Temporal pathway analysis of cerebrospinal fluid proteome in herpes simplex encephalitis
Objectives: We examined the temporal changes of the CSF proteome in patients with herpes simplex encephalitis (HSE) during the course of the disease, in relation to anti-N-methyl-D-aspartate receptor (NMDAR) serostatus, corticosteroid treatment, brain MRI and neurocognitive performance. Methods: Patients were retrospectively included from a previous prospective trial with a pre-specified CSF sampl