Fusidic acid (FA) is a steroid antibiotic commonly used against Gram positive bacterial infections. It inhibits protein synthesis by stalling elongation factor G (EF-G) on the ribosome after translocation. A significant number of the mutations conferring strong FA resistance have been mapped at the interfaces between domains G, III and V of EF-G. However, direct information on how such mutations a

The use of test coverage measures (e.g., block coverage) to control the software test process has become an increasingly common practice. This is justified by the assumption that higher test coverage helps achieve higher defect coverage and therefore improves software quality. In practice, data often shows that defect coverage and test coverage grow over time, as additional testing is performed. H

A method has been developed that automatically constructs a crystallographic refinement force field (topology and parameter files) for any molecule from a theoretical frequency calculation. The approach has been tested on five proteins containing metal sites or non-standard inhibitors or coenzymes and it is shown that the structures are improved in various aspects.

Popular Abstract in Swedish Recenta dödismiljöer framför Brúarjökull-glaciären på Island och Holmströmbreen på Svalbard har undersökts med speciellt fokus på landforms- och sedimentgenes samt kvantifiering av dödisavsmältningen. Fältmätningar, studier av tidsserier av flyg? och satellitbilder samt digitala terrängmodeller är dataunderlaget för kvantifieringen av dödisavsmältningen. SedimentologiskModern dead-ice environments in the glacier forefields of Brúarjökull, Iceland and Holmströmbreen, Svalbard were investigated with focus on landform and sediment genesis, as well as quantification of melting. Field monitoring and studies of multi-temporal aerial photographs, satellite imagery, and Digital Elevation Models (DEMs) provided data for the melting quantification. Sedimentological and ge

Background No data exist regarding mortality rate in young patients with a first-time anterior shoulder dislocation. A cohort of 255 patients aged 1240 years had a primary anterior shoulder dislocation during the years 1978 and 1979. After 10 years, 9 of the patients had died-which is a high figure for this cohort of patients. The question thus arose as to whether these patients had an increased m

This article investigates verb placement, especially verb second (V2), in post-puberty L2 learners of two closely related Germanic V2-languages, Swedish and German. Håkansson, Pienemann & Sayehli (2002) have adduced data from L1 Swedish-speaking learners of German in support of the claim that the syntactic property of V2 never transfers from the L1 to L2 interlanguage grammars. Regardless of L

Popular Abstract in Swedish Det svenska samhället har under senare delen av 1900-talet påverkats och förändrats på grund av en ökad internationell migration. År 1950 var 2,8 % av den svenska befolkningen utrikesfödd; idag utgör de utrikesfödda 12,0 % av totalbefolkningen. Om även andragenerationens migranter (de som har en eller båda föräldrar utrikesfödda) räknas med utgör första och andrageneratAims: The general aim of this thesis was to describe and compare the group of foreign-born persons living in Sweden and native Swedes with regard to health development over time, thus studying the influence of migration on health. Methods: All four studies are based on data from Statistics Sweden (SCB) and the National Board of Health and Welfare, Centre for Epidemiology covering the period 1970?

The purpose of this licentiate study is to analyze capillarity transport in building materials, and in order to do that, develop a new measurement method by which the moisture diffusivity at high moisture levels can be measured in an easy way.

Acetylenic bonds are present in more than 600 naturally occurring compounds. Plant enzymes that catalyze the formation of the Delta12 acetylenic bond in 9-octadecen-12-ynoic acid and the Delta12 epoxy group in 12,13-epoxy-9-octadecenoic acid were characterized, and two genes, similar in sequence, were cloned. When these complementary DNAs were expressed in Arabidopsis thaliana, the content of acet

Popular Abstract in Swedish Strävan efter förnyelse präglar det moderna samhället och dess organisationer. Överlevnad och framgång anses vara förknippad med förmågan att förändra och ompröva befintliga förhållanden. Det gäller snart sagt alla typer av verksamheter. Vi vet samtidigt att organisationer inte enbart utmärks av sin förmåga att ständigt förnyas. Etablerade arbetssätt, organiseringsformeThe aim of this thesis is to generate a theory of renewal in organizations. In modern society, characterized by the idea of progress, renewal has become an axiomatic assumption behind organizational existence. From an institutional perspective, the continuous search for new organizational forms and practises can be described as a process of imitation. The thesis acknowledges renewal as a process o

0 Context.-Plasma anti-Xa and anti-IIa activities correlate with the dose of low-molecular-weight heparin, and D-dimer and thrombin-antithrombin complexes are markers of procoagulant activity. Objective.-To investigate the relationship between plasma coagulation parameters and patient characteristics, including renal function, thromboprophylaxis, and incidence of venous thromboembolism (VTE) in th

Information on the effects of thyroid hormone on smooth muscle contractile protein expression and mechanical properties is sparse. We have addressed the following questions. (1) Can thyroxine hormone alter myosin isoform composition in smooth muscle? (2) Can a change in myosin isoform composition lead to altered mechanical properties in smooth muscle? (3) Are alterations, if occurring, equal in fa

The effect of random laser phase fluctuations on stimulated photon echoes (SPEs) and on coherently added SPEs was studied and evaluated both experimentally and analytically with statistical methods. The general concept of describing laser frequency fluctuations as a stationary stochastic process is presented and applied to three specific SPE configurations. The effect of phase fluctuations on eras

Absorption and fluorescence spectra of 2-R-5-phenyl-1,3,4-oxadiazoles (R = H, methyl, tert-butyl, trifluoromethyl, amino, phenyl, benzyl) were studied experimentally and by time dependent density functional theory (TDDFT) methods. In acidic media a substantial red shift is observed due to the presence of conjugate acid forms. Two conjugate acid forms (3H and 4H) are possible for unsymmetrically su

Abstract in German Die CEAP-Klassifizierung für chronische Venenleiden wurde 1994 durch ein internationales Ad-hoc-Komitee des American Venous Forum entwickelt, durch die Society for Vascular Surgery unterstützt und 1995 in die „Reporting Standards in Venous Disease“ inkorporiert. Inzwischen benutzen die meisten publizierten klinischen Arbeiten das CEAPSystem, ganz oder in Teilen. Um die KlassifizThe CEAP classification for chronic venous disorders (CVD) was developed in 1994 by an international ad hoc committee of the American Venous Forum, endorsed by the Society for Vascular Surgery, and incorporated into "Reporting Standards in Venous Disease" in 1995. Today most published clinical papers use all or portions of CEAP. Rather than have it stand as a static classification system, an ad ho