The function of astrocytes intertwines with the extracellular matrix, whose neuron and glial cell-derived components shape neuronal plasticity. Astrocyte abnormalities have been reported in the brain of the mouse model for fragile X syndrome (FXS), the most common cause of inherited intellectual disability, and a monogenic cause of autism spectrum disorder. We compared human FXS and control astroc

We consider dynamical systems (X, T, μ) which have exponential decay of correlations for either Hölder continuous functions or functions of bounded variation. Given a sequence of balls (Bn)n=1∞, we give sufficient conditions for the set of eventually always hitting points to be of full measure. This is the set of points x such that for all large enough m, there is a k< m with Tk(x) ∈ Bm. We also g

Brain injuries can interrupt descending neural pathways that convey motor commands from the cortex to spinal motoneurons. Here, we demonstrate that a unilateral injury of the hindlimb sensorimotor cortex of rats with completely transected thoracic spinal cord produces hindlimb postural asymmetry with contralateral flexion and asymmetric hindlimb withdrawal reflexes within 3 hr, as well as asymmetr

During and after the war in Croatia in the 1990’s, almost half of the 6000 partisan monuments erected between 1945 and 1990 were demolished. National sentiments ran high and these monuments were perceived as tokens of the regime that attacked Croatia in order to deny it independence. Most of these monuments were in places were fighting in the Second World War had taken place. In other regions, the

Accurate and efficient quantum control in the presence of constraints and decoherence is a requirement and a challenge in quantum information processing. Shortcuts to adiabaticity, originally proposed to speed up the slow adiabatic process, have nowadays become versatile toolboxes for preparing states or controlling the quantum dynamics. Unique shortcut designs are required for each quantum system

Aqueous sodium hydroxide solutions are extensively used as solvents for lignin in kraft pulping. These are also appealing systems for cellulose dissolution due to their inexpensiveness, ease to recycle and low toxicity. Cellulose dissolution occurs in a narrow concentration region and at low temperatures. Dissolution is often incomplete but additives, such as zinc oxide or urea, have been found to

Intrinsically disordered proteins (IDPs) are involved in many biological processes such as signalling, regulation and recognition. One of the main questions regarding IDPs is how sequence, structure and function are related. Phosphorylation, a type of post-translational modification prevalent in intrinsically disordered proteins and regions, is an example of how modifications at the sequence level

In this paper I argue against the traditional view that truth-making distributes over entailment and present a novel account that takes truth-making to distribute over grounding between the existence of facts, thus avoiding the shortcomings of the traditional view.In this paper I argue against the traditional view that truth-making distributes over entailment and present a novel account that takes truth-making to distribute over grounding between the existence of facts, thereby avoiding the shortcomings of the traditional view.

Shiga toxin (Stx), the unique virulence factor released by enterohemorrhagic Escherichia coli (EHEC), associated with gastrointestinal infection and in severe cases hemolytic uremic syndrome (HUS). Up until now, no effective therapies have been developed to control disease progression. In this thesis, four novel treatment strategies have been investigated targeting different aspects of EHEC pathog

Accelerated economic change in developing countries is rapidly transforming cities; existing urban systems and land-use patterns are poorly adapted to the scale of growth and the spatial restructuring of economic activity. Within this context, the paper assesses the challenges in educating planners in the knowledge and skills needed to deal with these trends. The paper argues for a review of plann

Structural adjustment (SA) — or macroeconomic reform — has become a dominant characteristic especially in developing countries, where national economies are being reshaped to a common discipline regardless of local circumstances. Within this context, the paper examines the impact of structural adjustment on disaster vulnerability in the urban sector, through examining some structural consideration

The interplay between international policies and the interests and internal pressures of the state is examined in the context of project‐based community participation in urban shelter provision in Egypt. Three contrasting upgrading projects are used. Using the concept of interest mediation, the paper argues that, whilst the state may be receptive to external pressure for community participation, t

Linking macro level political economy perspectives with micro level project-based analysis, the paper examines the impact of foreign technical assistance on urban sector projects in Egypt. The paper demonstrates how large aid flows into this sector, following Egypt's Western orientation after 1973, failed to achieve intended results. Three case studies, focusing on community development and partic

OBJECTIVE: The objectives of this study was to establish a sensitive and reproducible method to map the cartilage and subchondral bone proteomes in quantitative terms, and mine the proteomes for proteins of particular interest in the pathogenesis of osteoarthritis (OA). The horse was used as a model animal.DESIGN: Protein was extracted from articular cartilage and subchondral bone samples from thr

Hepatic failure is an important risk factor for poor outcome in septic patients. Using a chemical tagging workflow and high-resolution mass spectrometry, we demonstrate that rapid proteome remodeling of the vascular surfaces precedes hepatic damage in a murine model of Staphylococcus aureus sepsis. These early changes include vascular deposition of neutrophil-derived proteins, shedding of vascular