We have previously demonstrated that the intracellular, non-GPI anchored CD59 isoforms IRIS-1 and IRIS-2 (Isoforms Rescuing Insulin Secretion 1 and 2) are necessary for insulin secretion from pancreatic β-cells. While investigating their expression across human tissues, we identified IRIS-1 and IRIS-2 mRNA in the human brain, though their protein expression and function remained unclear. This stud

Exposure to diesel exhaust is associated with increased risk of cardiovascular and lung disease. Substituting petroleum diesel with renewable diesel can alter emission properties but the potential health effects remain unclear. This study aimed to explore toxicity and underlying mechanisms of diesel exhaust from renewable fuels. Using proximity extension assay (Olink), 92 proteins linked to inflam

Background: Positron emission tomography/computed tomography (PET/CT) with prostate specific membrane antigen ligands (PSMA) is established for use in primary staging of prostate cancer to screen for metastases. It has also shown promise in local tumor staging, including detection of extraprostatic extension (EPE) and seminal vesicle invasion (SVI). Previous studies have shown high heterogeneity i

Objectives To investigate the effect of precarious employment (PE) on the risk of diagnosed chronic musculoskeletal disorders (MSDs) among Swedish workers in occupations with strenuous working conditions. Methods This nationwide register-based cohort study included workers registered as living in Sweden in 2005, aged 21-60 at the 2010 baseline. Three samples were included: workers with high biomec

Research shows conversations matter - both for learning and inspiring action. In this podcast collection, we are 'Talking Transformations' with thought leaders from government, industry, and academia. Our mission is to discuss current trends in science, technology, governance, and behaviours to transform our society and economy towards sustainability. In this podcast mini-series, season 2, we talk

This paper considers the ways in which research projects linger beyond their ‘official’ endings, and how to deal with this. Building on conversations in human geography and related disciplines on slow research, performed endings, and the practical and socio-political complexities of data storage and analysis over time, I relate some experiences with my research on the Finnish Saimaa Ringed Seal, w

Pathogenic variants in KIAA0586/TALPID3 are associated with the ciliopathy Joubert syndrome (JS). We report individuals with KIAA0586/TALPID3 variants affected by primary and motile cilia defects leading to JS and chronic destructive airway disease. DNA variants were detected in three families by sequencing. In two unrelated families, a deep-intronic variant (KIAA0586/TALPID3:c.3990 + 3186G>A) act

Aim: To analyse the challenges faced by parents of extremely preterm infants born before 24 weeks of gestation and the potential buffering effect of perceived resources on the family's health continuum. Methods: The qualitative data were obtained from 70 parents of 70 infants born before 24 weeks of gestation, through open-ended questions in a survey. An inductive content analysis was conducted to

Raw sediment samples which are without prior lengthy laboratory preparation can be used to obtain a rough but rapid estimate of the luminescence equivalent dose, and thus of the relative age of the sediment. In this study, we tested this range-finder method on clastic sediments in NE Poland for the first time, with special focus on Pleistocene meltwater sediments generated by highly energetic glac

Ne Zha has successfully created both an emotional and patriotic bond with Chinese audiences while boosting China's cultural confidence.

We reconcile dense and sparse modelling by exploiting the positive aspects of both. We employ a high-dimensional, approximate static factor model and assume the idiosyncratic term follows a sparse vector autoregressive model (VAR). The estimation is articulated in two steps: (i) factors and loadings are estimated via principal component analysis (PCA); (ii) a sparse VAR is estimated via the lasso

Our food and land-use systems are critical for staying within our planetary boundaries and the Earth’s system resilience. Among the six Transformations required to achieve the Sustainable Development Goals (SDGs), the fourth Transformation—focusing on food, land, and water—is crucial. This Transformation is key to achieving SDG 2 (Zero Hunger), SDG 6 (Clean Water and Sanitation), SDG 12 (Responsib

Research question: Do directed oocyte donors differ from non-directed identity-release oocyte donors regarding pre-donation motives and ambivalence, and post-donation satisfaction and openness? Design: The study is part of the longitudinal Swedish Study on Gamete Donation where consecutive samples of identity-release gamete donors at seven Swedish University Hospitals were approached during a 3-ye

Regardless of our socio-juridical position in or outside of organisations, this much is certain: even if not formally employed, we all, Agamben’s Homo Sacer series and the bulk of his other texts imply, are subject to a violence that, if differentially, imprisons us in a world in which ‘work’ reigns supreme. But what precisely is ‘work’? And is there, in spite of our securing the necessities of liRegardless of our socio-juridical position in or outside of organisations, this much is certain: even if not formally employed, we all, Agamben’s Homo Sacer series and the bulk of his other texts imply, are subject to a violence that, if differentially, imprisons us in a world in which ‘work’ reigns supreme. But what precisely is ‘work’? And is there, in spite of our securing the necessities of li

Gamma-aminobutyric acid (GABA) is known for its multiple physiological functions, including beneficial effects against several metabolic disorders. This study explores enzymatic strategies to enhance the functional value of Andean seeds, specifically tarwi (Lupinus mutabilis), cañihua (Chenopodium pallidicaule) and quinoa (Chenopodium quinoa) real varieties, by converting their naturally occurring

PURPOSE: Four-pool Voigt (FPV) machine learning (ML)-based fitting for Z-spectra was developed to reduce fitting times for clinical feasibility in terms of on-scanner analysis and to promote larger cohort studies. The approach was compared to four-pool Lorentzian (FPL)-ML-based modeling to empirically verify the advantage of Voigt models for Z-spectra.METHODS: Voigt and Lorentzian models were fitt

Nature-based solutions, such as urban green spaces, are shown to contribute to carbon emissions reduction and carbon sequestration, and also to have valuable indirect effects and behavioural impacts. Implementing such solutions could achieve carbon neutrality within the decade in several major cities in Europe.

Adapting successes of policy transition from one city to another has been more difficult than single case of successful sustainability-driven projects and developments. A thorough understanding of local biophysical and socio-economic conditions is essential in formulating effective development plans and policies. Here, we propose the use of a social-ecological model as a comparative tool to help u