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High-risk neuroblastoma (NB) is a significant clinical challenge. MYCN and Anaplastic Lymphoma Kinase (ALK), which are often involved in high-risk NB, lead to increased replication stress in cancer cells, suggesting therapeutic strategies. We previously identified an ATR (ataxia telangiectasia and Rad3-related)/ALK inhibitor (ATRi/ALKi) combination as such a strategy in two independent genetically

BACKGROUND: Lactiplantibacillus plantarum HEAL9 and Lacticaseibacillus paracasei 8700:2 positively affect the fecal bacteriome in children with celiac disease autoimmunity after 6 months of supplementation. The aim of the present investigation was to study the effects of Lactiplantibacillus plantarum HEAL9 and Lacticaseibacillus paracasei 8700:2 on the single-cell parasitome, with a primary focus

High-density lipoproteins (HDLs) are promising targets for predicting and treating atherosclerotic cardiovascular disease (ASCVD), as they mediate removal of excess cholesterol from lipid-laden macrophages that accumulate in the vasculature. This functional property of HDLs, termed cholesterol efflux capacity (CEC), is inversely associated with ASCVD. HDLs are compositionally diverse, associating

This article investigates the media lives of a particular class taxonomy in the Swedish press from 1945 to 1976. Invented by the Central Bureau of Statistics in 1911, the ‘social group division’ system was abandoned in the early post-war period. Around the same time, however, it gained popularity in Swedish culture and political debate. While earlier research has noted that such bureaucratic class

A new rotational coherent anti-Stokes Raman spectroscopy (RCARS) concept based on interferometric quantum control (IQC) is demonstrated. Two wavepackets originating from pure rotational states are created by a femtosecond stimulated rotational Raman interaction. The two Raman responses are instantly probed by a single-mode ns pulse generating two interfering RCARS polarizations. The resulting sign

Deterrence and resilience are intimately connected. Deterrence is about understanding threats and using levers that might force an adversary to reconsider their objectives and actions against you. Resilience is about understanding yourself and the measures you can take to become a less attractive target, or to bounce back more quickly from a setback. This combination of deterrence and resilience h

The deteriorating security environment in Europe due to the increasing conflict of interests between western democracies and Russia is now, after the Russian invasion of Ukraine, obvious to all. But the willingness of the Russian state to oppose and disrupt European security order and the sovereignty of other states is not new. One increasingly common way is using influence operations, often in co

Current food systems pose one of the greatest health and environmental challenges of the 21st century. Expanded utilization of seaweed for food in Western societies seems like one promising measure in the transition toward sustainable food systems. However, introducing and expanding seaweed to new markets brings certain challenges, such as limited food acceptance and availability. In this pilot coCurrent food systems pose one of the greatest health and environmental challenges of the 21st century. Expanded utilization of seaweed for food in Western societies seems like one promising measure in the transition toward sustainable food systems. However, introducing and expanding seaweed to new markets brings certain challenges, such as limited food acceptance and availability. In this pilot co

The authors take on a problem that many departments in Sweden, not least in the humanities, are dealing with right now: language. They show how social status in academia is decoupled from linguistic integration, at least if we understand status in terms of academic titles. Feelings of insufficiency and incompleteness are, however, prevalent, even among those whose Swedish proficiency is objectivel

PURPOSE: This project aimed to launch an international learning community to guide the development of a spina bifida (SB) curriculum for global health trainees.METHODS: Using a descriptive study design, a convenience sample of SB curricula were identified in 2022-23 by members of the Spina Bifida World Congress Outreach Committee and evaluated during a series of monthly Zoom calls to discuss SB ed

There is limited understanding of how education initiatives geared toward faculty and support staff can foster a capacity for long-term and integrated societal engagement and collaboration within higher education institutions. Using the experiences from a cross-disciplinary pilot course in Sweden, the current study aims to identify features that explicate how skills and academic rigor for engagingThere is limited understanding of how education initiatives geared toward faculty and support staff can foster a capacity for long-term and integrated societal engagement and collaboration within higher education institutions. Using the experiences from a cross-disciplinary pilot course in Sweden, the current study aims to identify features that explicate how skills and academic rigor for engaging

The demand for user participation in design processes is increasing, and there is a need to formulate guidance on how to involve disabled users and their representative organisations. Their participation contributes an extreme user perspective to the design process. The aim of this study was to develop an empirically grounded framework for user participation in co-design processes, involving the u

Background: Artificial intelligence (AI) systems are proposed as a replacement of the first reader in double reading within mammography screening. We aimed to assess cancer detection accuracy of an AI system in a Danish screening population. Methods: We retrieved a consecutive screening cohort from the Region of Southern Denmark including all participating women between Aug 4, 2014, and August 15,

Formants (vocal tract resonances) are increasingly analyzed not only by phoneticians in speech but also by behavioral scientists studying diverse phenomena such as acoustic size exaggeration and articulatory abilities of non-human animals. This often involves estimating vocal tract length acoustically and producing scale-invariant representations of formant patterns. We present a theoretical frame

Med utgångspunkt i historiska och empiriska beskrivningar av offentliga och privata badanläggningar i Japan undersöker denna artikel kulturella betydelser i japanska badvanor. Genom att undersöka nakenhet och varmt vatten som förmedlare av närhet och intim socialitet i Japan, utmanar artikeln gränserna mellan den privata och offentliga sfären och det intima och sociala. Artikeln visar att badvanorBased on historical and empirical descriptions of bathing practice in public bath-houses and private bathing facilities in Japan, this article examines cultural meanings embedded in Japanese bathing practice. The article explores the relation between Japanese bathing practice and notions of the private and the public spheres as well as intimacy and sociality. By studying naked skin and hot water a

The photophysics of layered halide perovskites reveals a rich disposition of exciton behavior. Two-dimensional electronic spectroscopy (2DES) is a powerful technique for investigating such excitonic interactions and dynamics. However, the wide spectral range of layered perovskites presents a challenge in studies utilizing conventional 2DES setups to simultaneously probe their interacting excitonic

This keynote presentation explores the transformative potential of digital technologies, with a specific focus on the Internet of Things (IoT), in revolutionizing food production for a more sustainable and efficient future. It delves into the critical issue of solid food waste and how digitization, through IoT, provides valuable insights to curtail waste and enhance resource efficiency in food man