshop link: https://indico.lucas.lu.se/event/1214/). The goal of the workshop was to focus on some of the open questions in the field and try to come up with concrete suggestions for how to make

Precipitating factors of heart failure decompensation, short-term morbidity and mortality in patients attended in primary care

Objective: To evaluate the precipitating factors for heart failure decompensation in primary care and associations with short-term prognosis. Design Prospective cohort study with a 30-d follow-up from an index consultation. Regression models to determine independent factors associated with hospitalisation or death. Setting: Primary care in ten European countries. Patients Patients with diagnosis o

A probabilistic-deterministic analysis of human health risk related to the exposure to potentially toxic elements in groundwater of Urmia coastal aquifer (NW of Iran) with a special focus on arsenic speciation and temporal variation

The human exposure to groundwater contamination with toxic elements is a worldwide concern. In this study, multivariate statistics coupled with probabilistic and deterministic risk estimation approaches were applied to 173 groundwater samples of Urmia aquifer (UA) to evaluate human health risks in relation to the consumption of groundwater contaminated with toxic elements. The concentrations of al