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Neutrophils play a crucial role in host defense. However, neutrophil activation is also linked to autoimmune diseases such as systemic lupus erythematosus (SLE), where nucleic acid-containing immune complexes (IC) drive inflammation. The role of Toll-like receptor (TLR) signaling in processing of SLE ICs and downstream inflammatory neutrophil effector functions is not known. We observed that TLR7/
Abiotrophia defectiva is a well-known endocarditis pathogen, however it has never been described as a cause of primary aortitis. Here we describe the first published case of thoracic aortitis and an unusual case of aortic graft infection due to A. defectiva, which were both managed conservatively.
Suppose that a circular fire spreads in the plane at unit speed. A single fire fighter can build a barrier at speed v>1. How large must v be to ensure that the fire can be contained, and how should the fire fighter proceed? We contribute two results. First, we analyze the natural curve FFv that develops when the fighter keeps building, at speed v, a barrier along the boundary of the expanding fir
An improved method, where conventional otoscope investigation of human suspicious otitis media is combined with diffuse reflectance spectroscopy and gas in scattering media absorption spectroscopy (GASMAS) is being developed. Otitis media is one of the most common infectious diseases in children, whose Eustachian tube connecting the middle ear with the nasal cavity is more horizontal than for adul
Despite the high degree of complexity that marks the migratory flows transiting the country they have historically been perceived as labour and voluntary migrations and used in the production of “illegality”. “Illegality” demarcates and ‘invisibilises’ individuals eligible for protection. Incidents such as death, rape, kidnappings and other types of abuse faced by transit migratory flows across bo
Radiological and pathological characteristics of hip osteoarthritis (OA) is joint-space loss due to degradation of articular cartilage. However, patients with early-stage OA do not yet show any radiological signs, which leaves them without diagnosis and treatment. This study evaluates the potential of a novel tool to identify pre-radiographic OA changes based on hip bone morphology. Two statistica
This paper focuses on the spatial distribution of bone tool production waste from two Mesolithic sites in Sweden, Ringsjöholm and Strandvägen, with well-preserved faunal remains including bone and antler artifacts. Local production on both sites has generated a variety of identifiable waste products deriving from complete chains of production, including unmodified bones, debitage and finished prod
In order to achieve a consistent level of failure probability, structural design codes are optimized using probabilistic methods. This optimization process traditionally focuses on the ultimate limit states (ULS). However, in the design of timber structures the performance of the structural members is often governed by the serviceability limit state (SLS) associated with different load levels than
Introduction: Occupational balance is the experience of having the right amount and right variation between work, domestic work, leisure, rest, and sleep. There is limited knowledge about which factors predict parents’ combined occupational balance, and if the combined occupational balance is associated with work and life satisfaction. Aim: The first aim was to explore whether domestic work and ch
A common assumption in product value literature is that authenticity is what contemporary consumers value the most. However, as this paper illustrates, the meaning of authenticity is unclear, and the term appears foreign to product development practitioners. The purpose of this paper is to explore in what ways product development professionals talk about product value in general and how this relat
The present research investigates the formative processes of international criminal law through the iterative citation of judicial decisions in adjudicatory practices. Given the centrality of the judge in the adjudication of international criminal law, this study is underpinned by a legal realist approach to international law informed by the work of Alf Ross (Scandinavian Legal Realism) and GregorThe present research investigates the formative processes of international criminal law through the iterative citation of judicial decisions in adjudicatory practices. Given the centrality of the judge in the adjudication of international criminal law, this study is underpinned by a legal realist approach to international law informed by the work of Alf Ross (Scandinavian Legal Realism) and Gregor
The production and consumption of fossil fuels need to decrease significantly to meet the 2015 Paris Agreement's ambitious climate change goals. However, fossil fuels continue to receive significant amounts of government support. Although reforming fossil fuel subsidies can yield climate change mitigation benefits, the specific international and domestic political context and political economy of
The international community has been engaged in capacity development for decades, sometimes under different names or with a slightly different focus. So far, these efforts have failed to bring significant and sustainable change. The Sendai Framework for Disaster Risk Reduction 2015–2030 specifies capacity development as the means to reduce disaster losses substantially. The purpose of this paper i
No drugs are currently approved that change the natural course of osteoarthritis (OA) and translate to long-term, clinically relevant benefits. Two-stage clinical trial designs for OA have now received FDA approval, but remaining challenges lie in defining suitable study populations, surrogate outcomes and pivotal long-term, clinically relevant trial endpoints.
We consider the Ginzburg–Landau functional, defined on a two-dimensional simply connected domain with smooth boundary, in the situation when the applied magnetic field is piecewise constant with a jump discontinuity along a smooth curve. In the regime of large Ginzburg–Landau parameter and strong magnetic field, we study the concentration of the minimizing configurations along this discontinuity b
The overall aim of this thesis is to gain a clearer picture of the differences in mobility among the young-old living in Sweden’s large metropolitan regions. This thesis comprises four papers. Paper I explores the inclusion of public transport as an element of mobility among the young-old living in the Stockholm region. Paper II presents an analysis of cycling among older people in the city of Mal
Användningen av plast kommer att fördubblas inom 20 år, enligt plastbranschen. Det handlar inte längre om att förbjuda sugrör eller plastkassar – det saknas en vision för hela plastanvändningen, skriver tre forskare i Lund
Bacteroides ovatus is a member of the human gut microbiota. The importance of this microbial consortium involves the degradation of complex dietary glycans mainly conferred by glycoside hydrolases. In this study we focus on one such catabolic glycoside hydrolase from B. ovatus. The enzyme, termed BoMan26A, is a β-mannanase that takes part in the hydrolytic degradation of galactomannans. The crysta
